Recombinant Human Insulin receptor substrate 2(IRS2) ,partial

Code CSB-YP011830HU
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Source Yeast
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Code CSB-EP011830HU
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Source E.coli
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Code CSB-EP011830HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP011830HU
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Source Baculovirus
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Code CSB-MP011830HU
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names IRS2
Uniprot No. Q9Y4H2
Alternative Names Insulin receptor substrate 2; IRS 2; IRS-2; Irs2; IRS2_HUMAN
Species Homo sapiens (Human)
Protein Length Partial
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Data

Function May mediate the control of various cellular processes by insulin.
Gene References into Functions
  1. Study suggests that polymorphisms of IRS2 putatively participated in the development of pediatric MB development. PMID: 28303061
  2. Urinary sediment cell expression of IRS2 gene was significantly increased in the diabetic nephropathy (DN) patients compared with other groups. In patients with DN, urinary mRNA expression of the IRS2 gene is associated with kidney function. PMID: 29891743
  3. Insulin signaling pathway protects neuronal cell lines by Sirt3 mediated IRS2 activation. PMID: 29411439
  4. Acute loss of IRS1/IRS2 or inhibition of IR/IGF1R in KRAS-mutant human NSCLC cells decreases the uptake and lowers the intracellular levels of amino acids, while enhancing basal autophagy and sensitivity to autophagy and proteasome inhibitors. PMID: 29610318
  5. that MTNR1B and IRS2 gene variants impacted epicardial fat thickness, lipid profile and glucose homeostasis PMID: 28708046
  6. this meta-analysis indicates that IRS-2 gene rs1805097 polymorphism decreased the risk of CRC. PMID: 28212577
  7. IRS-1 and IRS-2 signaling interaction with the microtubule cytoskeleton and its response to AKT determines the response to microtubule disruption in breast carcinoma cells PMID: 28320862
  8. The study results were suggestive of a positive association between Gly972Arg of IRS1 and PCOS in the south Indian population, while INS, IRS2, PPAR-G and CAPN10 failed to show any association with PCOS in our studied population. PMID: 28360393
  9. We concluded that USP15 attenuates IGF-I signaling by antagonizing Nedd4-induced IRS-2 ubiquitination. PMID: 28126338
  10. these data highlight two novel regulatory proteins that could be therapeutically manipulated to limit IL-4-induced IRS-2 signaling and polarization of M2 macrophages in allergic inflammation. PMID: 27742835
  11. Proteasomal inhibition prolonged IRS-2 tyrosine phosphorylation, increased ubiquitination of IRS-2, and enhanced M2 gene expression. PMID: 27507812
  12. Findings suggest that insulin receptor substrate -1 Gly972Arg polymorphism is associated with polycystic ovary syndrome in the Caucasian ethnicity, and insulin receptor substrate -2 Gly1057Asp polymorphism is correlated with polycystic ovary syndrome in the Asian ethnicity. However, insulin receptor His 1058 C/T polymorphism may not be implicated in polycystic ovary syndrome. PMID: 27098445
  13. In the renal proximal tubule, insulin signaling via IRS1 is inhibited, while insulin signaling via IRS2 is preserved. Insulin signaling via IRS2 continues to stimulate sodium reabsorption in the proximal tubule and causes sodium retention, edema, and hypertension. PMID: 27247938
  14. miRNA-146a may function as a useful clinical tool in the treatment and diagnosis of ESCC, and its overexpression suppressed cell growth through inhibition of IRS2. PMID: 26508028
  15. High IRS2 expression is associated with myeloproliferative neoplasms. PMID: 26755644
  16. FSH decreases IRS-2 mRNA degradation indicating post-transcriptional stabilization. PMID: 26388164
  17. These data demonstrate for the first time that miR146a suppresses lung cancer progression by repressing IRS2 expression PMID: 26238771
  18. IRS-specific gene signatures represent accurate surrogates of IGF activity and could predict response to anti-IGF therapy in breast cancer. PMID: 26991655
  19. These results indicate that miR-106a* affects renal cell carcinoma (RCC) progression by targeting IRS-2 with suppression of the PI3K/Akt signaling pathway in RCC cells PMID: 26018509
  20. meta-analysis of genetic association studies: Data suggest that the D allele of the G1057D SNP in IRS2 has a significant effect on reducing risk of type 2 diabetes mellitus; obesity is a modifier of this association. [META-ANALYSIS, REVIEW] PMID: 25959789
  21. We conclude that AFB1 may upregulate IRS2 and stimulate lung cancer cell migration through Src PMID: 25820822
  22. IRS2 copy number gain, IGF-1R, IR-A, and IGFBP6 RNA expression levels, and KRAS and BRAF mutational status were identified as candidate predictive biomarkers for response to BMS-754807. PMID: 25527633
