Greater than 90% as determined by SDS-PAGE.
Protein phosphatase 2C isoform alpha; EC 184.108.40.206; FLJ42306; IA; MGC9201; Mpp alpha ; PP2C alpha; PP2C-alpha; PP2CA; PP2Calpha; PPM 1A; PPM1A; PPM1A_HUMAN; PPPM1A; Protein phosphatase 1A (formerly 2C) magnesium dependent alpha isoform; Protein phosphatase 1A; Protein phosphatase 1A magnesium dependent alpha ; Protein phosphatase 2C alpha; Protein phosphatase 2C alpha isoform; Protein phosphatase 2C isoform alpha; Protein phosphatase IA; Protein phosphatase, Mg2+/Mn2+ dependent, 1A
Homo sapiens (Human)
Target Protein Sequence
Note: The complete sequence including tag
sequence, target protein sequence and linker sequence could be provided upon request.
Liquid or Lyophilized powder
Note: We will preferentially ship the format that
we have in stock, however, if you have any special requirement for the format, please remark your
requirement when placing the order, we will prepare according to your demand.
If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the
glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer,
6% Trehalose, pH 8.0.
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature
and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized
form is 12 months at -20°C/-80°C.
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA
Please contact us to get it.
This Human PPM1A recombinant protein was produced in E.coli, where the gene sequence encoding Human PPM1A (1-382aa) was expressed with the N-terminal GST tag. The purity of this PPM1A protein was greater than 90% by SDS-PAGE.
PPM1A is a serine/threonine protein phosphatase, and its primary function is to remove phosphate groups from proteins, thereby regulating the activity of cellular signaling pathways. It participates in several critical biological processes by dephosphorylating proteins, including cell growth, cell differentiation, apoptosis, and cell cycle control.
PPM1A plays a role in regulating various signaling pathways. For example, it can modulate the Protein Kinase B (PKB or Akt) signaling pathway, which is important for cell survival and proliferation. Additionally, PPM1A can regulate the Nuclear Factor-κB (NF-κB) signaling pathway, which is involved in immune responses and inflammation.
Abnormal expression or mutations in PPM1A may be associated with the development of various diseases. For instance, some studies have suggested that abnormal expression of PPM1A is linked to the onset and growth of tumors, implying its potential role in the pathogenesis of cancer. Furthermore, PPM1A may also be associated with neurological disorders, cardiovascular diseases, and several other conditions.