Recombinant Mouse Cone-rod homeobox protein (Crx)

1. CRX is required for chromatin remodeling at only a subset of its binding sites, which undergo retina or neuronal specific activation during photoreceptor differentiation. PMID: 30068366
2. proteins involved in phototransduction were not detected in the Crx(-/-) mouse; in this phenotype, however, proteins from spots showing diurnal rhythms were specifically identified as enzymes involved in glucose metabolism, Krebs cycle, and mitochondrial enzymes. PMID: 28371363
3. The L253X mouse provides a valuable model for CRX-associated retinopathy. The pathogenicity of CRX frameshift mutations depends on the position of the premature termination codon, which in turn determines the degree of mutant mRNA/protein overproduction. PMID: 28903150
4. CRX-associated retinopathies stem from graded changes in photoreceptor gene expression, which could significantly contribute to phenotypic variability. PMID: 26324254
5. Rax and Crx cooperatively transactivate Rhodopsin and cone opsin promoters and an optimum Rax expression level to transactivate photoreceptor gene expression exists. PMID: 25986607
6. E168d2 and R90W are mechanistically distinct mouse models for CRX-associated disease that will allow the elucidation of molecular mechanisms and testing of novel therapeutic approaches for different forms of CRX-associated disease. PMID: 24516401
7. The rhythmic nature of pineal CRX protein may directly modulate the daily profile of Aanat expression by inducing nighttime expression of this enzyme, facilitating nocturnal melatonin synthesis PMID: 24877634
8. We conclude that nucleotide changes in evolutionary conserved crx binding site could impact retina-specific expression levels of Kcnv2. PMID: 24664678
9. In Crx-knockout mice vasopressin mRNA expression in the suprachiasmatic nucleus shows significant daily rhythm. PMID: 23784879
10. Data have identified a novel retinal SAM domain protein, Samd7, which could act as a transcriptional repressor involved in fine-tuning of Crx-regulated gene expression. PMID: 23565263
11. Our results show that NRL and CRX together control the expression of most, if not all, genes involved in rod phototransduction through a cis-regulatory module PMID: 22511886
12. Crx broadly modulates the pineal transcriptome and also influences differential night/day gene expression in this tissue PMID: 21797868
13. A change in the suprachiasmatic nuclei of the Crx-deficient mouse might explain the observed circadian differences between the knockout mouse and wild-type mouse. PMID: 20438719
14. CRX combinatorially orchestrates the transcriptional networks of both rods and cones by coordinating the expression of photoreceptor genes including most retinal disease genes. PMID: 20693478
15. Studies isolated Panky/Ankrd33, a gene encoding an ankyrin repeat-containing protein and that PANKY inhibited the DNA-binding activity of CRX. PMID: 20026326
16. CRX has a role in retinal and pineal lineage tumors PMID: 19936203
17. Crx is expressed very soon after a cell fated to be a photoreceptor cell becomes postmitotic. PMID: 19882727
18. the mouse Crx 5'-upstream genomic sequence is capable of directing a cell-specific and developmentally regulated expression of Crx in photoreceptor cells PMID: 11880494
19. both Nrl and Crx are required for full transcriptional activity of the PDE6A gene PMID: 15001570
20. Crx plays an essential role in photoreceptor development and extends our understanding of the pathology of Leber's congenital amaurosis. PMID: 15676071
21. results indicate that photoreceptor-specific gene transcription is controlled by the combinatorial action of Sp4 and Crx PMID: 15781457
22. Crx activates opsin transcription by recruiting HAT-containing co-activators and promoting histone acetylation. PMID: 17656371
23. Crx halted proliferation of retinal stem cells and induced them to differentiate into cells expressing photoreceptor-specific markers PMID: 18172122

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KEGG: mmu:12951

STRING: 10090.ENSMUSP00000126642

UniGene: Mm.441911