Recombinant Mouse Disabled homolog 1 (Dab1)

1. Deletion of Dab1 in endothelial cells leads to a reduced secretion of laminin-alpha4 and decreased activation of integrin-beta1 in glial cells, which in turn control neuronal migration and barrier properties of the neurovascular unit. PMID: 30139844
2. In intestine a truncated Dab1 variant transmits the reelin signal and may play a role in clathrin-mediated apical endocytosis and in the control of cell-to-cell junction assembly. Dab1 variant may be a nucleocytoplasmic shuttling protein, inferred from its sequence and nuclear location. PMID: 29470947
3. These observations suggest that the morphogenesis in these hippocampal formation subdivisions employs different developmental mechanisms involving Dab1 function. PMID: 28945921
4. These results suggest that deficiency of Reelin-Dab1 signal in the dorsal forebrain is involved in the pathogenesis of some symptoms of human psychiatric disorders. PMID: 26762856
5. RBX2, a core component of the E3 ubiquitin ligase CRL5, is essential for retinal layering and function. RBX2 regulates the final cell position of rod bipolar cells, cone photoreceptors and Muller glia. Our data indicate that sustained RELN/DAB1 signaling, triggered by depletion of RBX2 or SOCS7 - a CRL5 substrate adaptor known to recruit DAB1 - causes rod bipolar cell misposition. PMID: 29361558
6. Mice with low or no Dab1 expression exhibited reduced calling rates, altered call-type usage, and differential vocal development trajectories. PMID: 27184477
7. Results showed that the Dab1 nuclear localization signal mutant can translocate into the nucleus via an unconventional temperature-dependent/ATP-dependent and cytoplasmic soluble factor-independent/RanGTP gradient-independent manner, suggesting that Dab1 has 2 different nuclear translocation pathways; and that the regulation of subcellular localization of Dab1 is important for the proper migration of excitatory neurons. PMID: 26209842
8. This study showed that spontaneous Dab1 mutations causing cerebellar pathology are impaired in motor functions during the neonatal period. PMID: 25907855
9. an aberrant fragment of Dab1 protein (p64/60) is present in the brain of yotari mouse PMID: 25149914
10. When pregnant mice are exposed to EMF, Dab1 expression increases in the EMF-treated fetal cerebral cortex extracts as compared to controls and SHAM group. PMID: 24584565
11. It findings link reelin with Dab1 and suggest that Dab1 functions downstream of reelin action on the homeostasis of the crypt-villus unit. PMID: 24313315
12. The results of this study indicate a causal relation between the downregulation of Dab1 protein levels during development and the structural and behavioral deficits associated with psychiatric diseases in the adult. PMID: 24030361
13. Suggest role for reelin/DAB-1 signaling promoting chondrogenic differentiation of digit mesodermal progenitors in embryonic limbs. PMID: 24519818
14. results suggest a major role of VEGF in the regulation of reelin signaling, and Dab1 as a key molecule in the cross talk between reelin and VEGF signaling pathways. PMID: 23916658
15. Dab1 is specifically knocked out in immature neurons while it remains active in glial cells. PMID: 23828756
16. The expression of Dab-1 was analyzed in the developing mouse autopod. Transcripts of Dab-1 were abundant in the autopodial tendon primordia, but transcripts were also present in the undifferentiated mesoderm located around the digits. PMID: 24519818
17. Dab1 mediated the association of CIN85 with ApoER2 or VLDLR in neurons. PMID: 23506116
18. Dab1 is a critical regulator of synaptic function and hippocampal-dependent associative and spatial learning. PMID: 24068831
19. These results indicate a crucial participation of the basal ganglia in the functional phenotype of ataxic Dab1(scm) mutants. PMID: 23707934
20. Reeler and scrambler (Dab1) mutant neurites extend tangentially rather than radially, and the Golgi apparatus that normally invests the apical neurite is compact in both reeler and scrambler mutants. PMID: 22770513
21. Data suggest that Ser587 Cin85 (Cbl-interacting protein of 85 kDa; SH3-domain kinase binding protein 1) phosphomimetic mutant protein shows dramatically reduced binding to Dab1 (without affecting binding to CapZ). PMID: 23178720
22. This study demonistrated that Dab1(scm) (scrambler) mutant mice show the Abnormal grooming activity. PMID: 22561124
23. coordinated expression of specific Dab1 isoforms in different populations of cells in the developing brain contributes to precise neuronal migration by modulating the activity of subsets of Dab1 downstream effectors PMID: 22586277
