Recombinant Mouse B-cell CLL/lymphoma 6 member B protein (Bcl6b)

Code CSB-YP002626MO
MSDS
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Source Yeast
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Code CSB-EP002626MO
MSDS
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Source E.coli
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Code CSB-EP002626MO-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP002626MO
MSDS
Size Pls inquire
Source Baculovirus
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Code CSB-MP002626MO
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
Bcl6b
Uniprot No.
Alternative Names
Bcl6b; BazfB-cell CLL/lymphoma 6 member B protein; Bcl6-associated zinc finger protein
Species
Mus musculus (Mouse)
Expression Region
1-474
Target Protein Sequence
MGSTAAPEGA LGYVREFTRH SSDVLSNLNE LRLRGILTDV TLLVGGQPLR AHKAVLIACS GFFYSIFRGR AGLGVDVLSL PGGPEARGFA PLLDFMYTSR LRLSPATAPA VLAAATYLQM EHVVQACHRF IQASYEPLGI SLRPVEVEPP RPPTVAPPGS PRRSEGHPDP PTESRSCSQG SPSPASPDPK ACNWKKYKFI VLNSQTSQAG SLVGESSGQP CPQARLPSGD EACSSSSSSE EGTTPGLQSR LSLATTTARF KCGALANNSY LFTPRAQETS LPASKQANPP PGSEFFSCQN CEAVAGCSSG LELLAPGDED KPYKCQLCRS AFRYKGNLAS HRTVHTGEKP YRCSICGARF NRPANLKTHS RIHSGEKPYK CETCGSRFVQ VAHLRAHVLI HTGEKPYPCP TCGTRFRHLQ TLKSHVRIHT GEKPYHCDPC GLHFRHKSQL RLHLRQKHGA ATNTKVRYHI LGGP
Protein Length
Full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Acts as a sequence-specific transcriptional repressor in association with BCL6. Necessary for activation of naive T-cells to antigenic stimulation. May attenuate the regulatory effect of BCL6 on antigenic activation of naive CD4 T-cells by forming a heterodimer with BCL6.
Gene References into Functions
  1. Mouse germline stem (GS) cell transfected with an activated form of Map2k1 have upregulated Etv5 and Bcl6b gene expression. PMID: 22491947
  2. represses Bcl6-dependent transcription. PMID: 12659862
  3. BCL6b is required for the enhanced magnitude of the secondary response of memory CD8(+) T cells. PMID: 15833813
  4. Both BCL-6 and BAZF regulate hematopoietic progenitor cells homeostasis by an indirect pathway involving CD8 T cells. PMID: 17526724
  5. GDNF up-regulation of Bcl6b, Erm, and Lhx1 expression through Src family kinase signaling is a key component of the intracellular mechanism for spermatogonial stem cells self-renewal. PMID: 17597063
  6. DNA-binding protein; gene expression regulation; binds STAT6 elements; binding site specificity PMID: 11374866

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Subcellular Location
Nucleus.
Tissue Specificity
Ubiquitously expressed with higher expression found in heart and lung.
Database Links
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