Recombinant Human Integrin alpha-9(ITGA9) ,partial

Code CSB-YP619792HU
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Source Yeast
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Code CSB-EP619792HU
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Source E.coli
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Code CSB-EP619792HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP619792HU
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Source Baculovirus
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Code CSB-MP619792HU
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Source Mammalian cell
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Product Details

>85% (SDS-PAGE)
Target Names
Uniprot No.
Alternative Names
Alpha RLC; Integrin alpha 4 like ; Integrin alpha RLC; Integrin alpha-9; Integrin alpha-RLC; ITA9_HUMAN; ITGA 4L; ITGA 9; ITGA4L ; ITGA9; RLC
Homo sapiens (Human)
Protein Length
Tag Info
The following tags are available.
N-terminal His-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Please contact us to get it.

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Target Background

Integrin alpha-9/beta-1 (ITGA9:ITGB1) is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin.
Gene References into Functions
  1. ITGA9 expression was found to be increased in the suprabasal psoriatic epidermis. PMID: 28844950
  2. Our data suggest ITGA9, as a suppressor of HCC, prevents tumor cell migration and invasiveness through FAK/Src-Rac1/RhoA signaling. PMID: 29951557
  3. this study demonstrates the central role of alpha9 in pathogenic behaviors of rheumatoid arthritis fibroblast-like synoviocytes PMID: 29038247
  4. Metastatic prostate cancer cells cultured on osteo-mimetic surfaces coated with tenascin C exhibited enhanced adhesion and colony formation as mediated by integrin alpha9beta1. PMID: 28916657
  5. the expression levels of DLEC1 and ITGA9 were prominently decreased in lung tumor samples PMID: 27287342
  6. our results demonstrate that upregulation of ITGA9 in response to the decrease in miR-125b in metastatic melanoma is responsible for melanoma tumor cell migration and invasion. PMID: 26596831
  7. ITGA9 gene promoter is hypermethylated and downregulated in nasopharyngeal carcinoma. PMID: 26372814
  8. p75(NTR) and alpha9 integrin subunit are not closely associated through their cytoplasmic domains, most probably because of the molecular interference with other cytoplasmic proteins such as paxillin. PMID: 25748048
  9. alpha9beta1 integrin acts as a critical intrinsic regulator of human rheumatoid arthritis. PMID: 24241034
  10. rs189897 and rs2212020 genotypes of the ITGA9 are closely related to cerebral infarction, and the A-C haplotype is a protective factor against cerebral infarction. PMID: 21764681
  11. integrin alpha9beta1 is expressed in primary small cell lung cancer and patients having a high expression of alpha9beta1 demonstrated significantly worse long-term survival compared with patients with low alpha9beta1 expression PMID: 22370635
  12. Neuronal cadherin and alpha9-integrin are postulated as leading actors in the association between the Notch pathway and promotion of cell adhesion, motility and invasion in rhabdomyosarcoma cells PMID: 22976797
  13. expression of alpha9beta1 in breast cancer; alpha9beta1 acts as novel marker of basal-like breast cancer subtype; expression associated with reduced survival; its ability to promote cell migration and invasion suggests it contributes to aggressiveness of this subtype PMID: 21341269
  14. Differential capacity for VEGF-D production and integrin alpha 9 beta 1 expression by human breast cancer cell line MDA-MB-468LN jointly contributed to their lymphatic metastatic phenotype. PMID: 22545097
  15. Integrin alpha9 (ITGA9) expression and epigenetic silencing in human breast tumors PMID: 21975548
  16. endostatin reduces colorectal tumor-induced lymphangiogenesis, at least in part, by inhibiting EDA-integrin alpha9 pathway. PMID: 21465533
  17. the three-amino acid sequence, EYP, encoded by exon 3 of VEGF-A is essential for binding of VEGF to integrin alpha9beta1 and induces adhesion and migration of endothelial and cancer cells PMID: 21071450
  18. dysregulation of hMLH1, ITGA9, and RBSP3 associated multiple cellular pathways are needed for the development of early dysplastic lesions of the head and neck. PMID: 20412120
  19. up-regulation of alpha9beta1 expression among all beta1 integrins during neutrophil activation and transendothelial migration and a synergy between alpha9beta1 and beta2 integrins in stabilizing neutrophil adhesion to endothelium under flow conditions PMID: 20435742
  20. Data show that alpha9beta1 integrin engagement leads to the activation of integrin signaling pathways and potently reduces neutrophil spontaneous apoptosis, and that these effects are dependent on the activation of PI3K and MAPK pathways. PMID: 20362630
  21. Expression and activation of alpha9 integrin greatly enhances the ability of retinal pigment epithelial cells to adhere to wet age-related macular degeneration-affected Bruch's membranes. PMID: 20159768
  22. A genetic variation(s) in ITGA9 may influence susceptibility to nasopharyngeal carcinoma in the Malaysian Chinese population. PMID: 19478819
  23. although alpha9beta1 integrin can induce and localise to focal adhesions in a high activation state, its intermediate activity state normally supports cell adhesion consistent with migration. PMID: 19796635
  24. role in chemotaxis in conjuction with plasmin PMID: 15247268
  25. spermidine acetyltransferase directly binds to the alpha9 cytoplasmic domain and mediates alpha9-dependent enhancement of cell migration PMID: 15479742
  26. VEGF-C and VEGF-D are ligands for the integrin alpha9beta1 PMID: 15590642
  27. Data found that alpha9beta1 is a receptor for nerve growth factor and two other neurotrophins, and interaction of alpha9beta1 with NGF was confirmed in an ELISA assay by direct binding to purified integrin. PMID: 18230652
  28. tumor-cell expressions of alpha9 and beta1 integrins in combination with extracellular tenascin are necessary for medulloblastoma adhesion to the leptomeninges. PMID: 18794852
  29. Possible link between ITGA9 missens mutation and human fetuses with severe chylothorax. PMID: 18973153
  30. Down-regulation of RBSP3/CTDSPL, NPRL2/G21, RASSF1A, ITGA9, HYAL1 and HYAL2 genes in non-small cell lung cancer PMID: 19140316
  31. Polymerization of OPN generates a novel alpha9beta1-binding site and that the interaction of this site with the alpha9beta1 integrin is critical to the neutrophil chemotaxis induced by polymeric OPN. PMID: 19346516
  32. After forced expression of alpha9 integrin, extensive neurite outgrowth from PC12 cells and adult rat dorsal root ganglion neurons occurs. PMID: 19403822
  33. Inhibition of alpha(9) integrin function with an anti-alpha(9) integrin Ab significantly reduces the production of arthrogenic cytokines and chemokines and ameliorates ongoing arthritis PMID: 19494327
  34. The integrin alpha9beta1 is expressed on hematopoietic stem cells, and contributes to adhesion and differentiation of hematopoietic stem cells in the endosteal stem cell niche PMID: 19608669
  35. Results reveal an important role for integrin-alpha9 signaling during lymphatic valve morphogenesis and implicate it as a candidate gene for primary lymphedema caused by valve defects. PMID: 19686679

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Subcellular Location
Membrane; Single-pass type I membrane protein.
Protein Families
Integrin alpha chain family
Tissue Specificity
In airway epithelium, in the basal layer of squamous epithelium, and in smooth muscle, skeletal muscle, and hepatocytes. Abundantly expressed in fetal lung and lung cancers.
Database Links

HGNC: 6145

OMIM: 603963

KEGG: hsa:3680

STRING: 9606.ENSP00000264741

UniGene: Hs.113157

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