Recombinant Mouse Dual specificity protein phosphatase 1 (Dusp1)

1. Low DUSP1 expression is associated with cerebral ischaemia reperfusion injury. PMID: 30138595
2. Results indicate that the upregulation of anterior cingulate cortex (ACC, areas 24a and 24b) MKP-1 is necessary for the expression of depressive symptoms induced by chronic pain, chronic stress, and optogenetic activation of the ACC. PMID: 28359564
3. The results suggested that DUSP1 gene silencing promoted the release of proinflammatory cytokines through activation of the MAPK signaling pathway in mice with acute pancreatitis. PMID: 29393354
4. The cardiac ischemia/reperfusion injury - induced DUSP1 deficiency promoted the activation of JNK which upregulated the expression of the mitochondrial fission factor (Mff). PMID: 29149759
5. Study demonstrates that MKP-1 serves as a master-regulator of macrophage phenotype and function and its dysregulation by metabolic stress may be a major contributor to atherogenesis and the progression of atherosclerotic plaques. PMID: 27670844
6. FAM3D inhibits glucagon secretion via MKP1-dependent suppression of ERK1/2 signaling. PMID: 28247283
7. these data show that MKP-1 is an important endogenous suppressor of innate immune responses involved in the regulation of blood-testis barrier barrier dynamic PMID: 27783995
8. MKP-1 regulates IL-1beta production through stabilization of HIF-1alpha. The induction of HIF-1alpha protein in MKP-1 deficiency is partly due to p38MAPK activation in response to LPS. PMID: 28238855
9. this work identifies a previously unrecognized role for DUSP1 in regulating autophagy. PMID: 27459239
10. c-FOS and DUSP1 expression levels determine the threshold of tyrosine kinase inhibitor (TKI) efficacy, such that growth-factor-induced expression of c-FOS and DUSP1 confers intrinsic resistance to TKI therapy in a wide-ranging set of leukemias. PMID: 28319094
11. PTHrP counteracts the pro-apoptotic actions of reactive oxygen species by a mechanism dependent on MKP1-induced dephosphorylation. PMID: 27357344
12. A2AR signaling regulates both basal and LPS-induced DUSP1 levels in macrophages via activating the adenylate cyclase pathway. PMID: 27066978
13. these data suggest an important role for DUSPs in regulating MAPK dephosphorylation, with an emphasis on DUSP1, during early adipogenesis PMID: 26566083
14. Loss of DUSP1 does not cause changes in cartilage degeneration and gait in a mouse model of spontaneous osteoarthritis at 21 months of age. PMID: 26562438
15. Nr4a1 induction is dependent on ERK1/2 and that MKP-1 negatively regulates this induction. PMID: 25657047
16. MKP-1 negatively regulates chemokine-driven osteoclast formation and subsequent bone resorption in response to LPS stimulation PMID: 25261746
17. DUSP1 and tristetraprolin cooperate to regulate macrophage responses to lipopolysaccharide. PMID: 26019272
18. MKP-1 regulated the expression of MMP-12. PMID: 25310910
19. CYLD negatively regulates nontypeable Haemophilus influenzae-induced IL-8 expression via MKP-1-dependent inhibition of ERK. PMID: 25389768
20. Ozone exposure decreased the protein expression of MKP-1 in an asthma model. PMID: 25287866
21. hepatic MKP-1 serves as a selective regulator of MAPK-dependent signals that contributes to the maintenance of glucose homeostasis and peripheral tissue energy balance PMID: 25312648
22. MKP-1 and MKP-2 stability is regulated by ERK-mediated phosphorylation through a degradation pathway independent of polyubiquitination PMID: 25204653
23. MKP-1 negatively regulates MAPK signaling in the mouse hypothalamus. PMID: 24686178
24. The results of this study imply that MKP-1 possesses anti-apoptotic and anti-inflammatory properties by simultaneously controlling the activities of JNK and microglial p38. PMID: 24842488
25. DUSP1 is actively involved in the antiviral host defense mechanism against a poxvirus infection. PMID: 24244156
26. MKP-1 promoted angiogenic and arteriogenic neovascular growth, potentially through dephosphorylation of histone H3 serine 10 on coding-region DNA to control transcription of angiogenic genes, such as fractalkine. PMID: 24578378
