Recombinant Human Serine/threonine-protein kinase haspin (GSG2)

1. The mitotic histone kinase Haspin binds to the cohesin regulatory subunit Pds5B through a conserved YGA/R motif in its non-catalytic N terminus, which is similar to the recently reported YSR-motif-dependent binding of Wapl to Pds5B. PMID: 28343965
2. The authors' data identify the HIM of Pds5 as a binding motif for Haspin/Hrk1 in fission yeast. The authors' analyses also show that human PDS5B binds Haspin through the same HIM-PIM interaction module, indicating that the Haspin localization mechanism is highly conserved. PMID: 28343969
3. Autosomal recessive RP associated with mutations in the male germ cell-associated kinase (MAK) gene is associated with preservation of foveal vision even in advanced stages of retinal degeneration despite similar rates of peripheral visual field loss to other forms of autosomal recessive RP PMID: 29103961
4. This is the first structural model of a bisubstrate inhibitor targeting haspin. The presented structural data represent a model for the future development of more specific haspin inhibitors PMID: 27139824
5. Haspin kinase plays a key role in maintaining the slowly exchanging centromere Borealin pool. PMID: 25854549
6. Haspin activity affects the phosphorylation state of proteins involved in gene expression regulation and splicing. PMID: 24732914
7. Haspin inhibitors reveal centromeric roles of Aurora B in chromosome movement and spindle checkpoint signaling PMID: 23071152
8. Aurora B phosphorylates Haspin to promote generation of H3T3ph and that Aurora B kinase activity is required for normal chromosomal localization of the CPC, indicating an intimate linkage between Aurora B and Haspin functions in mitosis PMID: 21658950
9. findings show phosphorylation of histone H3-threonine 3 mediated by Haspin cooperates with Bub1-mediated histone 2A-serine 121 phosphorylation in targeting the chromosomal passenger complex to the inner centromere in fission yeast and human cells PMID: 20929775
10. phosphorylation of H3T3 by Haspin is necessary for chromosomal passenger complex(CPC) accumulation at centromeres; Survivin binds to H3T3ph; H3T3ph generated by Haspin positions CPC at centromeres to regulate selected targets of Aurora B during mitosis PMID: 20705812
11. Haspin-depleted cells reveal that spindle-pole integrity in mitosis requires chromosome cohesion. PMID: 19910498
12. Haspin is a relatively newly discovered kinase that phosphorylates histone H3 during mitosis and appears to play a role in regulating chromosome behavior during cell division. [REVIEW] PMID: 19997740
13. This work reveals a new kinase involved in composing the histone code and adds haspin to the select group of kinases that integrate regulation of chromosome and spindle function during mitosis and meiosis PMID: 15681610
14. Haspin is required to maintain centromeric cohesion during mitosis. PMID: 17084365

Show More

Hide All

HGNC: 19682

OMIM: 609240

KEGG: hsa:83903

STRING: 9606.ENSP00000325290

UniGene: Hs.534059