Recombinant Mouse Fibroblast growth factor 13(Fgf13)

Code CSB-YP008619MO
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Source Yeast
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Code CSB-EP008619MO
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Source E.coli
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Code CSB-EP008619MO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP008619MO
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Source Baculovirus
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Code CSB-MP008619MO
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Fgf13
Uniprot No. P70377
Alternative Names Fgf13; Fhf2Fibroblast growth factor 13; FGF-13; Fibroblast growth factor homologous factor 2; FHF-2
Species Mus musculus (Mouse)
Expression Region 1-245
Target Protein Sequence MAAAIASSLI RQKRQARERE KSNACKCVSS PSKGKTSCDK NKLNVFSRVK LFGSKKRRRR RPEPQLKGIV TKLYSRQGYH LQLQADGTID GTKDEDSTYT LFNLIPVGLR VVAIQGVQTK LYLAMNSEGY LYTSEHFTPE CKFKESVFEN YYVTYSSMIY RQQQSGRGWY LGLNKEGEIM KGNHVKKNKP AAHFLPKPLK VAMYKEPSLH DLTEFSRSGS GTPTKSRSVS GVLNGGKSMS HNEST
Protein Length Full length protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

Target Data

Function Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules. Through its action on microtubules, may participate to the refinement of axons by negatively regulating axonal and leading processes branching. Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus.; FUNCTION
Gene References into Functions
  1. Autism-related protein MeCP2 regulates FGF13 expression and emotional behaviors PMID: 27916441
  2. FHF2 has an essential role in dictating myocardial excitability and conduction that safeguards against temperature-sensitive conduction failure PMID: 27701382
  3. regulator of caveolae-mediated mechanoprotection and adaptive hypertrophic signaling in cardiomyocytes PMID: 28461495
  4. identified two novel native phosphorylation sites in the C terminus of NaV1.5 that impair FGF13-dependent regulation of channel inactivation and may contribute to CaMKIIdeltac-dependent arrhythmogenic disorders in failing hearts. PMID: 28882890
  5. the FGF13/Nav1.7 complex is essential for sustaining the transmission of noxious heat signals PMID: 28162808
  6. These results implicate that FGF13 is a critical cardiac Na(+) channel modulator and Fgf13 knockout mice have increased arrhythmia susceptibility in the setting of Na(+) channel blockade. PMID: 28119060
  7. FGF13 down-regulated Spry1 protein expression, activating the ERK1/2 pathway by phosphorylation and leading to C2C12 cell differentiation inhibition. PMID: 26230950
  8. Fibroblast growth factor homologous factors (FGF11-14) modulate cardiac calcium channels. PMID: 23804213
  9. FGF13 has a role in hair follicle growth and in the hair cycle PMID: 23603273
  10. Genetic deletion of FGF13 in mice results in neuronal migration defects in both the neocortex and the hippocampus. FGF13-deficient mice also exhibit weakened learning and memory. PMID: 22726441
  11. Fibroblast growth factor homologous factor 13 regulates Na(V)1.5 sodium channels and conduction velocity in murine hearts. PMID: 21817159
  12. FGF-13 may play a role in regulating the function of cells in the bulge region and basal layer of the epidermis. PMID: 15140207

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Subcellular Location Cell projection, filopodium, Cell projection, growth cone, Cell projection, dendrite, Nucleus, Cytoplasm
Protein Families Heparin-binding growth factors family
Tissue Specificity Detected in brain, eye and heart. In brain, the different isoforms display different patterns of expression. Expressed in brain and heart (at protein level). Isoform 3 is highly expressed in cardiac myocytes while isoform 1 is the most abundant in brain.
Database Links

KEGG: mmu:14168

STRING: 10090.ENSMUSP00000033473

UniGene: Mm.7995

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