27. results show that HDAC1, -2, and -3 deacetylate MKP-1 and that this post-translational modification increases MAPK signaling and innate immune signaling PMID: 24374966
28. rapamycin treatment led to an increased MKP1 expression in BMDM from WT but failed to do so in BMDMs lacking the AKT1 isoform or MEK1 and MEK2. PMID: 24126911
29. Mitogen-activated protein kinase phosphatase (Mkp)-1 protects mice against acetaminophen-induced hepatic injury. PMID: 22623522
30. MKP-1 provides neuroprotection in a mouse model of Huntington's disease by inhibiting p38 and JNK kinase. PMID: 23392662
31. Dusp1 and Dusp4 are cardioprotective genes that play a critical role in the heart by dampening p38 MAPK signaling that would otherwise reduce contractility and induce cardiomyopathy. PMID: 22993413
32. Notch3 inhibits the myogenic transcription factor Mef2c by increasing the activity of Mkp1. PMID: 23055528
33. MKP-1 regulates RANKL gene expression and is essential for vitamin D signaling. PMID: 22899855
34. A sexual dimorphism exists in the periapical inflammatory process, where male mkp-1(-/-) mice have more inflammation than female mkp-1(-/-) mice. The increase in inflammatory infiltrate correlates to more bone loss in the male mice. PMID: 22794213
35. The MKP-1 activity is required to exclude C/EBPbeta from the nucleus basally, and that MKP-1 antagonizes C/EBPbeta expression after global forebrain ischemia, particularly within the vulnerable CA1 sector of the hippocampus. PMID: 22522596
36. MKP-1 suppressed Tristetraprolin expression by inhibiting p38 MAPK pathway. PMID: 23030431
37. Data indicate that knockdown of MKP-1 mimicked the priming effects of metabolic stress. PMID: 22991462
38. MKP-1 is regulated the evolution as well as the resolution of inflammation during muscle stem cell-dependent tissue repair by controlling p38-mediated AKT activation. PMID: 22361726
39. mapracorat exerts its anti-inflammatory effects, at least in part, by augmenting MKP-1 expression PMID: 22898817
40. Data revealed that ZFP36L1 and ZFP36L2 bound to the 3' untranslated region (UTR) of MAPK phosphatase-1 (MKP-1) mRNA and downregulated Mkp-1 3'UTR-mediated luciferase activity. PMID: 22701344
41. nocodazole increases the ERK activity to enhance Dusp1(MKP-1) expression which inhibits p38 activation induced by TNF-alpha. PMID: 22294037
42. DUSP-1 is a critical regulator of osteoclast activity and limits bone destruction in an experimental model of rheumatoid arthritis PMID: 22275313
43. GR dimerization inhibits JNK2 through MKP1 and protects from TNF-induced apoptosis and lethal inflammation. PMID: 22585571
44. The results support a pivotal role of Mkp-1 as a negative regulator of mucosal immune responses and highlight its protective function against inflammatory bowel disease. PMID: 22461024
45. MKP-1, one of immediate early genes in stress conditions, was induced at transcriptional level in hypoxia/re-oxygenation in neuroblastoma N1E115 cells. PMID: 22197701
46. MKP1 represents an important negative feedback mechanism limiting pro-inflammatory response in the heart during sepsis. PMID: 22198506
47. Upregulation of MKP-1 by vitamin D is a novel pathway by which vitamin D inhibits lipopolysaccharide-induced p38 MAP kinase activation and cytokine production in monocytes/macrophages. PMID: 22301548
48. Data shows MKP-1 plays an important role in the control of macrophage activation by the adaptive immune system. PMID: 21956667
49. novel regulatory mechanism involving the appropriate balance of p38, MKP-1, miR-21, and AKT activities may have implications in chronic inflammatory degenerative diseases. PMID: 21987635
50. TSA upregulates the expression of C/EBP-beta and MKP-1, which may downregulate pro-osteoclastogenic factors and signaling molecules, ultimately suppressing osteoclastogenesis. PMID: 22172035

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KEGG: mmu:19252

STRING: 10090.ENSMUSP00000025025

UniGene: Mm.239041