Recombinant Human Zinc transporter ZIP13 (SLC39A13), partial

Code CSB-YP850305HU
MSDS
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Source Yeast
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Code CSB-EP850305HU
MSDS
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Source E.coli
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Code CSB-EP850305HU-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP850305HU
MSDS
Size Pls inquire
Source Baculovirus
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Code CSB-MP850305HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
SLC39A13
Uniprot No.
Alternative Names
FLJ25785; LIV-1 subfamily of ZIP zinc transporter 9; LZT-Hs9; S39AD_HUMAN; SLC39A13; solute carrier family 39 (metal ion transporter), member 13; solute carrier family 39 (zinc transporter), member 13; Solute carrier family 39 member 13; Zinc transporter ZIP13; ZIP-13; Zrt- and Irt-like protein 13
Species
Homo sapiens (Human)
Protein Length
Partial
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Acts as a zinc-influx transporter.
Gene References into Functions
  1. The spondylocheiro dysplastic form of Ehlers-Danlos syndrome, in which ZIP13 is defective, is likely due to a failure of iron delivery to the secretory compartments. PMID: 25006035
  2. Authors demonstrated that both the ZIP13(G64D) and ZIP13(DeltaFLA) protein levels are decreased by degradation via the valosin-containing protein (VCP)-linked ubiquitin proteasome pathway. PMID: 25007800
  3. human ZIP13 releases zinc from vesicular stores PMID: 23213233
  4. Biochemical characterization of human ZIP13 protein: a homo-dimerized zinc transporter involved in the spondylocheiro dysplastic Ehlers-Danlos syndrome. PMID: 21917916
  5. mutations in the SLC39A13 gene do not account for the Ehlers-Danlos syndrome type VIB phenotype PMID: 21739577
  6. clinical features of 6 patients from 2 consanguineous families with Ehlers-Danlos syndrome-like features caused by a mutation in the zinc transporter gene SLC39A13 PMID: 18513683

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Involvement in disease
Ehlers-Danlos syndrome-like spondylocheirodysplasia (SCD-EDS)
Subcellular Location
Golgi apparatus membrane; Multi-pass membrane protein.
Protein Families
ZIP transporter (TC 2.A.5) family
Database Links

HGNC: 20859

OMIM: 608735

KEGG: hsa:91252

STRING: 9606.ENSP00000354689

UniGene: Hs.523664

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