Recombinant Human Homeobox protein Hox-B13 (HOXB13)

1. These results indicate that risk alleles of HOXB13 and common variant SNPs are important components of inherited prostate cancer risk in the Norwegian population, although these factors appear to contribute little to the malignancy's aggressiveness. PMID: 29181843
2. Data show that homeo box B13 protein (HOXB13) single nucleotide polymorphisms (SNPs) missense mutations resulted in changed protein stability. PMID: 28272408
3. The expression of HOXB13, IL17BR, and mammaglobin 1 in sentinel lymph nodes predict the outcome of primary breast cancer patients. PMID: 29729704
4. These results identify HoxB13 as a pivotal upstream regulator of AR-V7-driven transcriptomes that are often cell context-dependent in CRPC, suggesting that HoxB13 may serve as a therapeutic target for AR-V7-driven prostate tumors. PMID: 29844167
5. This study evaluated the linkage evidence that identified recurrent mutation in HOXB13 as a risk factor for prostatic neoplasms. PMID: 28790484
6. this study revealed that HOXB9, HOXB13, and HOXD13 were upregulated and may play important roles in laryngeal squamous cell carcinoma (LSCC). Moreover, HOXB9 may serve as a novel marker of poor prognosis and a potential therapeutic target in LSCC patients. PMID: 28808656
7. none of the recurrent HOXB13 mutations that were identified in the Dutch population were associated with breast cancer risk, although it may be worthwhile to evaluate p.R217C in a larger study or a population with a higher allele frequency. PMID: 27424772
8. our results indicated that the G84E mutation in HOXB13 gene might increase susceptibility to prostate cancer PMID: 27626483
9. HOXB13 mutation is associated with prostate tumors. PMID: 28186998
10. CCAT1 regulates HOXB13 as a molecular decoy for miR-7, a microRNA that targets both CCAT1 and HOXB13, thus facilitating cell growth and migration in esophageal squamous cell carcinoma PMID: 27956498
11. This study presents in silico prediction approaches of the deleterious ns single nucleotide polymorphisms (missense) in the homeobox domain of human HOXB13 gene responsible for hereditary prostate cancer. PMID: 28072499
12. This is the first study to investigate the HOXB13 G84E mutation in Danish men. The mutation was detected in 0.49% of controls and in 2.51% of cases, and was associated with 5.12-fold increased relative risk of being diagnosed with prostate cancer. In our RP cohort, HOXB13 mutation carriers were more likely to develop aggressive prostate cancer. PMID: 26779768
13. HOXB13 is a useful marker for prostate origin when doubt exists regarding the site of the primary of a metastatic lesion PMID: 26931741
14. Tumor-associated macrophage-secreted CXCL8 downregulated the ERalpha expression of endometrial cancer cells via HOXB13, which may be associated with cancer invasion, metastasis and poor prognosis. PMID: 27018308
15. Study provides insights suggesting that HOXB13 plays an important role in prostate tumorigenesis and malignant progression via the regulation of both p21 and JNK signaling. PMID: 26781690
16. The Breast Cancer Index (BCI) is a continuous risk index model of two previously described biomarkers: molecular grade index (MGI) and HOXB13:IL17BR (H:I) ratio PMID: 26728744
17. Studies indicate that the germline homeo box B13 protein (HOXB13) p.Gly84Glu mutation is significantly increased the risk of cancers. PMID: 26517352
18. review the functions attributed to HOXB13, by highlighting the most recent findings supporting the hypothesis that HOXB13 might serve as a novel biomarker for the prognosis of prostate cancer PMID: 26709644
19. Recent studies have shown that HOXB13 is a strong candidate for familial Prostate cancer gene. PMID: 26841725
20. The strongest predictors are the BRCA2 mutations, and the highly penetrant G84E mutation in HOXB13 PMID: 26638190
21. We showed for the first time that HOXB13 is a sensitive and specific marker for detection of prostatic origin in distant metastases. PMID: 26590121
22. The associations between HOXB13 and prostate, leukemia, and bladder suggest that this gene is important in carcinogenesis. PMID: 26108461
