Recombinant Mouse Alpha-crystallin B chain (Cryab)

1. The neuroprotective properties of alpha-crystallin B further demonstrate the potential importance of crystallin proteins in developing therapeutic options for glaucoma. PMID: 29135941
2. It plays a protective and beneficial role in the aging PNS. PMID: 28185662
3. desmin and alphaBeta-crystallin are localized at sarcoplasmic reticulum (SR)-mitochondria-associated membranes (MAMs), where they interact with VDAC, Mic60 - the core component of mitochondrial contact site and cristae organizing system (MICOS) complex - and ATP synthase, suggesting that these associations could be crucial in mitoprotection at different levels. PMID: 27566162
4. this study shows the microglia clusters emerging during experimental autoimmune encephalomyelitis are associated with axonal damage and oligodendrocytes expressing heat-shock protein B5, but not lymphocytes PMID: 27388634
5. This study demonstrated that HspB5 mRNA localization in myelin-enriched white and gray matter PMID: 26718604
6. alphaB-crystallin is an important regulator of epithelial-mesenchymal transition, acting as a molecular chaperone for SMAD4 and as its potential therapeutic target for preventing subretinal fibrosis development in neovascular age-related macular degeneration PMID: 26878210
7. It is a non-Hsp gene, which is essential for HSF1-mediated maintenance of whole body homeostasis. PMID: 26251235
8. A previously unrecognized link between c-Jun and Nrf2 transcription factors and redox-induced CRYAB expression in muscle cells. PMID: 26066304
9. CryAB protects decidualization against stress conditions. PMID: 24951838
10. TNF-alpha-induced endothelial adhesion molecule expression is reduced in inflamed vessels of alphaB-crystallin deficient mice, and leukocyte rolling velocity and IkappaB levels are increased. PMID: 23929007
11. alphaB-crystallin is over-expressed in fibrotic lung tissue and favors TGF-beta1 pathway via its role in modulating the cellular localization of Smad4. PMID: 24307592
12. Data suggest that Cryab plays role in embryo implantation/decidualization; on day 5 of pregnancy when embryo implantation takes place, high level of Cryab mRNA is expressed in subluminal stroma surrounding the implanting blastocyst. PMID: 23579188
13. data collectively demonstrate that alphaB crystallin provides critical protection of mitochondrial function during endoplasmic reticulum stress-induced retinal pigment epithelial apoptosis PMID: 22781655
14. astrocytic DRD2 activation normally suppresses neuroinflammation in the central nervous system through a CRYAB-dependent mechanism PMID: 23242137
15. study suggests a key role of alphaB-crystallin in limiting expansion of CD11b(+) Gr-1(+) IMCs in diverse pathological conditions PMID: 23033322
16. The cardioprotective effects of cryAB are mediated by its translocation from the cytosol to the mitochondria under conditions of oxidative stress and cryAB interactions with VDAC, TOM 20, caspase 3, and caspase 12 may be part of its protective mechanism. PMID: 22904156
17. alphaB-Crystallin expression significantly in hsf1 -/- myocardium compared with hsf1 +/+ myocardium. Hsf1 is the important, but not the only factor, which mediates the constitutively expressed alphaBC. PMID: 21162300
18. Therapeutic effects of systemic administration of chaperone alphaB-crystallin associated with binding proinflammatory plasma proteins. PMID: 22308023
19. increase in apoptosis and reduction in alphaBcrystallin level are involved in the cataractogenesis of MCT mice PMID: 22179185
20. Interestingly, alphaB-crystallin/HspB2 deficient transgenic mice were severely impaired in locomotion compared to each genetic model separately. PMID: 21379584
21. alphaB-crystallin-dependent NF-kappaB activation protects myoblasts from TNF-alpha induced cytoxicity by enhancing the expression of the anti-apoptotic protein, Bcl 2. PMID: 21640763
22. AhR is a regulator of alphaB-crystallin gene expression. PMID: 21494593
23. identification of Cryab as a downstream effector of calcineurin-related protection against myocardial apoptosis PMID: 20937869
24. Hypertrophy-dependent CryAB gene expression can be attributed to a functional linkage between the Jak/STAT and calcineurin/NFAT signalling pathways. PMID: 19538478
