Recombinant Mouse Cyclin-dependent kinase-like 5 (Cdkl5), partial

1. Study provides a comprehensive overview of neurobehavioral phenotypes of heterozygous female Cdkl5 +/- mice and demonstrates that the heterozygous female might be a valuable animal model in preclinical studies on CDKL5 disorder. PMID: 29977282
2. This study showed that the loss of CDKL5 causes breathing deficiency, supporting a CDKL5-mediated regulation of respiratory function in mice. PMID: 29208534
3. CDKL5 plays significant roles in regulating emotional behaviors especially on anxiety- and fear-related responses PMID: 29702698
4. Study generated the Cdkl5 KO mice, and identified hyperexcitability in response to NMDA and postsynaptic overaccumulation of GluN2B-containing NMDARs in the hippocampus. The GluN2B-selective antagonist ifenprodil abrogated the NMDA-induced hyperexcitability of Cdkl5 KO mice. These data indicate that CDKL5 plays an important role in controlling postsynaptic localization of the GluN2B-SAP102 complex in the hippocampus. PMID: 28688852
5. Findings support that CDKL5 plays a role in the comorbid features of autism and ADHD, and mice lacking CDKL5 may serve as an animal model to study the molecular and circuit mechanisms underlying autism-ADHD comorbidity. PMID: 29016850
6. data demonstrate that sleep apneas are a core feature of CDKL5 disorder and a respiratory biomarker of CDKL5 deficiency in mice, and suggest that sleep-disordered breathing should be evaluated routinely in CDKL5 patients PMID: 28230307
7. The data of this study demonstrate that dendritic spine stabilization is strongly regulated by CDKL5. PMID: 26452614
8. Our findings demonstrate that CDKL5 is an important regulator of synaptic function in glutamatergic neurons and serves a critical role in learning and memory. PMID: 28674172
9. We have characterised the predominant brain isoform of CDKL5, a 9.7 kb transcript comprised of 18 exons with a large 6.6 kb 3'-untranslated region (UTR), which we name hCDKL5_1. In addition we describe new exonic regions and a range of novel splice and UTR isoforms PMID: 27315173
10. Taken together, these results strongly suggested that DYRK1A bound to CDKL5 and phosphorylated it on Ser-308, thus interfering with its nuclear localization. PMID: 27840050
11. CDKL5 deletion during development more markedly impairs the establishment of a correct GABAergic cerebellar network than that of glutamatergic one, leading to the behavioural symptoms associated with CDKL5 mutation. PMID: 27108663
12. Findings highlight a critical role of CDKL5 in the fundamental processes of brain development, namely neuronal precursor proliferation, survival and maturation PMID: 24952363
13. Amph1 is the cytoplasmic substrate for CDKL5. PMID: 23651931
14. CDKL5 regulates signal transduction pathways and mediates autistic-like phenotypes. PMID: 23236174
15. a functional axis between MYCN and CDKL5 governing both neuron proliferation rate and differentiation. PMID: 22921766
16. CDKL5 is localized at excitatory synapses and contributes to correct dendritic spine structure and synapse activity. PMID: 22922712
17. both subcellular localization and expression of CDKL5 are modulated by the activation of extrasynaptic N-methyl-D-aspartate receptors and suggest regulation of CDKL5 by cell death pathways. PMID: 21832092
18. CDKL5 is involved in pre-mRNA processing, by controlling splicing factor dynamics. PMID: 19740913
19. CDKL5 phosphorylation is required for its entrance into the nucleus whereas a portion of the COOH-terminal domain is responsible for a stable residency in this cellular compartment probably through protein-protein interactions PMID: 16935860
20. CDKL5 expression is modulated during neuronal development and its subcellular distribution is tightly regulated by the C-terminal tail PMID: 18701457
21. Cyclin-dependent kinase-like 5 in mouse brain could bind to the N-terminal domain of Dnmt1. PMID: 18977197

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KEGG: mmu:382253

STRING: 10090.ENSMUSP00000084342

UniGene: Mm.443717