Recombinant Human Plakophilin-1 (PKP1)

1. These results implicate the participation of PKP1 in early tooth morphogenesis as an effector of canonical Wnt signaling that controls ameloblast differentiation via regulation of the cell adhesion complex PMID: 27015268
2. Collectively, altered expression of PKP1 and SPOCK1 appears to be a frequent and critical event in prostate cancer PMID: 26138584
3. cytoplasmic PKP1/3 are components of mRNA ribonucleoprotein particles and act as posttranscriptional regulators of gene expression. PMID: 25225333
4. Plakophilin-1 has a role in protecting keratinocytes from pemphigus vulgaris IgG by forming calcium-independent desmosomes PMID: 24056861
5. Data indicate that upon activation of growth factor signaling, plakophilin 1 switches from a desmosome-associated growth-inhibiting to a cytoplasmic proliferation-promoting function. PMID: 23444369
6. In breast cancer, compared with normal tissue, PKP1 and PKP2 expressions were indifferent (P > 0.05), but PKP3 expression was significantly increased PMID: 21947748
7. PKP1 loss secondary to promoter methylation, as well as other mechanisms, may promote the progression of Barrett's esophagus to esophageal adenocarcinoma in a subset of patients via decreased desmosome assembly and increased cell motility PMID: 22170739
8. both loss of PKP1 and up-regulation of PKP3 expression are biologically important events in prostate cancer and are associated with a more aggressive phenotype PMID: 20348237
9. in addition to mediating desmosome assembly, the nuclear pool of Pkp can influence cell survival by interactions with DNA PMID: 20613778
10. These findings identify PKP1 as a regulator of translation and proliferation via modulation of eIF4A1 activity. PMID: 20156963
11. the clinicopathologic features attest to the significant role of PKP1 in stabilization of desmosome structure and function, predominantly in the spinous layers of the epidermis PMID: 19945625
12. Genotype-phenotype correlation in skin fragility-ectodermal dysplasia syndrome resulting from mutations in plakophilin 1. Homozygous intron 11 donor splice site mutation in the plakophilin 1 gene, 2021+1 G>A. PMID: 11994137
13. The PKP1 null patients showed poorly developed inner and outer desmosomal plaques and reductions in the lower suprabasal layer desmosome size and number so pkp1 has a recruiting and stabilizing role in desmosome formation PMID: 12839569
14. plakophilin 1 has a key role in increasing desmosomal protein content, in desmosome assembly, and in regulating cell migration PMID: 12840072
15. crystal structure of the arm repeat domain from plakophilin-1 (PKP1), a member of the p120ctn subfamily that is found in desmosomes PMID: 15663951
16. Co-expression of a classical cadherin (N-cadherin) and plakophilin-1/ER in A431D cells resulted in punctate desmoplakin staining at cell-cell borders PMID: 15988759
17. Compound heterozygosity for new splice site mutations in the plakophilin 1 gene (PKP1) in a Chinese case of ectodermal dysplasia-skin fragility syndrome PMID: 16159729
18. the Plakophilin-1 carboxyl terminus recruits it to plasma membrane, whereas amino terminus recruits desmoplakin and promotes desmosome assembly PMID: 16632867
19. The Ki67+ proliferation index was inversely correlated with desmoplakin and plakophilin-1 during cervical squamous cell carcinogenesis PMID: 17593084
20. Loss of plakophilin-1 expression during head and neck squamous cell carcinoma (HNSCC) progression may contribute to an invasive phenotype. PMID: 17668353
21. a homozygous nonsense mutation, p.R672X, in the PKP1 gene is similar to the molecular pathology underlying other cases of ectodermal dysplasia-skin fragility syndrome PMID: 19016709

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HGNC: 9023

OMIM: 601975

KEGG: hsa:5317

STRING: 9606.ENSP00000263946

UniGene: Hs.497350