Recombinant Mouse Heat shock protein beta-2 (Hspb2)

1. HSP27 is a partner of JAK2-STAT5 and a potential therapeutic target in myelofibrosis. PMID: 29650953
2. We found significantly slower retrograde transport of mitochondria in Ser135Phe, Pro39Leu and Arg140Gly mutant Hsp27 expressing motor neurons than in wild type Hsp27 neurons, although anterograde movement velocities remained normal. PMID: 28595321
3. HSP27 expression is upregulated in lung fibroblasts during pulmonary fibrosis, and subsequently, HSP27 modulates lung fibroblast differentiation through the Smad3 and ERK pathways. PMID: 27909724
4. phosphorylated Hsp27 stimulates autophagy and lipid droplet clearance and interacts with STAT3. PMID: 27185187
5. Heat shock proteins 27 and 70 were involved in the protective effect. PMID: 26666831
6. The phosphorylation of S82 of the heat shock protein 27 kDa (HSP27), was especially abundant and consistently upregulated in tissues with delays in freezing as short as 2 minutes. PMID: 26329039
7. HspB2 has roles in maintaining ATP levels and as well as chaperone-dependent functions for metabolic homeostasis PMID: 26465331
8. Hsp27 binding to the 3'UTR of Bim mRNA prevents neuronal death during oxidative stress-induced injury. PMID: 25187648
9. These findings indicate that in mice HSP27 and HSP70 play a key role in the induction of cell-mediated immunity to carcinogenic polyaromatic hydrocarbons PMID: 25840912
10. The myocardium releases HSP27 after global ischemia: the proinflammatory effect of extracellular HSP27 through TLR2 and TLR4. PMID: 24918749
11. protective role for endothelial S1P1R against ischemic acute kidney injury most likely by regulating endothelial barrier integrity and endothelial HSP27 expression PMID: 24025642
12. It plays a protective role against AP-induced liver injury. PMID: 24219791
13. findings reveal a novel role for HSP27 in the maintenance of BBB integrity. PMID: 23469858
14. Spatial learning was impaired in AD model mice rescued by Hsp27 overexpression. PMID: 23605646
15. HSP27 is increased in hyperlipidemic animals treated with reconstituted high-density lipoprotein. PMID: 23117011
16. Heat shock protein-27 attenuates foam cell formation and atherogenesis by down-regulating scavenger receptor-A expression via NF-kappaB signaling. PMID: 23939398
17. Chronic over-expression of HSP27 is atheroprotective in both sexes and coincides with reductions in lesion cholesterol accumulation as well as favorable plaque remodeling. PMID: 23409070
18. Tubular expression of heat-shock protein 27 inhibits fibrogenesis in obstructive nephropathy. PMID: 22971995
19. activation of PP2A or inactivation of the p38MAPK-MAPKAPK2-Hsp27 has a role in survival of cancer stem cells under hypoxia and serum depletion via decrease in PP2A activity PMID: 23185379
20. HSPB2 can be replaced by other members of the multigene small HSP family under basal conditions while HSPB2 is implicated in the regulation of metabolic/mitochondrial function under cardiac stress such pressure overload. PMID: 22870288
21. Hsp27 participates in the maintenance of breast cancer stem cells through regulation of epithelial-mesenchymal transition PMID: 22023707
22. HSP27 may serve as an indicator of stimulus strong enough to show its expression. PMID: 22027643
23. This study demonstrated that HSP27 requires PKD-mediated phosphorylation for its suppression of ASK1 cell death signaling and neuroprotection against ischemic injury. PMID: 22357851
24. these results demonstrate that disruption of the primary cilia structure or function compromises the endothelium through the suppression of hsp27 dependent actin organization and focal adhesion formation PMID: 21837772
25. This suggests that the increased tau phosphorylation at S396/404 and S262 sites may be induced by Hsp27 through enhancement of GSK3beta activity in the mouse cerebellum. PMID: 21544852
26. Dexamethasone inhibits ACh-induced ASM contraction through phosphorylation of p38 MAPK and HSP27 PMID: 20693246
