Recombinant Mouse Hepatocyte growth factor-like protein (Mst1)

1. data revealed that OSM alleviated postinfarction cardiac remodeling and dysfunction by enhancing cardiomyocyte autophagy. OSM holds promise as a therapeutic target in treating HF after MI through Obeta receptor by inhibiting Mst1 phosphorylation. PMID: 27825852
2. The results identify Mst1 as a malefactor in the development of post-infarction cardiac injury and that it acts through the JNK-Drp1-mitochondrial fission pathway. PMID: 29760744
3. The results suggest that melatonin alleviates cardiac remodeling and dysfunction in diabetic cardiomyopathy by upregulating autophagy, limiting apoptosis, and modulating mitochondrial integrity and biogenesis. The mechanisms are associated with Mst1/Sirt3 signaling. PMID: 28480597
4. These data suggest that MSP is an effective inhibitor of inflammation and lipid accumulation in the stressed liver, thereby indicating that MSP has a key regulatory role in non-alcoholic steatohepatitis. PMID: 27609031
5. kinases, including Slk, Lok and Mst1, are inhibited by BI-D1870 but to a much lesser extent by BIX 02565 and that phosphorylation of some of their substrates is blocked by BI-D1870 in living cells. PMID: 27919044
6. Nicorandil alleviates post-MI cardiac dysfunction and remodeling. The mechanisms were associated with enhancing autophagy and inhibiting apoptosis through Mst1 inhibition. PMID: 29127009
7. Using a standard two-thirds partial hepatectomy (PH) model in young and aged mice, the activity of the core kinases MST1 and LATS1 increased during the early hypertrophic phase and returned to steady state levels in the proliferative phase, coinciding with activation of YAP1 target genes and hepatocyte proliferation. PMID: 27940445
8. The MST1 acts as a molecular brake to maintain immune tolerance by regulating T cell-mediated B cell activation. PMID: 28527887
9. Mst1 knockout alleviated while Mst1 overexpression aggravated cardiac dysfunction in diabetes. PMID: 27510910
10. these findings highlight a role for MST1 in vesicle trafficking and extravasation in neutrophils, providing an additional mechanistic explanation for the severe immune defect PMID: 27701149
11. Results identify L-plastin as a key effector of Mst1 and establish a novel mechanism linking a signaling intermediate to an actin-binding protein critical to T cell migration. PMID: 27465533
12. MIST1 is a scaling factor necessary and sufficient by itself to induce and maintain secretory cell architecture PMID: 28174210
13. Mst1 deficiency diminishes atherosclerosis and stabilizes atherosclerotic plaques in ApoE(-/-) mice. Mst1 may participate in atherosclerosis progression through inhibition of macrophage autophagy and promotion of macrophage apoptosis. PMID: 27496379
14. These results suggest that melatonin alleviates postinfarction cardiac remodeling and dysfunction by upregulating autophagy, decreasing apoptosis, and modulating mitochondrial integrity and biogenesis. The attributed mechanism involved, at least in part, Mst1/Sirt1 signaling PMID: 27696525
15. TRAF2 functions as a key activator of MST1 in oxidative stress-induced intracellular signaling processes. PMID: 26698664
16. Mst1 regulates hepatic lipid metabolism by inhibiting Sirt1 ubiquitination in mice. PMID: 26903296
17. Mst1 enhances Foxp3 expression and Treg function at the post-translational level. PMID: 26538561
18. our study demonstrates the existence of a direct crosstalk between mTORC2 and MST1 that is critical for cardiac cell survival and growth. PMID: 25843706
19. Mst1 regulates Myosin IIa dynamics to organize high and low affinity LFA-1 to the anterior and posterior membrane during T cell migration. PMID: 25133611
20. protein and mRNA expression of the MST1 and LATS2 were decreased significantly as mouse age increased (p < 0.05), however, the mRNA expression of them increased significantly in 16 m compared with 5 m as well as the protein expression of LATS2. PMID: 25659841
21. first evidence for HGFL as a positive regulator of mammary gland ductal morphogenesis by controlling overall epithelial cell turnover, macrophage recruitment, and STAT3 activation in the developing mammary gland PMID: 25049204
22. Rab13 acts with Mst1 to regulate the spatial distribution of LFA-1 and the motility and trafficking of lymphocytes PMID: 25074980
23. report implicates Mst1 as a critical regulator of adaptive immune responses, Th1/Th2-dependent cytokine production, and as a potential therapeutic target for immune disorders PMID: 24852423
24. functional consequences of the macrophage stimulating protein 689C inflammatory bowel disease risk allele PMID: 24409221
25. results showed that Mst1/Mst2 are required for proper cardiac lineage cell development and teratoma formation. PMID: 24224013
26. Mst1 promoted cardiac dysfunction in mice subjected to myocardial infarction by inhibiting autophagy, associated with increased levels of Thr108-phosphorylated Beclin1. PMID: 24141421
27. MST1 was found to mediate SOD1(G93A)-induced activation of p38 mitogen-activated protein kinase and caspases as well as impairment of autophagy in spinal cord motoneurons of SOD1(G93A) mice. PMID: 23818595
28. Results suggest that Mst1 has a key role in regulating thymocyte self-antigen recognition in the medulla. PMID: 23033074
29. findings reveal a tumor suppressive function of Mst1 based on its ability to prevent chromosomal instability in lymphocytes PMID: 22926556
30. Mst1 and Mst2 kinases control Rho GTPase activation and the migratory responses of single positive thymocytes. PMID: 22412158
31. Both MST1 and Fas death domain-associated protein (Daxx) are key mediators of microglial cell death induced by the proinflammatory cytokine interferon (IFN)-gamma. PMID: 21572393
32. Inhibition of TLR4-induced IkappaB kinase activity by the RON receptor tyrosine kinase and its ligand, macrophage-stimulating protein. PMID: 21078906
33. tolerance to increased levels of intracellular ROS provided by the Mst1-FoxOs signaling pathway is crucial for the maintenance of naive T cell homeostasis in the periphery PMID: 19956688
34. show that Mst1 and Mst2 play redundant roles, and removal of both resulted in early lethality in mouse embryos. PMID: 20080598
35. show using a conditional allele of sav1, that an adaptor that potentiates mst1 and mst2 activity is likewise required to suppress growth in the mature liver and to prevent tumor formation. PMID: 20080689
36. Data show that Ron mRNA is expressed by nerve growth factor-dependent sensory and sympathetic neurons and that these neurons survive and grow with macrophage stimulating protein (MSP) at different stages of development. PMID: 12538524
37. Macrophage-stimulating protein may actively suppress cell-mediated immune responses through its ability to down-regulate IL-12 production and thus inhibit classical activation of macrophages. PMID: 14734766
38. RAPL and Mst1 localized to vesicular compartments and dynamically translocated with LFA-1 to the leading edge upon Rap1 activation. PMID: 16892067
39. MST1 and MST2 are activated in mitosis and catalyze the mitotic phosphorylation of MOBKL1A/MOBKL1B, which is sufficient to inhibit proliferation through actions at several points in the cell cycle. PMID: 18328708
40. Mst1/2-catalyzed MOBKL1A/B phosphorylation slows proliferation and is therefore a likely contributor to the anti-proliferative action of Mst1 in naive T cells PMID: 19073936
41. Mst1 is crucial in controlling lymphocyte chemotaxis and thymocyte emigration PMID: 19692642

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KEGG: mmu:15235

STRING: 10090.ENSMUSP00000035211

UniGene: Mm.8369