Recombinant Human Solute carrier organic anion transporter family member 4A1 (SLCO4A1), partial

Code CSB-YP822181HU
MSDS
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Source Yeast
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Code CSB-EP822181HU
MSDS
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Source E.coli
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Code CSB-EP822181HU-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP822181HU
MSDS
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Source Baculovirus
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Code CSB-MP822181HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
SLCO4A1
Uniprot No.
Alternative Names
Colon organic anion transporter; OATP-E; OATP-RP1; OATP1; OATP4A1; OATPE; OATPRP1; Organic anion transporter polypeptide-related protein 1; Organic anion-transporting polypeptide E; POAT; SLC21A12; Slco4a1; SO4A1_HUMAN; Sodium-independent organic anion transporter E; Solute carrier family 21 (organic anion transporter) member 12; Solute carrier family 21 member 12; Solute carrier organic anion transporter family member 4A1
Species
Homo sapiens (Human)
Protein Length
Partial
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Mediates the Na(+)-independent transport of organic anions such as the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and of estrone-3-sulfate and taurocholate.
Gene References into Functions
  1. SLCO4A1 may be a valuable marker of poor prognostic for colorectal cancer (CRC). Furthermore, SLCO4A1 plays an important role in CRC cell proliferation, migration, invasion, and carcinogenesis PMID: 28378090
  2. our results revealed altered OATP3A1 and OATP4A1 mRNA levels and novel mechanisms that might be involved in their regulation in colorectal cancer PMID: 26349991
  3. High OATP4A1 expression is associated with small cell lung cancer. PMID: 25301452
  4. oligomerization of Oatp1a1 with PDZK1 is critical for its proper subcellular localization and function PMID: 15994332
Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
Organo anion transporter (TC 2.A.60) family
Tissue Specificity
Ubiquitous, with the exception of spleen and leukocytes.
Database Links

HGNC: 10953

OMIM: 612436

KEGG: hsa:28231

STRING: 9606.ENSP00000217159

UniGene: Hs.235782

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