27. These results imply that HspB2 and HspB7 might be up-regulated by ethanol during the short-term differentiation of neural stem cells. PMID: 20871982
28. HSP27 induction is critical for TGF-beta-induced VEGF release in osteoblasts. PMID: 21225223
29. Downregulation of both gene expression and activity of Hsp27 improved oocyte maturation in vitro. PMID: 20465849
30. p27 suppresses Hsp27 and Hsp70 expression at the transcriptional level specifically through JNK2/c-Jun- and HSF-1-dependent pathways upon arsenite exposure, providing additional important molecular mechanisms for the tumor-suppressive function of p27. PMID: 20566634
31. Therapeutic hypothermia cardioprotection is mediated by enhanced Akt/HSP27 phosphorylation and enhanced NO generation, resulting in the attenuation of reactive oxygen species generation and the maintenance of DeltaPsim following ischemia-reperfusion. PMID: 20382860
32. Hspb2 promoter drives Cre expression in spermatocytes of transgenic mice. PMID: 20027617
33. Results provide support for the powerful neuroprotective effects of HSP27 in cerebral ischemia. PMID: 19997117
34. results strongly suggest that glucocorticoid stimulates the induction of neither HSP70 nor HSP90, but HSP27 in osteoblasts, and that p38 MAP kinase is involved in the induction of HSP27 PMID: 12112005
35. intergenic enhancer elements have orientation-dependent influence on MKBP PMID: 12403771
36. AlphaB-crystallin and HSP27 were upregulated in the spinal cord of mutant SOD1 mice compared to mice overexpressing wild-type SOD1. HSP70 levels were normal. PMID: 12430713
37. neuroprotective effects of overexpression in transgenic animals against kainate-induced seizures and hippocampal cell death PMID: 12639970
38. whereas neither alphaBC nor HSPB2 is essential for myocardial development and function under nonstressful conditions, one or both are required for maximal functional recovery and protection from I/R-induced necrosis and apoptosis. PMID: 14592939
39. mice over expressing Heat shock protein 27 (verified by Western blotting analysis) were found to be protected from lethal ischaemia/reperfusion injury compared to their negative littermates PMID: 15309411
40. stathmin expression is disregulated, and Hsp25, Hsp27, and peroxiredoxin 6 are upregulated in a mouse model of familial amyotrophic lateral sclerosis PMID: 15509539
41. This study suggests that, during ischemic insults, alphaB-crystallin/HSPB2 may not be important for the contraction process itself, but rather serve to maintain muscular elasticity. PMID: 16217658
42. Phosphatidylinositol 3-kinase/Protein Kinase B plays a part in the sphingosine 1-phosphate-stimulated induction of HSP27 PMID: 16514645
43. These findings indicate an important role of CRYAB and/or HSPB2 in mitochondrial function. PMID: 16678848
44. The small heat shock protein sHSP27 exists as both dimers and large multimers and is distributed homogeneously throughout the cytoplasm. PMID: 16817323
45. MK2 mediates the incorporation of p38 into the pre-existing complex of hsp27 with Akt PMID: 17015449
46. Study is the first to suggest a differential modulation of Hsp27 activation in vivo and illustrates the diverse effect of Hsp27 on acute versus chronic models of disease. PMID: 17360721
47. first demonstration of a specific interaction between HspB1 and a stratum corneum protein and indicates that HspB1 has chaperone activity during stratum corneum formation PMID: 17439945
48. Findings indicate that Hsp27 may play a key role in resistance to doxorubicin-incuded cardiac dysfunction. PMID: 17481944
49. heat shock protein 27 PMID: 17510974
50. CryAB and HSPB2 proteins play nonredundant roles in the heart, CryAB in structural remodeling and HSPB2 in maintaining energetic balance PMID: 17846079

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KEGG: mmu:69253

STRING: 10090.ENSMUSP00000042374

UniGene: Mm.1980