Recombinant Mouse Cyclin-dependent kinase 2-associated protein 1 (Cdk2ap1)

Code CSB-YP005062MO
MSDS
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Source Yeast
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Code CSB-EP005062MO
MSDS
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Source E.coli
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Code CSB-EP005062MO-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP005062MO
MSDS
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Source Baculovirus
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Code CSB-MP005062MO
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
Cdk2ap1
Uniprot No.
Alternative Names
Cdk2ap1; Cdkap1; Doc1Cyclin-dependent kinase 2-associated protein 1; CDK2-associated protein 1; Deleted in oral cancer 1; DOC-1; Putative oral cancer suppressor
Species
Mus musculus (Mouse)
Expression Region
1-114
Target Protein Sequence
MSYKPNLTAH MPAAALNAGS VHSPSTSMAT SSQYRQLLSD YGPPSLGYTQ GTGNSQVPQS KYAELLAIIE ELGKEIRPTY AGSKSAMERL KRGIIHARSL VRECLAETER NARS
Protein Length
Full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
specific inhibitor of the cell-cycle kinase CDK2.
Gene References into Functions
  1. Cdk2ap1 expression is primarily regulated by progesterone and the progesterone receptor in uterus and is mainly localized to proliferating tissues. PMID: 20354353
  2. Results indicate that DOC-1 is a bona fide subunit of the Mi-2/NuRD chromatin remodeling complex. PMID: 20523938
  3. (CDK2-AP1) is a potential gene therapeutic agent for oral/head and neck cancer in conjunction with DNA-damaging agents such as cisplatin. PMID: 15543230
  4. p12CDK2-AP1 forms nuclear homodimers in contact inhibited normal diploid cells and dimerization of p12 is a necessary process for the growth inhibition effect by p12 PMID: 15840587
  5. Results suggest that overexpression of CDK2-associating protein 1 (p12CDK2AP1) leads to testicular and ovarian abnormalities, a phenotype closely related to that of cdk2-/- mice. PMID: 16496417
  6. Cdk2ap1 plays an essential role in the early stage of embryogenesis and has a potential role during craniofacial morphogenesis. PMID: 19229340
  7. CDK2AP1-mediated differentiation of murine embryonic stem cell was elicited through the regulation of pRb. PMID: 19564334

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Protein Families
CDK2AP family
Database Links
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