Recombinant Mouse DNA (cytosine-5)-methyltransferase 3B (Dnmt3b), partial

1. a new paradigm of transcriptional regulation critical for cardiac development and maturation that is controlled by the interaction of REST, DNMT3B and non-CpG methylation. PMID: 27956497
2. Together, this study described the regulation of Chk2 expression through promoter methylation by Dnmt3b and also presented a novel role of Chk2 during neuronal differentiation, which is independent of its previously known function in DNA damage response. PMID: 28712951
3. in mouse embryonic stem cells, Dnmt3b-dependent intragenic DNA methylation protects the gene body from spurious RNA polymerase II entry and cryptic transcription initiation PMID: 28225755
4. Mechanical stimulation regulates osteoblastic genes expression via direct regulation of Dnmt3b. PMID: 28215635
5. a miR-125b-DNMT3b-p53 signal pathway may exist in the vascular smooth muscle cells proliferation induced by homocysteine. PMID: 27426728
6. Loss of DNMT3B results in hypomethylation of the miR-196b promoter and increased miR-196b expression, which directly targets the mTORC2 component Rictor. PMID: 26923591
7. Downregulation of DNMT3B, one of the targets identified using this method, radiosensitizes cancer cells by disturbing multiple DNA damage responses. PMID: 26667181
8. High levels of Dnmt3b expression prolong leukemia latency. PMID: 26729896
9. we report that cardiac specific deletion of Dnmt3b, the predominant DNA methyltransferase in adult mouse hearts, leads to an accelerated progression to severe systolic insufficiency and myocardial thinning without a preceding hypertrophic response. PMID: 25784084
10. Dnmt3b-deficient cells can contribute to the male and female germ-lines in chimeric mice and can produce normal progeny, establishing that Dnmt3b is dispensable for mouse gametogenesis and imprinting. PMID: 20132320
11. THC in WT mice increased promoter methylation of DNMT3a and DNMT3b in THC-induced myeloid-derived suppressor cells, reducing expression of DNMT3a and DNMT3b. PMID: 25713087
12. findings reveal how sequence and chromatin cues guide de novo methyltransferase activity to ensure methylome integrity PMID: 25607372
13. DNMT3b plays an important role in regulating macrophage polarization through epigenetic mechanisms. PMID: 24597547
14. hyperglycemia-induced oxidative stress stimulates Dnmt3b activity, inhibiting chromatin modifications necessary for Pax3 expression during neurulation, providing a molecular mechanism for defects caused by Pax3 insufficiency in diabetic pregnancy. PMID: 24834974
15. This sudy demonistrated that Dnmt3b-deficient induced pluripotent stem cells (iPSCs). Single-cell expression analysis revealed that individual Dnmt3b-deficient Purkinje cells expressed increased numbers of Pcdh isoforms. PMID: 24698270
16. Mice that are homozygous for the Dnmt3b mutant have smaller stature and reduced viability but dis not have cumulative effects across generations. PMID: 23636699
17. Aldosterone stimulates the dispersal of DNMT3b and recruitment of Tet2 to demethylate the alphaENaC promoter, thereby inducing alphaENaC transcription in kidney collecting duct cells. PMID: 23926181
18. feeding and hepatic clockwork regulate diurnal variation in Dnmt3b expression. PMID: 22847467
19. Dnmt3b can act as a haploinsufficient tumor suppressor gene. PMID: 23315164
20. DNA methyltransferase 3b is dispensable for mouse neural crest development. PMID: 23094090
21. Dnmt3b is distributed in both the heterochromatin and euchromatin regions. PMID: 15533817
22. We observe evidence for a context-dependent contribution of Dnmt3b to set and maintain CpG and non-CpG methylation at distinct classes of repetitive elements and selected single copy genes PMID: 22761581
23. identify Ment (Gm128) as an enhancer of lymphomagenesis that contributes to the tumor suppressor function of Dnmt3b PMID: 22133874