  23. Results suggest that a genetic variation in the insulin signaling pathway genes IRS1, IRS2 and INSR may affect the therapeutic response of temporal lobe epilepsy PMID: 25458098
  24. Study found significant association of the variant of IRS-2 gene as well as the interaction of IRS-1 and IRS-2 genes with polycystic ovary syndrome, especially in non-obese women from Taiwan. PMID: 25310961
  25. IRS2 phosphorylation is cell cycle-regulated and that Plk1 phosphorylation of IRS2 prevents premature mitotic exit via AKT inactivation. PMID: 25830382
  26. Changes in the expression levels of IRS1, IRS2, RIPK2, RSPO1, and DNA JC15 genes might contribute to the development of insulin resistance and glucose intolerance in the obese boys. PMID: 26040030
  27. Data (including data from knockout mice) suggest reduced insulin/IGF1 (insulin-like growth factor I) signaling slows progressive neurodegeneration of aging and increases life span via mechanism involving IRS2. [REVIEW] PMID: 25200290
  28. Increased expression of IRS2 is associated with oral squamous cell carcinoma. PMID: 24810113
  29. simulation shows that the wiring of the network determines different functions of IRS1 and IRS2. PMID: 24703981
  30. IGF-2, IGF-2R, and IRS-2 genes polymorphisms and their combinations are associated with risk of HCC PMID: 24656929
  31. IRS2 (rs2289046) GG genotype compared with AA+AG genotypes has a protective effect for colorectal cancer in normal weight subjects. PMID: 24175768
  32. The IRS2 rs1805097 polymorphism is not associated with colorectal and breast cancer risk. [Meta-analysis] PMID: 24497996
  33. Hepatitis C virus infection triggers endoplasmic reticulum stress and downregulates IRS1 and IRS2 through upregulation of SOCS-3. PMID: 25283858
  34. These results suggest that IRS-2 1057D allele may be associated with gestational diabetes mellitus. PMID: 24401133
  35. IRS1/2 promotes EMT and cell proliferation through stabilizing Dvl2. PMID: 24616100
  36. Differential regulation of IRS1 and IRS2 and of their downstream effectors AKT1 and AKT2 is consistent with upregulation of FOXO1 PMID: 23147115
  37. This study showed that three examined SNPs (rs2059806, Ala550Ala in INSR; rs1801123, Ala804Ala in IRS1; rs4773092, Cys816Cys, IRS2) did not show association with schizophrenia. PMID: 23706954
  38. Upregulation of IRS2 in the kidney tubules of diabetic nephropathy (DN) patients also indicates a novel role for IRS2 as a marker and/or mediator of human DN progression. PMID: 23617393
  39. IRS-2 Gly1057Asp polymorphisms are associated with T2DM in the Kurdish ethnic group. PMID: 22994406
  40. These data identify IRS2 as a likely driver oncogene in the prevalent 13q34 region of gain/amplification and suggest that IRS2 over-expression may provide an additional mechanism of PI3 kinase pathway activation in colorectal cancer. PMID: 23594372
  41. IRS-1 to IRS-2 ratios were lower in malignant than in benign prostatic tissue PMID: 23251408
  42. CaMK4 regulates beta-cell proliferation and apoptosis in a CREB-dependent manner and CaMK4-induced IRS-2 expression is important in these processes PMID: 23049845
  43. Amino acids 300-600 of IRS-2 are the 14-3-3 binding region with an important role for IGF-1/insulin-regulated phosphorylation of Ser-573. PMID: 22912850
  44. in elderly subjects the presence of the allelic variant Gly1057Asp of IRS2 gene was associated with the degree of insulin resistance and with epicardial fat thickness, suggesting its contribution to global cardiometabolic risk. PMID: 23018177
  45. Gly allele at codon 1057 in IRS-2 is correlated with an increased susceptibility to coronary artery disease in the Taiwanese population PMID: 23216712
  46. No significant associations were observed in IRS-2 Gly1057Asp polymorphism with polycystic ovary syndrome. PMID: 22523112
  47. CASP3 rs4862396, BMP5 rs3734444 and IRS2 rs7986346 may affect the survival in patients after androgen-deprivation therapy for prostate cancer PMID: 22844442
  48. no association between the IRS-1 and IRS-2 polymorphisms and Polycystic ovary syndrome were found. The results confirm that these polymorphisms should not be considered as major contributors to the pathogenesis of this disorder PMID: 22205343
  49. Defective IRS2 expression plays a role in the impaired hematopoietic cell differentiation in myelodysplastic syndrome. PMID: 22465474
  50. The rs2289046 polymorphism at the IRS2 gene locus may influence insulin sensitivity by interacting with certain plasma fatty acids in in metabolic syndrome subjects. PMID: 22147666

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Subcellular Location Cytoplasm, cytosol
Database Links

HGNC: 6126

OMIM: 600797

KEGG: hsa:8660

STRING: 9606.ENSP00000365016

UniGene: Hs.442344

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