25. transient transfection of C2C12(hVEGF165) myoblasts with an anti-alphaB-crystallin siRNA induced a significant decrease (about 75%) in alphaB-crystallin protein levels compared to cells transfectedwith a control siRNA PMID: 20441791
26. there was no evidence of mutant Cu,Zn-superoxide dismutase 1 aggregation in the muscle of mice lacking alpha B-crystallin PMID: 20067574
27. Our studies indicate an important role for alphaB-crystallin as a chaperone for VEGF-A in angiogenesis and its potential as a therapeutic target. PMID: 20023214
28. Data show that alphaB-crystallin modulates myogenesis by altering MyoD level and provide an interesting insight in its role in myogenesis. PMID: 20005263
29. intergenic enhancer elements have orientation-dependent influence on CRYAB PMID: 12403771
30. Phosphorylation-induced activation of alphaB-crystallin. PMID: 12529319
31. molecular chaperone alphaB-crystallin protects cells from acquiring impaired p53 protein and genomic instability PMID: 12826669
32. the protective effect of alphaB-crystallin requires synthesis of the endogenous heat shock proteins PMID: 14523008
33. whereas neither alphaBC nor HSPB2 is essential for myocardial development and function under nonstressful conditions, one or both are required for maximal functional recovery and protection from I/R-induced necrosis and apoptosis. PMID: 14592939
34. loss of z-disk and membrane scaffolding proteins immediately after lengthening contractions, and concomitant translocation of HSP25 and alphaB-crystallin to the z-disk, which may help to stabilize or repair cytoskeletal elements at this site. PMID: 14627610
35. newly identified enhancer with Sox elements activates the alphaB-crystallin promoter in the lens, although they are separated by the entire HSPB2 gene PMID: 15113840
36. PDGF-BB induces phosphorylation of alphaB-crystallin via p38 MAP kinase during myocardial infarction PMID: 15907784
37. This study suggests that, during ischemic insults, alphaB-crystallin/HSPB2 may not be important for the contraction process itself, but rather serve to maintain muscular elasticity. PMID: 16217658
38. These findings indicate an important role of CRYAB and/or HSPB2 in mitochondrial function. PMID: 16678848
39. Results suggest that disturbance of the cytoskeleton leads by converging signaling pathways to the phosphorylation of alphaB-crystallin, which may act as a protective effector of the cytoskeleton. PMID: 16979163
40. In the present study, we reported the early protective role of alphaB-crystallin against hydrogen peroxide-induced apoptosis in mice myogenic C(2)C(12) cells. alphaB-Crystallin interacted with p53. PMID: 17222797
41. Tissue-specific promoter activity can be modulated by changing as few as two apparently neutral nucleotides in the mouse alphaB-crystallin enhancer region. PMID: 17293452
42. Physical conditioning reverses preamyloid oligomer and prolongs survival in Cryab-based desmin-related cardiomyopathy. PMID: 17389375
43. CRYAB is a potent negative regulator acting as a brake on several inflammatory pathways in both the immune system and central nervous system (CNS). PMID: 17568699
44. CryAB and HSPB2 proteins play nonredundant roles in the heart, CryAB in structural remodeling and HSPB2 in maintaining energetic balance PMID: 17846079
45. We discuss the implications of these disparate results in the context of phenotypic responses reported for CRYAB/HSPB2-deficient mice to different ischemic challenges. PMID: 17873008
46. mouse alphaB-crystallin and MKBP/HspB2 promoter activities are regulated by shared and gene specific intergenic elements PMID: 17939115
47. Mitochondria may be a key component in stressed cells with which phosphorylated alphaB-Cystallin interacts to reduce myocardial ischemia/reperfusion injury. PMID: 17993600
48. Mutant CryAB (CryAB(R120G)) triggered a >2-fold increase in cardiomyocyte autophagic activity, and blunting autophagy increased the rate of aggregate accumulation and the abundance of insoluble CryAB(R120G)-associated aggregates PMID: 18621691
49. CryAB overexpression is benign, whereas the knockout is detrimental to the heart as reflected by cardiac hypertrophy and malfunction in mice at 10 weeks of age. PMID: 18974385
50. In Alexander disease mouse models that loss of Cryab results in increased mortality, whereas elevation of Cryab rescues animals from terminal seizures. PMID: 19129171

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KEGG: mmu:12955

STRING: 10090.ENSMUSP00000034562

UniGene: Mm.178