Recombinant Mouse Histone-arginine methyltransferase CARM1 (Carm1)

1. C9orf72 acts by promoting the lysosomal degradation of coactivator-associated arginine methyltransferase 1 (CARM1), which in turn regulates autophagy-lysosomal functions and lipid metabolism. PMID: 30366907
2. Study describes peptide-based transition state mimics that form stable complexes with CARM1 resulting in high-resolution co-crystal structures. The findings provide an exciting approach to understanding protein arginine methyltransferase (PRMT) substrate recognition and the regulation of arginine methylation. PMID: 28330993
3. CARM1 promotes EZH2-mediated silencing of EZH2/BAF155 target tumor suppressor genes by methylating BAF155. PMID: 29434212
4. AMPK deficiency results in nuclear CARM1 decrease mediated in part by SKP2, contributing to autophagy dysfunction in the aged heart. PMID: 28315332
5. Study identifies CARM1, which methylates histone H3 at arginine 26 (H3R26), as an upstream regulator of Sox21 expression. These results indicate that heterogeneity in gene expression patterns biases cell fate in the mouse embryo as early as the 4-cell stage. PMID: 27015307
6. CARM1 haploinsufficiency impairs transdifferentiation and wound healing in a mouse model. PMID: 25906418
7. PRMT4 might be a key regulator of high-glucose-induced insulin secretion from pancreatic beta cells via H3R17 methylation. PMID: 25917831
8. Data show that the methyltransferase CARM1 (coactivator-associated arginine methyltransferase 1; PRMT4) methylated Notch intracellular domain (NICD) at five conserved arginine residues. PMID: 25805888
9. Arginine methylation of Pax7 by Carm1 functions as a molecular switch controlling the epigenetic induction of Myf5 during satellite stem cell asymmetric division and entry into the myogenic program. PMID: 22863532
10. CARM1 is a key epigenetic regulator of hematopoiesis that affects multiple lineages at various stages of differentiation. PMID: 23248263
11. our study provides evidence for a role of CARM1-mediated arginine methylation in regulation of histone acetylation and transcription. PMID: 22723830
12. PRMT4 is necessary for selective control of a specific gene expression program associated with glycogen metabolism. PMID: 22428544
13. Substantial quantities of soluble full-length mouse CARM1 were purified from transiently transfected HEK293T cells. PMID: 21126607
14. The results demonstrate for the first time that CARM1 inhibits pulmonary cell proliferation and is required for proper differentiation of alveolar cells. PMID: 20530543
15. Histone H3 arginine methylation by CARM1 in ES cells allows epigenetic modulation of pluripotency. PMID: 19544422
16. CARM1 requires its enzymatic activity for all of its known cellular functions. PMID: 19897492
17. CARM1 plays a significant role in promoting the differentiation of early thymocyte progenitors, possibly through its direct action on TARPP. PMID: 15096520
18. results show that CARM1/PRMT4 is a novel transcriptional coactivator of NF-kappaB and functions as a promoter-specific regulator of NF-kappaB recruitment to chromatin PMID: 15616592
19. p/CIP/SRC-3 activity and stability are regulated by CARM1-dependent methylation PMID: 17043108
20. The identification of splicing factors that are methylated by CARM1, and protein-protein interactions that are regulated by CARM1, strongly implicates this enzyme in the regulation of alternative splicing. PMID: 17218272
21. phosphorylation of CARM1 serves as a unique mechanism for inactivating CARM1-regulated estrogen-dependent gene expression PMID: 17640894
22. biochemical analysis of CARM1 methyltransferase and the histone code PMID: 17882261
23. the N-terminal and the C-terminal end of CARM1 catalytic module contain molecular switches that may determine how CARM1 regulates its biological activities by protein-protein interactions PMID: 17882262
24. These results show that CARM1 promotes adipocyte differentiation by coactivating PPARgamma-mediated transcription and thus might be important in energy balance. PMID: 18188184
25. study reveals thaat c-Fos-mediated transcriptional activation is regulated by CARM1 & by all 3 members of the p160 protein family of coactivators PMID: 18511550
26. MYPT1 and CARM1 are substrates of OGT and function to alter OGT substrate specificity in vitro PMID: 18840611
27. genetic complementation of carm1-/- cells with wild-type CARM1 or an enzymatic inactive mutant of CARM1 to investigate the requirement of CARM1 and its enzymatic activity for nuclear factor kappaB (NF-kappaB)-dependent gene expression PMID: 19769987
28. phosphorylation at Ser(217) serves as a molecular switch for controlling CARM1 enzymatic activity during the cell cycle. PMID: 19843527

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KEGG: mmu:59035

STRING: 10090.ENSMUSP00000034703

UniGene: Mm.178115