23. Hoxb-13 overexpression is correlated with tumor angiogenesis, aberrant expression of EMT-associated markers and aggressive clinicopathological characteristics in pancreatic carcinoma. PMID: 26261579
24. The prevalence of somatic HOXB13 mutations in prostate cancer. PMID: 26176944
25. Our results show that HOXB13/SLUG and ALX4/SLUG axes are novel pathways that promote EMT and invasion of ovarian cancer cells. PMID: 25944620
26. our study highlights HOXB13 as strong and independent prognostic marker in prostate cancer PMID: 25825985
27. Data show that transcription factor FOXA1 and homeodomain protein HOXB13 colocalize with androgen receptor (AR) at tumor-specific AR binding sites. PMID: 26457646
28. HOXB13 G84E germline mutation is associated with prostate cancer risk. PMID: 25595936
29. Increased expression of HOXB13 protein is associated with HPV infection and cervical cancer progression. PMID: 25743797
30. P63 and HOXB13 is helpful in resolving the diagnosis. PMID: 26200506
31. We then show the value of this approach by using the imputed data to investigate the impact of the HOXB13 G84E mutation on age-specific prostate cancer risk and on risk of fourteen other cancers in the cohort PMID: 25629170
32. our results suggest that increased HOXB13 expression is associated with tumor angiogenesis and progression in hepatocellular carcinoma PMID: 25031711
33. High HOXB13 expression is associated with breast cancer. PMID: 23497539
34. The results suggest that the HOXB13-mediated promotion of tumor cell invasion is accomplished mainly through the downregulation of PDEF expression. PMID: 24898171
35. While the HOXB13 G84E mutation may be rare, there may be a future role in genetic testing for this mutation after further studies of clinical utility in assessing prostate cancer risk PMID: 24310616
36. identified common variants partially correlated with coding variant in the HOXB13 gene (G84E, rs138213197), which has been identified recently as a moderate penetrance prostate cancer susceptibility allele PMID: 24550738
37. HOXB13 promotes PCa invasion and metastasis by decreasing intracellular zinc levels, thus stimulating NF-kappaB signals, and acts as a modulator of intracellular zinc levels that promotes the malignant characteristics of PCa PMID: 24096478
38. HOXB13 contributes to G1/S and G2/M checkpoint controls in the prostate. PMID: 24325868
39. It might enhance cell injury caused by oxidative stress. PMID: 24213000
40. No HOXB13 mutation is associated with Ashkenazi Jewish men with prostate cancer. PMID: 23475555
41. HOXB13 G84E is prevalent in >1% of the Swedish population and is associated with a 3.5-fold increased risk of prostate cancer PMID: 22841674
42. findings suggest that novel molecular pathways may drive prostate cancer in HOXB13 G84E carriers PMID: 24722062
43. carriers of the rare G84E variant in HOXB13 were both younger at the time of diagnosis and more likely to have a family history of prostate cancer compared with homozygotes for the wild-type allele. PMID: 24148311
44. Our findings provide further evidences that the rare mutation in HOXB13 contributes to both hereditary and sporadic PCa risk. PMID: 24026887
45. A prostate cancer susceptibility allele at 6q22 increases RFX6 expression by modulating HOXB13 chromatin binding. PMID: 24390282
46. Letter/Meta-analysis: HOXB13 germline mutations in European men with prostate neoplasms. PMID: 23518396
47. This report is the first to suggest a risk of colorectal cancer associated with mutations in the HOXB13 gene PMID: 23541221
48. Our results demonstrate that HOXB13 expression identifies prostatic origin of a carcinoma PMID: 24146108
49. High HOXB13 mediates tamoxifen resistance and invasiveness in human breast cancer by suppressing ERalpha and inducing IL-6 expression. PMID: 23832664
50. HOXB13 mutation is associated with prostate cancer. PMID: 23396964

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HGNC: 5112

OMIM: 176807

KEGG: hsa:10481

STRING: 9606.ENSP00000290295

UniGene: Hs.66731