Recombinant Mouse Cytoplasmic aconitate hydratase (Aco1), partial

1. IL-6 likely up-regulates IRP1 and DMT1 expression and down-regulates FPN1 expression in BV2 microglial cells through JNK signaling pathways PMID: 28672025
2. Using whole RNA sequencing of bone marrow cells in iron-overloaded mice, it was observed that Idh1 and Aco1, enzymes involved in the TCA cycle, were elevated. PMID: 27380194
3. The Irp1-/- mice develop polycythemia and pulmonary hypertension, and suggesting that Irp1 plays an essential role in erythropoiesis and in the pulmonary and cardiovascular systems. PMID: 25771171
4. IRP1 and IRP2 mutant mice rapidly succumb to systemic infection with Salmonella Typhimurium, a pathogenic bacterium that multiplies within macrophages, with increased bacterial burdens in liver and spleen. PMID: 26190773
5. results uncover an unexpected protective role of IRP1 in pathological conditions associated with altered Fe-S metabolism PMID: 25651183
6. Aco1 KD in fully differentiated 3T3-L1 adipocytes decreased lipogenic, Idh1, Adipoq, and Glut4 gene expression. PMID: 25550467
7. impaired mitochondrial [Fe-S] cluster biogenesis in Mfrn1(gt/gt) cells results in elevated IRP1 RNA-binding that attenuates ALAS2 mRNA translation and protoporphyrin accumulation PMID: 24509859
8. Data indicate that JTR-009, a benzimidazole, operated by preventing iron-regulatory protein-1 (IRP1) from binding to the iron-responsive element (IRE) in APP mRNA. PMID: 23935819
9. Human ACO1 is a moonlighting protein that has both aconitase enzyme activity as well as an mRNA binding function. PMID: 8041788
10. Aco1 is a moonlighting protein that has aconitase activity as well as mRNA binding ability. PMID: 1946430
11. IRP1 is the principal regulator of HIF2alpha mRNA translation PMID: 23777768
12. Irp1 deletion enhanced HIF2alpha protein expression in kidneys of Irp1(-/-) mice. PMID: 23395173
13. These results uncover separable physiological roles of each IRP and identify IRP1 as a therapeutic target for manipulating HIF-2alpha action in hematologic, oncologic, and other disorders. PMID: 23395174
14. The RNA-binding and aconitase forms of IRP-1 can undergo interconversion dependent on the density of cells growing in culture. PMID: 22544036
15. aconitase functions as a licensing factor in ERK-dependent proliferation and differentiation, thereby providing a regulatory input for iron in EPO-dependent erythropoiesis. PMID: 21887333
16. A wide network of mRNAs and proteins with iron-dependent regulation, IRP-dependent regulation, or both. PMID: 21940823
17. Iron regulatory protein 1 outcompetes iron regulatory protein 2 in regulating cellular iron homeostasis in response to nitric oxide. PMID: 21566147
18. Mice lacking both IRP1 in their hepatocytes suffer from mitochondrial iron deficiency and dysfunction associated with alterations of the ISC and heme biosynthetic pathways, leading to liver failure and death. PMID: 20674864
19. Iron regulatory protein-1 (Irp1)/aconitase activities studied in macrophages grown under control conditions or subjected to iron starvation or supplementation show that Irp1 is activated by direct disassembly of the Fe-S cluster of cytoplasmic aconitase. PMID: 12044177
20. A comparative study of the roles of iron regulatory proteins 1 and 2 in regulating iron metabolism. PMID: 14726953
21. targeted mutagenesis; mice that are homozygous for the correctly modified IRP1 or IRP2 alleles, respectively, display a strong reduction (90%, IRP1(-/-)) or nondetectable levels (IRP2(-/-)) of the targeted proteins PMID: 15208438
22. IRP1 is nitrated in nitric oxide-producing murine macrophages PMID: 15258160
23. under conditions of O2*- -mediated oxidative stress, IRP1 is not essential for the maintenance of iron metabolism in mammals PMID: 15557328
24. Cytosolic Fe-S cluster aconitase activity of iron regulatory protein-1 progressively decreases in Friedreich ataxia PMID: 15615771
25. Removal of nitric oxide resulted in a reverse regulation of IRP1 activities accompanied by a decrease of labile iron pool PMID: 15629469
26. IRP1 controls iron homeostasis during cell proliferation, inflammation, and in response to diseases altering cytosolic Fe-S cluster assembly or disassembly. PMID: 16424901
27. IRP-1,-2 are indispensable for regulation of mammalian iron homeostasis at the post-implantation stage of murine embryonic development PMID: 16480904
28. Data show that IRP1 are thus essential for intestinal function and organismal survival and coordinate the synthesis of key iron metabolism proteins in the duodenum. PMID: 18177727
29. IRP1 and IRP2 increase neuronal vulnerability to oxidative injury. PMID: 18655771
30. the response of Irp1 (-/-) and Irp2 (-/-) mice to acute local inflammation is largely preserved PMID: 19533074

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KEGG: mmu:11428

STRING: 10090.ENSMUSP00000100038

UniGene: Mm.331547