Recombinant Mouse Homeobox protein Nkx-2.1 (Nkx2-1)

1. Nkx2.1 regulates astrogliogenesis of the telencephalon from embryonic day (E) 14.5 to E16.5. Nkx2.1 controls astroglial production spatiotemporally in embryos by regulating proliferation of the contributing Nkx2.1-positive precursors. PMID: 28266561
2. NKX2-1 is required in the embryonic septum for cholinergic system development, learning, and memory. PMID: 28813670
3. Our findings demonstrate that NKX2-1 overexpression converts AFE to thyroid epithelium in a developmental time-sensitive manner and suggest a general methodology for manipulation of cell-fate decisions of developmental intermediates. PMID: 28162994
4. NKX2-1 binding at distal regulatory elements led to a repressed epigenetic state and transcriptional repression in the ventricular zone. Conversely, NKX2-1 is required to establish a permissive chromatin state and transcriptional activation in the sub-ventricular and mantle zones. PMID: 27657450
5. Study shows that within the NANCI-Nkx2.1 duplex, NANCI plays an essential role in regulating tissue identity by acting as a transcriptional rheostat to buffer Nkx2.1 expression. During lung development and in adult lung homeostasis, NANCI acts in cis to positively regulate Nkx2.1, and, in turn, Nkx2.1 directly inhibits NANCI expression. PMID: 28546511
6. data indicate that TTF-1 interacts with PPFP to inhibit the pro-adipogenic response to pioglitazone, and that the ability of pioglitazone to decrease TTF-1 expression contributes to its pro-adipogenic action. PMID: 27435678
7. Identify regulatory link between Nkx2-1, miR-200c, and the transcription factors Nfib and Myb, adding new players to the regulatory mechanisms driven by Nkx2-1 in lung epithelial cells that may have implications in lung development and tumorigenesis. PMID: 25763778
8. A population of neural stem cells in the ventral region of the adult ventricular-subventricular zone expresses the transcription factor Nkx2.1 and is derived from Nkx2.1-expressing (Nkx2.1+) embryonic precursors. PMID: 26387477
9. Prototypic GPe neurons derive from the medial ganglionic eminence of the embryonic subpallium and express the transcription factor Nkx2-1. These neurons fire at high rates during alert rest, and encode movements through heterogeneous firing rate changes. PMID: 25843402
10. Molecular characterization of disseminated tumor cells indicates that downregulation of the transcription factor Nkx2-1 precedes lung adenocarcinoma dissemination. PMID: 24740995
11. The Nkx2-1-mediated pathway in the DMH and LH stimulates skeletal muscle function via the sympathetic nervous system and maintains youthful physiology, contributing to the delay in aging and life span extension. PMID: 24011076
12. MicroRNA-33a mediates the regulation of high mobility group AT-hook 2 gene (HMGA2) by thyroid transcription factor 1 (TTF-1/NKX2-1). PMID: 23625920
13. A review of recent findings with special attention given to the role of NKX2-1 in lung development and carcinogenesis. PMID: 23763999
14. Nkx2-1 is likely to maintain pulmonary identity by recruiting transcription factors Foxa1 and Foxa2 to lung-specific loci. PMID: 23523371
15. Mouse models of bronchopulmonary dysplasia showed reduced levels of TTF-1 and increased levels of vimentin. PMID: 22931601
16. Haploinsufficiency of Nkx2-1 in combination with oncogenic Kras(G12D) caused pulmonary tumors in mice that were phenotypically similar to human mucinous adenocarcinomas. PMID: 23143308
17. Grhl2 and Nkx2-1 bind to each other's promoter in vivo, forming a positive feedback regulatory loop. PMID: 22955271
18. Muc5b is a target gene of transcription factors (TTF-1, GATA-6) involved in lung differentiation programs during development and carcinogenesis. TTF-1 is a strong repressor of Muc5b. PMID: 21126317
19. These data demonstrate that alpha5 is specifically controlled in a temporal and spatial manner during pulmonary morphogenesis. PMID: 21143907
20. Expression levels of Nkx2-1 direct target genes identified in mouse development significantly correlate or anti-correlate to the levels of endogenous NKX2-1 in a dosage-dependent manner in multiple human lung tumor expression data sets. PMID: 22242187
21. Data show that continuous expression of the transcription factor Nkx2-1 is essential for the maturation and maintenance of cholinergic basal forebrain neurons in mice. PMID: 22098391
