Recombinant Human Pleckstrin homology domain-containing family N member 1 (PLEKHN1)

Code CSB-YP672075HU
MSDS
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Source Yeast
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Code CSB-EP672075HU
MSDS
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Source E.coli
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Code CSB-EP672075HU-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP672075HU
MSDS
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Source Baculovirus
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Code CSB-MP672075HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
PLEKHN1
Uniprot No.
Alternative Names
PLEKHN1; CLPABP; Pleckstrin homology domain-containing family N member 1; PH domain-containing family N member 1; Cardiolipin and phosphatidic acid-binding protein
Species
Homo sapiens (Human)
Expression Region
1-663
Target Protein Sequence
MGNSHCVPQA PRRLRASFSR KPSLKGNRED SARMSAGLPG PEAARSGDAA ANKLFHYIPG TDILDLENQR ENLEQPFLSV FKKGRRRVPV RNLGKVVHYA KVQLRFQHSQ DVSDCYLELF PAHLYFQAHG SEGLTFQGLL PLTELSVCPL EGSREHAFQI TGVWDASRAP RGTPDPGLGE GPALWLRSTC VYVCALSALP AGPLPAPLLV LCPSRAELDR WLYHLEKQTA LLGGPRRCHS APPQGSCGDE LPWTLQRRLT RLRTASGHEP GGSAVCASRV KLQHLPAQEQ WDRLLVLYPT SLAIFSEELD GLCFKGELPL RAVHINLEEK EKQIRSFLIE GPLINTIRVV CASYEDYGHW LLCLRAVTHR EGAPPLPGAE SFPGSQVMGS GRGSLSSGGQ TSWDSGCLAP PSTRTSHSLP ESSVPSTVGC SSQHTPDQAN SDRASIGRRR TELRRSGSSR SPGSKARAEG RGPVTPLHLD LTQLHRLSLE SSPDAPDHTS ETSHSPLYAD PYTPPATSHR RVTDVRGLEE FLSAMQSARG PTPSSPLPSV PVSVPASDPR SCSSGPAGPY LLSKKGALQS RAAQRHRGSA KDGGPQPPDA PQLVSSAREG SPEPWLPLTD GRSPRRSRDP GYDHLWDETL SSSHQKCPQL GGPEASGGLV QWI
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Controls the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3' UTR, in cooperation with the RNA stabilizer ELAVL1. Decreases the stability of the leptin mRNA by antagonizing the function of ELAVL1 by inducing its atypical recruitment from the nucleus to the cytosol. Binds to cardiolipin (CL), phosphatidic acid (PA), phosphatidylinositol 4-phosphate (PtdIns(4)P) and phosphatidylserine (PS). Promotes apoptosis by enhancing BAX-BAK hetero-oligomerization via interaction with BID in colon cancer cells.
Subcellular Location
Cell membrane; Lipid-anchor. Mitochondrion. Mitochondrion membrane.
Tissue Specificity
Ubiquitous. Epressed in several cancer cell lines of differing origin.
Database Links

HGNC: 25284

KEGG: hsa:84069

UniGene: Hs.528691

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