Recombinant Human Interleukin-24 (IL24)

1. Results show that iron-induced calcification in vascular smooth muscle cells occurred via IL-24; IL-24 was increased during the calcification process induced by iron, and IL-24 itself caused calcification in the absence of iron. These results confirmed the role of interleukin-24 as a candidate gene that might contribute to calcification in vascular media cells. PMID: 29330517
2. These results indicated that low expression of Mda-7/IL-24 along with high expression of C-myb are predictors for poor prognosis of Burkitt lymphoma patients; this outcome suggests that Mda-7/IL-24 and C-myb might be potential targets for clinical treatment of Burkitt lymphoma. PMID: 29415639
3. Secretome analysis revealed that Oct4 upregulated interleukin 24 (IL24) expression through STAT3 and NFkappaB signaling, and siRNA against IL24 increased IRinduced senescence, whereas recombinant human IL24 suppressed it. The results of the present study indicated that Oct4 confers IR resistance on breast cancer cells by suppressing IRinduced premature senescence through STAT3- and NFkappaB-mediated IL24 production. PMID: 29749438
4. These results suggest that hIL-24 can reverse the cisplatin (DDP)- resistance of lung cancer cells, and that the associated mechanism involves the induction of apoptosis and G2/M-phase arrest through the phosphoinositide3-kinase (PI3K)/AKT signaling pathway, as well as a decrease in drug resistance through P-gp expression PMID: 29048638
5. These results indicated that Mda7/IL24 could induce terminal differentiation of B lymphoma cells by regulating the expression of Blimp1 and Bcl6 via altering the P38 MAPK signaling pathway. PMID: 28849038
6. These results demonstrate a previously unrecognized role of IL24 in inhibition of translation, mediated through both phosphorylation of eIF2alpha and dephosphorylation of 4E-BP1, and provide the first direct evidence for translation control of gene-specific expression by IL24 PMID: 28461326
7. IL-24 inhibits AKT via regulating the HMGA1/miR-222 signaling node in human lung cancer cells and acts as an effective tumor suppressor. PMID: 27602961
8. this paper shows that IL-24 represents a potential biomarker of allergic inflammation and a Th2 polarized condition of the epithelium PMID: 26577568
9. Low IL24 expression is associated with endometriosis. PMID: 27624484
10. IL-20 and IL-24 increased the production of monocyte chemoattractant protein-1 by activated spondyloarthritis synovial fluid monocytes, decreased the production of Dickkopf-1 by SpA fibroblast-like synovial cells and induced mineralization in human osteoblasts; taken together, findings indicate disease-aggravating functions of IL-20 and IL-24 in spondyloarthritis PMID: 28369789
11. a novel pathway for mda-7/IL-24-induced caspase-independent apoptosis in neuroblastoma cells mediated through modulation of AIF, ATM, and gamma-H2AX. PMID: 27197168
12. mda-7/IL-24 directly regulates miRNA expression in cancer cells and highlights the novelty of the mda-7/IL-24-miR-221-beclin-1 loop in mediating cancer cell-specific death. PMID: 27940575
13. LINC00152-mediated oncogenic effects occur in part through the epigenetic silencing of IL24 expression following binding with EZH2. PMID: 28109288
14. mechanistic studies, inhibition of SRC and PKCdelta completely ablated the ability of MDA-7/IL-24 to reduce the Bcl-x(L)/(s) mRNA ratio and cell viability. These findings show that Bcl-x(s) expression is an important mediator of MDA-7/IL-24-induced cytotoxicity requiring the SRC/PKCdelta signaling axis in NSCLC cells. PMID: 27519412
15. Expression of IL-24 and IGFBP-3 significantly suppressed prostate cancer tumor growth in vivo. PMID: 26323436
16. Results suggest that IL-24 exerts a potent suppressive effect on influenza viral replication and can be used in the treatment of influenza infection. PMID: 27687232
17. Expression of IL-24 enhanced the sensitivity of B lymphoma cells to chemotherapy agents by altering the expression of multidrug-resistance genes via downregulating GTP-RhoA-ERK signaling pathway PMID: 26883473
18. IL20R1 correlated with prognosis of patients with pancreatic cancer, and mediates pancreatic cancer cell growth and migration. It may be a potential biomarker for IL24 molecular-targeted therapy. PMID: 26977011
19. The anti-viral effect of IL-24 correlated with caspase-3 activation and could be blocked by a pan-caspase inhibitor and by small interfering RNA (siRNA) directed towards TLR3. PMID: 26367324
20. This study demonstrated that IL-19 and IL-24 are associated with the modulation of T-cell responses in filarial infections. PMID: 26486636
21. This study indicates that IL-24 upregulates expression and activation of double-stranded RNA-activated protein kinase, further increasing expression and activation of eIF-2alpha, and decreasing Bcl-2 to promote apoptosis. PMID: 26168134
