Recombinant Human Membrane-associated phosphatidylinositol transfer protein 3(PITPNM3),partial

In Stock
Code CSB-EP863164HU
Size US$306
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Product Details

Greater than 90% as determined by SDS-PAGE.
Target Names
Uniprot No.
Research Area
Alternative Names
CORD5; Membrane associated phosphatidylinositol transfer protein 3; membrane-associated 3; Membrane-associated phosphatidylinositol transfer protein 3; MGC157740; MGC157741; NIR 1; NIR-1; NIR1; Phosphatidylinositol transfer protein; Phosphatidylinositol transfer protein, membrane-associated 3; PITM3_HUMAN; PITPnm 3; PITPNM; PITPNM family member 3; Pitpnm3; PYK2 N terminal domain interacting receptor 1; Pyk2 N-terminal domain-interacting receptor 1; RDGBA3; Retinal degeneration B alpha 3
Homo sapiens (Human)
Expression Region
Target Protein Sequence
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
Mol. Weight
30.8 kDa
Protein Length
Tag Info
N-terminal 10xHis-tagged and C-terminal Myc-tagged
Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Tris-based buffer,50% glycerol
and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
3-7 business days
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA
Please contact us to get it.

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Target Background

Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro). Binds calcium ions.
Gene References into Functions
  1. CCL18 can increase the invasive ability of non-small cell lung cancer cells by binding to its receptor Nir1. PMID: 26756176
  2. CCL18 enhances hepatocellular carcinoma (HCC) cell migration, invasion, and epithelial-mesenchymal transition (EMT) through the expression of PITPNM3 and the activation of the NF-kappaB signaling pathway. PMID: 26449829
  3. Data indicate that PYK2 N-terminal domain interacting receptor 1 (Nir1) could induce epithelial-mesenchymal transition by stabilising Snail via the PI3K/Akt/GSK3beta/Snail signalling pathway through binding to CCL18. PMID: 24001613
  4. Our observations of the PITPNM3 p.Q626H mutation carriers confirm that CORD5 is a disease not to mix with other retinal degenerations mapped to 17p13. PMID: 22405330
  5. CCL18 derived from Tumor-associated macrophages (TAMs) lays a critical role in promoting breast cancer metastasis via its receptor, PITPNM3. PMID: 21481794
  6. Thus, mutations in PITPNM3 do not appear to be a major cause of cone or cone-rod dystrophy. PMID: 20590364
  7. Our finding on the first mutation in the human homologue of Drosophila rdgB indicates novel pathways and a potential important role of the PITPNM3 in mammalian phototransduction. PMID: 17377520
  8. Mutation in the PYK2-binding domain of PITPNM3 causes autosomal dominant cone dystrophy (CORD5) in two Swedish families. PMID: 18188949

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Involvement in disease
Cone-rod dystrophy 5 (CORD5)
Subcellular Location
Endomembrane system; Peripheral membrane protein.
Protein Families
PtdIns transfer protein family, PI transfer class IIA subfamily
Tissue Specificity
Detected in brain and spleen, and at low levels in ovary.
Database Links

HGNC: 21043

OMIM: 600977

KEGG: hsa:83394

STRING: 9606.ENSP00000262483

UniGene: Hs.183983

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