Recombinant Human Presenilins-associated rhomboid-like protein, mitochondrial(PARL),partial

Code CSB-YP880960HU1
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Source Yeast
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Code CSB-EP880960HU1
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Source E.coli
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Code CSB-EP880960HU1-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP880960HU1
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Source Baculovirus
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Code CSB-MP880960HU1
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names PARL
Uniprot No. Q9H300
Alternative Names Mitochondrial intramembrane cleaving protease PARL; Mitochondrial intramembrane-cleaving protease PARL ; P-beta; parl; PARL_HUMAN; Pbeta; presenilin associated rhomboid-like ; Presenilins associated rhomboid-like protein; PRO2207; PSARL; PSARL1; PSENIP2; RHBDS1; Rhomboid 7 homolog 1
Species Homo sapiens (Human)
Protein Length full length protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

Target Data

Function Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptoptic signals (By similarity). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain.
Gene References into Functions
  1. PARL preserves mitochondrial membrane homeostasis via STARD7 processing and is emerging as a critical regulator of protein localization between mitochondria and the cytosol PMID: 29301859
  2. Study confirmed that common variants in PARL and PINK1 were associated with leprosy. Furthermore, PARL and PINK1 could physically interact with each other and were involved in the highly connected network formed by reported leprosy susceptibility genes. PMID: 27876828
  3. PDK2/PARL senses defects in mitochondrial bioenergetics. PMID: 28178523
  4. Adipogenic process can be dissected into 3 stages according to the participation of PARL-PINK1-Parkin system. Findings reveal the sequential adipogenic events directed by PARL-PINK1-Parkin system, add more evidence supporting the convergence of pathogenesis leading to neurodegenerative and metabolic disease PMID: 28641777
  5. These findings enrich the allelic spectrum of ABCC5 in PACG. We identified no tagging SNP responsible for the association of the whole region. PMID: 28813580
  6. These results reveal a pro-apoptotic function of PARL and identify PARL-mediated Smac processing and cytochrome c release facilitated by OPA1-dependent cristae remodelling as two independent pro-apoptotic pathways in mitochondria. PMID: 28288130
  7. Its mutations are a rare cause of PD and genetic variants are neither strong nor common risk factors in Parkinson disease. PMID: 26778534
  8. pathogenic PINK1 mutants which are not cleaved by PARL affect PINK1 kinase activity and the ability to induce PARK2-mediated mitophagy. PMID: 26101826
  9. Common genetic variants of the PINK1 and PARL genes are unlikely to be involved in schizophrenia. PMID: 25354644
  10. the frequency of the haplotype AAC, and AAT were significantly higher in the unaffected cases and the frequencies of haplotype GGT were significantly higher in LHON cases PMID: 23973714
  11. Rhomboid protease PARL mediates the mitochondrial membrane potential loss-induced cleavage of PGAM5. PMID: 22915595
  12. p.S77N variant, and, possibly, mutations in the PARL protein overall, are not a frequent cause of autosomal recessive early-onset Parkinson's disease PMID: 21953724
  13. work provides unexpected insights into the structural determinants regulating Parl stability and activity in vivo, and reveals a complex cascade of proteolytic events controlling the function of the protease in the mitochondrion PMID: 21415861
  14. PARL deficiency impairs PARKIN recruitment to mitochondria. PMID: 21355049
  15. the PARL-catalyzed removal of the Pink1 signal sequence in the canonical import pathway acts as a cellular checkpoint for mitochondrial integrity PMID: 21426348
  16. Mitochondrial protease PARL cleaves PINK1 at position A103. PMID: 21138942
  17. Data show that no association between PARL gene SNPs and LHON in Chinese patients with m.11778G>A. PMID: 20711738
  18. variants of PARL are suggested to influence cell death by apoptosis which has long been believed to intrigue the neurodegeneration of LHON. PMID: 20407791
  19. Results suggest that genetic variation within PARL influences mitochondrial abundance and integrity. PMID: 19862556
  20. results indicate a different function and mechanism of Hax1 in apoptosis and re-opens the question of whether mammalian PARL, in addition to apoptosis, regulates mitochondrial stress response through Omi/HtrA2 processing. PMID: 19680265
  21. PARL might mediate a developmentally regulated mitochondria-to-nuclei signaling through regulated proteolysis of its N terminus and release of the Pbeta peptide PMID: 14732705
  22. Variation in PSARL sequence and/or expression may be an important new risk factor for type 2 diabetes and other components of the metabolic syndrome. PMID: 15729572
  23. The Leu262Val variant is unlikely to be an important contributor to insulin resistance. PMID: 17019603
  24. the PARL rs3732581 genetic variant may have a role in insulin levels, metabolic syndrome and coronary artery disease PMID: 18758826
  25. Genetic variation of PARL may indicate earlier onset of type 2 diabetes and increased susceptibility to nephropathy and cardiovascular complications. PMID: 19185381

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Subcellular Location Mitochondrion inner membrane, Multi-pass membrane protein, SUBCELLULAR LOCATION: P-beta: Nucleus
Protein Families Peptidase S54 family
Database Links

HGNC: 18253

OMIM: 607858

KEGG: hsa:55486

STRING: 9606.ENSP00000325421

UniGene: Hs.478469

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