22. The association of IL-24 polymorphisms with metabolic and cardiovascular risk factors. PMID: 24552169
23. Data show that Adenovirus-mediated interleukin 24 (Ad-IL-24) gene therapy suppresses growth of lung carcinoma cells SPC-A1 both in vitro and in vivo. PMID: 25479732
24. gene transfer to drive IL24 expression in chronic myeloid leukemia cell lines resulted in cytotoxicity specifically to cancer cells. PMID: 26097559
25. IL-24 may enhance tumor chemosensitivity to cisplatin. PMID: 25778843
26. MDA-7/IL-24 inhibits Nrf2-mediated antioxidant response through activation of p38 pathway and inhibition of ERK pathway involved in cancer cell apoptosis. PMID: 25236495
27. High expression of IL-24 was significantly correlated with second primary malignancy indicator in head and neck squamous cell carcinoma. PMID: 25091574
28. Distribution of interleukin-10 family cytokines in serum and synovial fluid of patients with inflammatory arthritis reveals different PMID: 25178435
29. IL-24 has a role in sensitizing melanoma cells to erlotinib through modulation of the Apaf-1 and Akt signaling pathways PMID: 20216471
30. The results suggest that IL-24 can induce neuroblastoma cell differentiation and apoptosis and may be a potential therapeutic agent for neuroblastoma. PMID: 23692552
31. MDA-7/IL-24: multifunctional cancer killing cytokine. PMID: 25001534
32. elevated gene expression in Mexican mestizo patients with active Crohn's disease PMID: 24527982
33. These results suggest a possible contribution of IL-24 to squamous cell carcinoma invasion via enhancing focal expression of MMP7. PMID: 24270662
34. We found that IL-24 effectively inhibits SH-SY5Y neuroblastoma cell migration and invasion by changing subcellular localization and cellular levels of beta-catenin and regulating the levels of proteins associated with cell migration and invasion PMID: 24084981
35. a novel MDA-7/IL-24-GAS3-beta1integrin-fibronectin signaling pathway that suppresses breast cancer growth, is reported. PMID: 23468528
36. this study indicates that overexpression of IL-24 gene can significantly promote chemosensitivity in MDR phenotype SGC7901/CDDP gastric cancer cells. PMID: 23982423
37. MDA-7/IL-24 has a role in cancer-specific apoptosis through SARI induction PMID: 24282278
38. mediates T cell microvesicles-induced mast cell activation; contributes to T cell-mediated skin inflammation PMID: 23768573
39. MDA-7/IL-24 overexpression decreased the expression of CD44. PMID: 23722307
40. IL-24 was strongly expressed in human psoriatic epidermis. Pharmacological inhibition of NF-kappaB increased IL-24 expression in TNF-stimulated human primary keratinocytes. PMID: 24211183
41. The role of mda-7/IL-24 is inhibits decreasing of adhesion and invasion in vitro, blocking cell cycle, down-regulating the expression of ICAM-1, MMP-2/9, CDK1, the phosphorylation of ERK and Akt, NF-kappaB and AP-1 transcription activity. PMID: 23772146
42. Our findings demonstrate that MDA-7/IL-24 is be a safe and effective way to eradicate cancers and also potentially establish disease-free survival PMID: 23720015
43. This suggests that IL-24 plays a profound role in suppressing tumour lymphangiogenesis, thereby, reducing the likelihood of cancer metastasis via the lymphatic route. PMID: 23546515
44. results demonstrate that the inflammatory cytokines TNFalpha and IL24 are direct targets of miR-203 in keratinocytes PMID: 22917968
45. Data suggest that IL24 is ubiquitinated and degraded by 26S proteasomes; data from site-directed mutagenesis study suggest that lysine 123 is the major internal lysine involved in ubiquitination of IL24; K123R mutant promotes apoptosis of HeLa cells. PMID: 23078624
46. IL-24 appears to promote wound chronicity via its inhibitory effect on the migratory behavior of human keratinocytes, mediated through an AKT-dependent pathway. PMID: 23110359
47. this study may provide a novel mechanism of action of IL-24 in cardiovascular disease and indicates that IL-24 is a potential therapeutic agent in VSMC calcification. PMID: 23063979
48. IL-24 produced by maternal-fetal interface in human first trimester pregnancy may influence the invasion of trophoblasts and is involved in normal pregnancy. PMID: 18704311
49. IL-24 could activate human CD8(+) T cells, driving CD8(+) T cells to produce interferon-gamma (IFN-gamma) and counteract tuberculosis. PMID: 21787878
50. Transduction of murine tumors with adenoviruses expressing the human IL-24 gene however suppressed the viability and decreased the tumor growth PMID: 22475191

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HGNC: 11346

OMIM: 604136

KEGG: hsa:11009

STRING: 9606.ENSP00000375795

UniGene: Hs.58831