Recombinant Human Short transient receptor potential channel 5(TRPC5) ,partial

Code CSB-YP892463HU
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Source Yeast
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Code CSB-EP892463HU
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Source E.coli
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Code CSB-EP892463HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP892463HU
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Source Baculovirus
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Code CSB-MP892463HU
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names TRPC5
Uniprot No. Q9UL62
Alternative Names Htrp 5; Htrp-5; Htrp5; Short transient receptor potential channel 5; Transient receptor potential cation channel subfamily C member 5; Transient receptor potential channel 5; Transient receptor protein 5; TRP 5; TRP-5; TRP5; TRPC 5; TrpC5; TRPC5_HUMAN
Species Homo sapiens (Human)
Protein Length Partial
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
(From Uniprot)
Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion.
Gene References into Functions
  1. Silencing of TRPC5 and inhibition of autophagy reverses adriamycin drug resistance in breast carcinoma via CaMKKbeta/AMPKalpha/mTOR pathway. PMID: 28600513
  2. We demonstrated the essential role of glycolysis in TRPC5 induced chemoresistance in human CRC cells via maintaining [Ca(2+)] i homeostasis. PMID: 29463225
  3. induces the epithelial-mesenchymal transition through the HIF-1alpha-Twist signaling pathway to promote tumor metastasis in colon cancer PMID: 28864720
  4. TrpC5 causes a robust rise in [Ca2+]i, enhanced Wnt5a expression and nuclear translocation of beta-catenin, leading to reduced differentiation and enhanced cancer cell stemness. PMID: 27895148
  5. that Arg-593, a residue located in the E4 loop near the TRPC5 extracellular Gd(3+) binding site, is critical for conferring the sensitivity to GPCR-Gq/11-PLC-dependent gating on TRPC5. PMID: 27920205
  6. Transient receptor potential canonical 5 (TRPC5) protects against pain and vascular inflammation in arthritis and joint inflammation. PMID: 27165180
  7. circulating exosome-carrying TRPC5 might act as a noninvasive chemoresistance marker and might serve as an adjuvant to the current imaging examination-based chemoresistance. PMID: 28032400
  8. The essential role of TrpC5 in GLUT1 induction and chemoresistance in colorectal cancer. PMID: 28000878
  9. TrpC5 plays an important role in VEGF-mediated tumor angiogenesis, suggesting its potential clinical value for anti-angiogenesis therapy PMID: 25579062
  10. TRPC5 mRNA and protein levels were up-regulated in focal cortical dysplasia cortical lesions. PMID: 25085710
  11. Suppressing TrpC5 expression decreased nuclear beta-catenin accumulation, reduced the induction of ABCB1, and reversed 5-fluorouracil neoplastic resistance. PMID: 25404731
  12. these results suggest that hypoosmotic cell-swelling activates Gq-coupled receptors, which in turn enhance the activation of TRPC5 by regulating this channel membrane trafficking PMID: 24177920
  13. Clemizole exhibits a sixfold selectivity for TRPC5. PMID: 25140002
  14. Riluzole can activate TRPC5 heterologously expressed in HEK293 cells as well as those endogenously expressed in the U-87 glioblastoma cell line. PMID: 24117252
  15. TrpC5-containing circulating extracellular vesicles may transfer chemoresistance. PMID: 24733904
  16. Microvesicles from tumor cells transferred TrpC5 to endothelial cells, inducing the expression of P-glycoprotein by activation of the transcription factor NFATc3 (nuclear factor of activated T cells isoform c3). PMID: 24582564
  17. Data using recombinant proteins expressed in vascular endothelial cells suggest that SigmaR1 (sigma 1-type opioid receptor) is not involved in regulation of calcium signaling via TRPC5/TRPM3 (transient receptor potential cation channels C5/M3). PMID: 23121507
  18. Transient receptor potential channel TRPC5 is essential for P-glycoprotein induction in drug-resistant cancer cells. PMID: 22988121
  19. Adipocyte TRPC1 and TRPC5 contribute a constitutively active heteromultimeric channel that negatively regulates adiponectin, and through which the omega-3 fatty acids enhance adiponectin's anti-inflammatory activities. PMID: 22668831
  20. these results suggest that the Galpha(s)-cAMP pathway potentiates the activity of TRPC5 via facilitating intracellular Ca(2+) dynamics and increasing channel trafficking to the plasma membrane. PMID: 22490661
  21. findings demonstrate that highly cold-sensitive TRPC5 channels are a molecular component for detection and regional adaptation to cold temperatures in the peripheral nervous system that is distinct from noxious cold sensing PMID: 22025699
  22. TRPC5 and TRPC6 channels are known as the Ca(2+) influx pathways for a previously described, nonselective, cationic current in podocytes. PMID: 21980113
  23. This study demonstrated a new mechanism of TRPC5 regulation via a cAMP signaling via Galpha(s) and protein kinase A. PMID: 21734191
  24. TRPC5 channel sensitivities to antioxidants and hydroxylated stilbenes. PMID: 21127073
  25. Nitric oxide donors fail to modulate activity of human TRPC5 channels exogenously expressed in HEK293 cells. PMID: 20390293
  26. Stimulation of calcium-permeable TRPC5-containing channels may be an early event in cellular responses to oxidized phospholipids that couples to cell migration and requires an unidentified G protein-coupled receptor. PMID: 20378846
  27. findings suggest intracellular Ca(2+)-calmodulin activates myosin light chain kinase thereby maintaining TRPC5 activity by promotion of membrane TRPC5 distribution under control of phosphorylation/dephosphorylation equilibrium of myoisin light chain PMID: 16284075
  28. TRPC5 calcium channel has a lysophospholipid-sensing capability that confers the property of a lipid ionotropic receptor PMID: 16368680
  29. TRPC-derived pool of calcium contributes to selective activation of calcineurin in diseased heart PMID: 16950785
  30. TRPC5 is a broadly expressed calcium channel with capability to act as an integrator of extracellular and intracellular signals at the level of calcium entry--{REVIEW} PMID: 17217053
  31. TRPC5 calcium channel has a role in bipolar phospholipid sensing [review] PMID: 17233612
  32. TRPC5 is potentiated by protons and may act as a sensor of pH that links decreases in extracellular pH to Ca(2+) entry and depolarization PMID: 17884814
  33. activity of TRPC5 channels may be linked to cellular metabolism via changes in ATP levels and could be involved in Ca(2+) overload occurring after ischemia when ATP is depleted PMID: 17925457
  34. conclusion, TRPC5 is a molecular candidate for NSCC activated by muscarinic receptor stimulation. PMID: 17981154
  35. analysis of a TRPC6-TRPC5 channel cascade that restricts endothelial cell movement PMID: 18495872
  36. Results indicate complex functions for regulation of TRPC5 by PIP2, and suggest that membrane polyphosphoinositides may have at least two distinct functions in regulating TRPC5 channel activity. PMID: 18665391
  37. TRPC5 forms Ca(2+)-activated cation channels that are functionally coupled to Ca(2+)-selective ion channels through local Ca(2+) increases beneath the plasma membrane PMID: 19815560

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Subcellular Location Cell membrane, Multi-pass membrane protein
Protein Families Transient receptor (TC 1.A.4) family, STrpC subfamily, TRPC5 sub-subfamily
Tissue Specificity Expressed in brain with higher levels in fetal brain. Found in cerebellum and occipital pole.
Database Links

HGNC: 12337

OMIM: 300334

KEGG: hsa:7224

STRING: 9606.ENSP00000262839

UniGene: Hs.657709

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