Recombinant Human Zinc finger protein ZIC 2(ZIC2)

1. Results show that ZIC2 is highly expressed in osteosarcoma cells and tissues, and its overexpression promotes viability, invasion of osteosarcoma cells via SHIP2 suppression, and PI3K/AKT activation. PMID: 28857346
2. the studies confirm the extent of ZIC2 allelic heterogeneity and that pathogenic variants of ZIC2 are associated with both classic and middle interhemispheric variant (MIHV) HPE which arise from defective ventral and dorsal forebrain patterning, respectively. PMID: 29442327
3. miR-1271/Zic2/PAK4 axis plays an important role in hepatocellular carcinoma progression. PMID: 28577975
4. Together SMAD3 and ZIC2 regulate FOXA2 transcription in cultured cells and Zic2 also controls the foxA2 expression during Xenopus development. These findings reveal a new mechanism of NODAL signal transduction in the mammalian node and provide the first molecular explanation of how ZIC2 loss-of-function precipitates Holoprosencephaly (HPE PMID: 27466203
5. Data show that Zinc finger protein ZIC 2 (ZIC2) is indispensable in the regulation of pancreatic ductal adenocarcinoma (PDAC) cell apoptosis. PMID: 26318045
6. ZIC2 acts upstream of OCT4 and recruits the nuclear remodeling factor complex to the OCT4 promoter, initiating OCT4 activation. ZIC2 levels positively correlated to the clinicopathological stages of HCC patients. PMID: 26426078
7. Mutational screening for HPE genes revealed the occurrence of a frameshift mutation in the ZIC2 gene. PMID: 24677696
8. ZIC2 and RASGRF1 are susceptibility genes, not only for common myopia, but also for high myopia. PMID: 24150758
9. The c.1401_1406dup (p.Ala469_470dup) or alanine tract expansion to 17 residues) in the ZIC2 gene are likely to be medically significant for holoprosencephaly in a Brazilian cohort. PMID: 22847929
10. A high level of sequence variation in the 3'UTR of ZIC2 may be associated with holoprosencephaly. PMID: 22859937
11. ZIC2, a transcription factor related to the sonic hedgehog pathway, is a strong discriminant between MAL and LMP tumors: it may be a major determinant of outcome of EOTs. PMID: 22733541
12. Mutations in ZIC2 is associated with holoprosencephaly. PMID: 22310223
13. Brain malformations, including neuronal migration defects, predominated in individuals with ZIC2 mutations. PMID: 21940735
14. role for ZIC2 as a transcriptional regulator of the beta-catenin.TCF4 complex. PMID: 21908606
15. Our findings suggest that Zic2 is a positive modulator increasing Gli1 transcriptional and oncogenic activity by retaining Gli1 in the nucleus of cervical cancer cells. PMID: 21661123
16. mutation of ZIC2 is a rare cause of, or contributor to, RES associated with HPE. PMID: 21638761
17. the smallest 13q deletion associated to DWM allows further narrowing of the previously established critical region for this brain malformation to 13q32.2-32.3. Among the few genes of the deleted region, ZIC2 and ZIC5 seem the most plausible candidates. PMID: 20683983
18. screened four known HPE genes in a Dutch cohort of 86 non-syndromic HPE index cases, including 53 family members. We detected 21 mutations (24.4%), 3 in SHH, 9 in ZIC2 and 9 in SIX3 PMID: 20531442
19. Holoprosencephaly due to ZIC2 mutations is distinct from that due to mutations in other genes. PMID: 19955556
20. ZIC2 expression was associated with the histopathologic types of oral squamous cell carcinoma PMID: 19784848
21. Sample was too small to reach definitive conclusions, but the evidence is sufficiently intriguing to encourage further research. PMID: 11857562
22. Holoprosencephaly in monosomy 13q may be related to ZIC2 gene loss of function. PMID: 11910512
23. Zic2 is an evolutionarily conserved determinant of retinal ganglion cells that project ipsilaterally PMID: 13678579
24. Four novel ZIC2 mutations found in a cohort of Holoprosencephaly patinets. PMID: 15221788
25. The C-terminal alanine-tract of ZIC2 influences the strength of DNA binding and alters transcriptional activity in a promoter-specific manner PMID: 15590697
26. Forms two different complexes with DNA-dependent protein kinase, poly(ADP-ribose) polymerase, and RNA helicase A; all the components interacted directly with Zic2 protein PMID: 17251188
27. This transcription factor regulates the expression of EphB1 in RGCs and also suggest the existence of an additional EphB1-independent pathway controlled by Zic2 that contributes to retinal axon divergence at the midline. PMID: 18417618
28. ZIC2, SPRY2, and GPC5 genes are candidate genes suspected to explain the malformations associated with cerebral anomalies in the hypothesis of a contiguous gene syndrome in 13q deletion syndrome PMID: 19022413
29. Loss-of-function as the likely pathogenetic mechanism common to most, if not all, of ZIC2 mutations in holoprosencephaly. PMID: 19177455

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HGNC: 12873

OMIM: 603073

KEGG: hsa:7546

STRING: 9606.ENSP00000365514

UniGene: Hs.653700