Recombinant Human Proton-coupled amino acid transporter 1 (SLC36A1), partial

1. A mechanism through which amino acids may suppress the expression of PAT1 on lysosomes by inducing protein cleavage to remove a targeting signal. PMID: 28670736
2. Data indicate that the glycosylation-deficient mutant of amino acid transporter PAT1 (PAT1(3)(NQ) ) is unstable and is degraded mainly via the endoplasmic reticulum-associated degradation pathway in HEK293 cells. PMID: 28117901
3. Sertraline is an apparent non-competitive inhibitor of PAT1-mediated transport. PMID: 23962042
4. Data suggest that PAT1 in enterocytes is responsible for intestinal absorption of some of the alkaloids from areca nut (i.e., arecaidine, guvacine, isoguvacine). PMID: 23488788
5. estrogen attenuates the activity of PAT1 by directly closing PAT1 PMID: 22975709
6. In hPAT1 expressing oocytes Gly-Tyr, Gly-Pro, and Gly-Phe inhibited currents induced by drug substances. PMID: 22853447
7. PATs function as part of an amino acid-sensing engine that drives mTORC1 activation from endosomal and lysosomal membranes PMID: 22574197
8. In human cells, SLC36A1 localized on intracellular membranes is required for amino acid-dependent mTORC1 activation and cell proliferation. SLC36A1 also has similar in vivo growth regulatory activity to fly SLC36 AAAPs when expressed in Drosophila. PMID: 20498635
9. PAT1 expressed exclusively in apical membrane of Caco-2 cells. hPAT1 may be responsible for H(+)-coupled amino acid transport expressed in apical membrane of Caco-2 cells. PMID: 12527723
10. A high-capacity imino acid carrier localized at the small intestinal luminal membrane that transports nutrients and amino acids and imino acids. PMID: 15521011
11. Amino acid uptake via hPAT1 is inhibited by activators of the cAMP pathway indirectly through inhibition of NHE3 activity. PMID: 15754324
12. PAT1a, which is 99.0% identical to protein interacting with APP tail 1 (PAT1), is a functional link between the transport and processing of beta-amyloid precursor protein APP and its two paralogs APLP1 and APLP2 in vivo. PMID: 17050537
13. His-55 might be responsible for binding and translocation of H+ in the course of cellular amino acid uptake by PAT1. PMID: 18230330
14. This study is the first to demonstrate both taurine uptake via PAT1 and functional expression of PAT1 at the apical membrane of the intestinal epithelium. PMID: 19074966
15. Data conclude that hPAT1 might be responsible for the intestinal absorption of beta-GPA thereby allowing its oral administration. PMID: 19358571
16. The role of N-glycosylation in transport function and surface targeting of the human solute carrier PAT1 PMID: 19409386
17. a disulfide bridge is essential for the transport function of the human proton-coupled amino acid transporter hPAT1 PMID: 19549785

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HGNC: 18761

OMIM: 606561

KEGG: hsa:206358

STRING: 9606.ENSP00000243389

UniGene: Hs.269004