24. Dnmt3bDelta6 could induce a hypomethylation status especially in in vitro manipulated embryos. PMID: 21666347
25. In mouse embryonic stem cells, the genes upregulated after deletion of the H3K9 methyltransferase Setdb1 are distinct from those derepressed in mESC deficient in the Dnmt3b, with the exception of a small number of primarily germline-specific genes. PMID: 21624812
26. DNA methyltransferase 3b methylates genes in a similar way in mouse intestine and human colon cancer PMID: 21490393
27. Results reveal a compelling new mechanism of RNA-dependent DNA methylation, suggesting that recruitment of DNMT3b by DNA:RNA triplexes may be a common and generally used pathway in epigenetic regulation. PMID: 20952535
28. Dnmt3b recruitment through E2F6 transcriptional repressor mediates germ-line gene silencing in murine somatic tissues. PMID: 20439742
29. Lsh is required for establishment of DNA methylation patterns at stem cell genes during differentiation, in part by regulating access of Dnmt3b to its genomic targets. PMID: 19650037
30. crystal structure: PWWP domain of DNA methyltransferase Dnmt3b defines a new family of DNA-binding folds PMID: 11836534
31. Dnmt3b is not responsible for maintenance-coupled de novo methylation in mouse cells PMID: 12370304
32. DNMT3b plays an important role in neoplastic transformation PMID: 12879017
33. Dnmt3b important for the early phase of neurogenesis. PMID: 15672446
34. Constitutive or conditional deletion of Dnmt3b, but not Dnmt3a, results in partial loss of DNA methylation throughout the genome, suggesting that Dnmt3b is required for maintaining DNA methylation in mouse embryonic fibroblasts. PMID: 15757890
35. Dnmt3b plays an essential role at different stages of mouse development, and that Immunodeficiency, Centromeric instability and Facial anomalies missense mutations cause partial loss of function PMID: 16501171
36. Deletion of Dnmt3b results in suppression of intestinal neoplasms. PMID: 16581773
37. The Dnmt3b genes showing marginal correlation (-.4 < p(s) < .6) were present in the early stages of differentiation of both GD and RD, which were non-specific to brain development. PMID: 16627687
38. Transcripts are at their highest levels in type A spermatogonia, decrease dramatically in type B spermatogonia and preleptotene spermatocytes and rise again in leptotene/zygotene spermatocytes. PMID: 16725135
39. Dnmt3b is specifically expressed in progenitor cells during hematopoiesis, spermatogenesis and neurogenesis, suggesting an important role in the initial steps of progenitor cell differentiation. PMID: 16973295
40. dnmt3b is coordinately regulated and its expression peaks during the stage of postnatal oocyte development when maternal methylation imprints are established PMID: 17445268
41. Could cooperate with the orphan receptor COUP-TFI and Dnmt3a to regulate transcription of the vitronectin gene. PMID: 17579209
42. Both Dnmt3a and Dnmt3b were involved in the methylation of Rasgrf1 DMR and long interspersed repeats IAP and Line1, but only Dnmt3b was required for the methylation of the satellite repeats. PMID: 17616512
43. Dnmt3b1 enhanced the number of colon tumors in Apc Min/+ mice approximately twofold and increased the average size of colonic microadenomas, whereas Dnmt3a1 had no effect. PMID: 18056424
44. Data report the characterization of interactions between Dnmt3b and both thymine-DNA glycosylase (Tdg) and methyl-CpG binding domain protein 4. PMID: 18452947
45. Insufficient methylation of the DNMT3L promoter during embryonic development due to deficiency in DNMT3B might be implicated in the pathogenesis of the ICF syndrome (characterized by immunodeficiency, centromere instability and facial anomalies). PMID: 18544626

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KEGG: mmu:13436

STRING: 10090.ENSMUSP00000051830

UniGene: Mm.491804