24. learning deficiencies found in Dab1 mutant mice reproduce the phenotype previously reported in Relnrl-Orl mutants PMID: 22245534
25. Data suggest that HGF is essential for reelin and Disabled 1 expression in the cerebral cortex of the newborn mouse. PMID: 21701912
26. strong and consistent Dab1 mRNA and protein expressions, throughout the olfactory bulb layers in both wild type and reeler mice PMID: 22046330
27. despite massive cerebellar degeneration in Dab1 mutant mice, sensorimotor learning for equilibrium is still possible PMID: 21167868
28. Isolated mammary epithelial cells exhibited decreased migration in response to exogenous reelin in vitro, a response that required Dab1 PMID: 21266412
29. [LINK this protein (mouse disabled-1) that you indexed & described in your link of ApoER2] PMID: 21048135
30. A stabilized degradation-resistant mutant of Disabled-1 (Dab1) causes overmigration of embryonic cortical neurons. PMID: 20410119
31. findings suggest Reelin induces phosphorylation at Y185 of Dab1, and that there are two Reelin signaling pathways, phosphorylation of either one of the residues in each pair is sufficient for the transmission of Reelin signaling PMID: 19796633
32. The distribution pattern of corticospinal tract neurons of the reelin/Dab1-compound mutant mouse differs from those of either of the reeler or yotari counterparts. PMID: 19221860
33. Disabled 1 is is affected by Reelin and plays a role in glial differentiation and forebrain development through beta1-integrin dependent signal transduction PMID: 12244214
34. This gene is an intracellular adaptor of the Reelin pathway and reveals unusual complexity in human and mouse. PMID: 12446734
35. Reelin activates Fyn to phosphorylate and downregulate Dab1 during brain development PMID: 12526739
36. Reelin receptor machinery, including ApoER2 and VLDLR and Dab1 protein, is located in radial glia precursors in cortical wall from the ventricular zone to the pial surface. PMID: 12586425
37. Results suggest that Dab1 inhibits the activity of Siah. PMID: 12646221
38. The distribution pattern of layer V neurons differs between reeler and yotari mice, suggesting that the Reelin and Dab1 proteins may play different roles in the migration and cell positioning of layer V neurons. PMID: 12722105
39. the rigid Dab DH domain maintains two independent pockets for binding of the APP/lipoprotein receptors and phosphoinositides PMID: 12826668
40. Dab1 phosphorylation leads to the recruitment of Nck beta to the membrane, where it acts to remodel the actin cytoskeleton PMID: 14517291
41. Results of this study outline the molecular mechanism by which Disabled-1 signaling controls the adhesive property of neurons to radial glia, thereby maintaining proper neuronal positioning during corticogenesis. PMID: 15091337
42. Reelin treatment targets adaptor protein Disabled-1(Dab1) for proteolytic degradation by the ubiquitin-proteasome pathway and signaling through neuronal apolipoprotein E receptor 2 can activate the ubiquitin-proteasome machinery PMID: 15175346
43. Rather than using an allosteric mechanism, the Dab1 phosphotyrosine binding (PTB) domain appears to serve as a scaffold with two independent binding sites ready to accept either ligand without a preferred order of ligand binding. PMID: 15323557
44. Dab1 can complex with the cytoplasmic region of beta1 integrin in a reelin-dependent manner PMID: 15703255
45. Dab1 regulates both cell surface expression and internalization of Reelin receptors PMID: 15718228
46. In Reelin sinaling pathway,ApoER2 and the VLDL receptor-mediated Dab1 phosphorylation does not depend on lipid rafts and phosphorylated Dab1 remains bound to the receptor tail when the pathway is activated by Reelin. PMID: 16354676
47. Data suggest that distal Dab1-immunoreactive cells are misplaced AII amacrine cells, resulting from genetically modulated anomalies owing to migration errors. PMID: 16374803
48. Reelin from other brain regions can substitute for the loss of hippocampal Reelin and that rescue of the reeler phenotype observed in our coculture studies is mediated via lipoprotein receptors for Reelin and Dab1. PMID: 16432903
49. regulates the nuclear position of postmitotic neurons in a phosphorylation-site dependent manner PMID: 16449660
50. cell-autonomous role of Dab1 in dendritogenesis in the neocortex and suggests remodeling of the leading process of a migrating neuron into a nascent dendrite by Reelin/Dab1 signaling plays an important role in cell positioning. PMID: 16467525

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KEGG: mmu:13131

UniGene: Mm.289682