Recombinant Mouse Keratin, type II cytoskeletal 8 (Krt8)

1. The authors found that keratin 8 suppressed toll-like receptor-induced nuclear factor (NF)-kappaB activation and interacted with the adaptor tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6) to prevent its polyubiquitination. PMID: 27586056
2. K8/K18 interact with Notch1 and regulate Notch1 signalling activity during differentiation of the colonic epithelium. PMID: 28475172
3. Mitochondria in K8 wild-type beta cells and MIN6 insulinoma cells overexpressing K8 and 18 are more stationary compared with mitochondria in keratin-deficient cells PMID: 28666985
4. DRA mRNA levels were decreased by three- to fourfold and DRA protein was almost entirely lost in K8-/- cecum and proximal and distal colon compared with K8+/+. PMID: 27125276
5. Upregulation of IL-22 in combination with a complete loss of its negative regulator IL-22BP, and increased downstream STAT3-signaling in K8(-/-) and K8(-/-)Apc(Min/+) colonic epithelia confirmed that the IL-22 pathway, important in inflammation, proliferation and tissue regeneration PMID: 27234655
6. Krt8 deletion (Krt8(-/-)) in a mouse model of cystic fibrosis (F508del-Cftr mice) increased the levels of circulating markers of bone formation, corrected the expression of osteoblast phenotypic genes, promoted trabecular bone formation and improved bone mass and microarchitecture. Krt8 deletion corrected overactive NF-kappaB signaling & decreased Wnt-beta-catenin signaling induced by F508del-Cftr mutation in osteoblasts. PMID: 26769674
7. Autoantibodies to several antigens were identified in 81% of K8-null male mice 8 mo or older. Similar autoantibodies were detected in aging K18-null male mice that had a related liver phenotype but normal colon compared with K8-null mice PMID: 26399787
8. The regulation of the SCFA-MCT1-HMGCS2 axis is disrupted in K8(-/-) colonocytes, suggesting a role for keratins in colonocyte energy metabolism and homeostasis. PMID: 25904331
9. using knockout mice, we show K8+/- colon expresses ~50% less keratins compared to K8 wild type. In experimental colitis, K8+/- mice showed higher disease sensitivity and delayed recovery compared to K8+/+ littermates. PMID: 26000979
10. In several liver stress models epiplakin and K8 genes displayed identical expression patterns and transgenic K8 overexpression resulted in elevated hepatic epiplakin levels. PMID: 25617501
11. Directed expression of a chimeric type II keratin partially rescues keratin 5-null mice. PMID: 24867950
12. Our data demonstrate that HF diet triggers aggregate formation and development of liver injury in susceptible individuals through misfolding and crosslinking of excess K8. PMID: 24519272
13. K8 inactivation leads to reduced fasting blood glucose levels and resistance to hyperglycaemia after glucose challenge. PMID: 24144696
14. Keratin 8 is required for the maintenance of architectural structure in thymus epithelium. PMID: 24086449
15. A conserved rod domain phosphotyrosine that is targeted by the phosphatase PTP1B promotes keratin 8 protein insolubility and filament organization. PMID: 24003221
16. K8 acetylation at Lys-207, a highly conserved residue among type II keratins, is up-regulated upon hyperglycemia and down-regulated by SIRT2. PMID: 23358244
17. Data indicate that cyclin D1 is expressed exclusively in luminal keratin 8 immunoreactive tumor cells and is dependent on the adipose secreted hormone leptin. PMID: 22692856
18. Mice lacking the prostate epithelial AR have increased apoptosis in epithelial CK8-positive luminal cells and increased proliferation in epithelial CK5-positive basal cells. PMID: 21754978
19. Data show that lack of K8 confers resistance to colonocyte apoptosis in a microflora-dependent manner. PMID: 21220329
20. The expression of K8 is positively correlated with the liver injury induced by CCl(4). PMID: 20175234
21. Krt8 may be a useful immunohistochemical marker for detecting hepatocellular proliferative lesions in mice. PMID: 20035116
22. function of K8 as a plasminogen receptor PMID: 11689350
23. potentially toxic bile acids induce hepatocytic CK 8 and CK 18 expression and phosphorylation PMID: 11839569
24. K8 cytokeratin has a relevant role during the differentiation and tridimensional organization of the sensory and the supporting cells of the auditory receptor PMID: 12168793
25. distribution in cell clusters in mouse embryonic tongue as a marker for a prepattern for taste bud development PMID: 12541313
26. The role that UBB(+1) plays in cytokeratin aggresome formation in Mallory Bodies in vitro was studied. PMID: 12710947
27. lethality of Keratin 8-/- embryos is due to a TNF-sensitive failure of trophoblast giant cell barrier function PMID: 12771125
28. Results suggest that keratin 8 may play a role in regulating electrolyte transport, likely by targeting ion transporters to their cellular compartments. PMID: 15007064
29. K8 overexpression is sufficient to form pre-MB and primes animals to accumulate MBs upon DDC challenge, which may help explain MB formation in human liver diseases. PMID: 16365160

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KEGG: mmu:16691

STRING: 10090.ENSMUSP00000023952

UniGene: Mm.358618