22. A protein signature for Titf1/Nk x2-1, a known lineage survival oncogene in lung cancer, was found in plasmas of mouse models of lung adenocarcinoma. PMID: 21907921
23. Reduced expression of NKX2-1 in heterozygous NKX2-1 +/- gene targeted mice increased mucous metaplasia in the small airways after pulmonary sensitization to ovalbumin. PMID: 21562130
24. pleiotropic functions of Nkx2-1 are not all due to the protein as a whole since some of them can be assigned to separate domains of the protein or to specific post-translational modifications PMID: 21345181
25. Nkx2-1 controls tumour differentiation and limits metastatic potential in vivo PMID: 21471965
26. Data show that the cystic UBB was present even in the Nkx2-1;p63 double-null mice. PMID: 20697379
27. Thyroid transcription factor 1 is known to be indispensable in normal lung development PMID: 20194817
28. Loss of Nkx2-1 function from the Shh-expressing domain eliminated most globus pallidus neurons, whereas most cortical and striatal interneurons continued to be generated, except for striatal cholinergic neurons. PMID: 20181579
29. The robust expression of Nkx2.1 by neurons points to a broad functional spectrum within the young and adult forebrain. PMID: 19766601
30. role of TTF-1 in pulmonary morphogenesis and function PMID: 11820807
31. haploinsufficiency of the TTF1 gene results in a predominantly neurological phenotype and secondary hyperthyrotropinemia PMID: 11854318
32. role in regulating WNT7b promoter PMID: 11914369
33. synergistic transactivation by C/EBPalpha and Nkx2.1 in the regulation of the CCSP gene PMID: 12161423
34. Midkine staining in the respiratory epithelial cells correlated with sites of expression of thyroid transcription factor (TTF) -1, a transcription factor regulating formation and gene expression in the lung parenchyma PMID: 12761850
35. The development of the mesencephalic dopamine neuron system in mice lacking Nkx2.1 was examined; abnormal crossing of ascending DA axons observed may be attributed to the elimination of chemorepulsive signals PMID: 12821380
36. Phosphorylation of this protein is required for peripheral lung morphogenesis, perinatal survival, and tissue-specific gene expression. PMID: 12829717
37. TTF1 expression is regulated developmentally by mechanical forces generated by contractile activity of the diaphragm muscle play and has a role in normal lung growth and development PMID: 12895031
38. Ttf1 haploinsufficiency causes a reduction in the expression of tshr(thyroid-Stimulating Hormone) and thyroglobulin, genes with TTF1 binding sites in their promoter regions PMID: 12907760
39. NFI family members interact with TTF-1 to regulate pulmonary type II cell function PMID: 14645514
40. TTF-1 interacts with TAZ and has a role in regulating expression of surfactant protein-C PMID: 14970209
41. NFAT and thyroid transcription factor-1 have roles in regulating transcription of the surfactant protein D gene PMID: 15173172
42. the prospective dorsal midgut endoderm, which predominantly gives rise to the intestinal tract, is competent to respond to FGFs by inducing NKX2.1 PMID: 15576401
43. alpha(7) is induced by the essential pulmonary transcription factor TTF-1 and suppressed by Egr-1 during pulmonary development PMID: 16033766
44. Combination of partial deficiencies in the Titf1 and Pax8 genes results in an overt thyroid dysgenesis phenotype that is absent in either of the singly deficient, heterozygous mice. PMID: 16150900
45. Plays a role in the survival of ultimobranchial body (UBB) cells, their dissemination into the thyroid diverticulum, and the formation of UBB-derived vesicular structure. PMID: 16342117
46. Data show that Hop is expressed in airway epithelium coincident with HDAC2, and acts downstream of Nkx2.1 and GATA6, to negatively regulate surfactant protein expression. PMID: 16510470
47. T/ebp/Nkx2.1 is required for maintenance of the normal architecture and function of differentiated thyroids. PMID: 16601074
48. TTF1 is required for the timing of female puberty and maintenance of adult reproductive function in wild-type mice. PMID: 17182767
49. contribution of Nkx2.1 lineages to neurons in the mature telencephalon PMID: 17990269
50. Ttf-1/Nkx2.1 up-regulates the in vivo transcription of nes. PMID: 18033672

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KEGG: mmu:21869

STRING: 10090.ENSMUSP00000001536

UniGene: Mm.89972