Recombinant Human Presenilins-associated rhomboid-like protein, mitochondrial(PARL)

Code CSB-CF880960HU
Product Type Transmembrane Protein
Size Pls inquiry other sizes
Uniprot No. Q9H300
Storage Buffer Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Species Homo sapiens (Human)
Source in vitro E.coli expression system
Gene Names PARL
Protein Names Recommended name: Presenilins-associated rhomboid-like protein, mitochondrial EC= Alternative name(s): Mitochondrial intramembrane cleaving protease PARL Cleaved into the following chain: 1. P-beta Short name= 2. Pbeta
Expression Region 53-379
Tag Info N-terminal 10xHis-tagged
Protein Description Full Length of Mature Protein
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptoptic signals (By similarity). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain.
Subcellular Location Mitochondrion inner membrane, Multi-pass membrane protein, SUBCELLULAR LOCATION: P-beta: Nucleus
Protein Families Peptidase S54 family
Database Links

HGNC: 18253

OMIM: 607858

KEGG: hsa:55486

STRING: 9606.ENSP00000325421

UniGene: Hs.478469

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