Recombinant Mouse Killer cell lectin-like receptor subfamily B member 1C (Klrb1c), partial

1. The adoptive transfer of NK1.1(-) CD4(+) NKG2D(+) cells suppressed DSS-induced colitis largely dependent on TGF-beta. Thus, NK1.1(-) CD4(+) NKG2D(+) cells exhibited immune regulatory functions, and this T cell subset could be developed to suppress inflammation in clinics. PMID: 28224733
2. MCMV may encode a novel Clr-b-independent immunoevasin that functionally engages the NKR-P1B receptor. PMID: 26044139
3. NK1.1+ CD8+ T cells have a role in TGF-beta control and contribute to early microbial pathogen response PMID: 25284210
4. Data indicate that C-type lectin-like NK receptor NKR-P1C proteins showed no affinity to the various neoglycoproteins. PMID: 24076118
5. 5-HT3 and NK1 immunopositive macrophages and mucosal mast cells in lamina propria release 5-HT and substance P, which in turn activate their corresponding receptors on mucosal cells in autocrine and paracrine manners. PMID: 23695873
6. Nkrp1-Clr gene cluster appears to evolve more slowly relative to the related Ly49 cluster, and likely regulates innate immunosurveillance in a tissue-specific manner PMID: 23226525
7. NK1.1-positive cells contribute to BCG-induced protective immunity to Mycobacterium tuberculosis through interactions with T cells in a mouse model. PMID: 22711885
8. A functional dimeric form of the receptor is suggested, with the loop, evolutionarily conserved within this family, proposed to participate in interactions with ligands. PMID: 21600988
9. CD11c-positive cells in the thyroid of CCL21 transgenic mice express the natural killer cell marker NK1.1, indicating their NK origin. PMID: 21666055
10. results identify the minimal upstream cis-acting elements, and point to a complex regulatory mechanism involved in the lineage-specific control of NKR-P1C expression in NK lymphocytes PMID: 12813047
11. Engagement of NKR-P1C stimulates cytotoxicity of target cells, Ca2+ flux, phosphatidylinositol turnover, kinase activity, and cytokine production. In contrast, NKR-P1B engagement inhibits NK cell cytotoxicity. PMID: 15814704
12. Lactobacilli selectively activate CD1d-independent NK1.1+ T cells in the large intestine to produce IFN-gamma and therefore modulate Th1 immune responses PMID: 16107279
13. Allelic divergence of Nkrp1b/c gene products explains a longstanding confusion regarding the strain-specific NK1.1 alloantigen reactivity of mouse natural killer cells. PMID: 16751398
14. In a natural killer cell subset NK1.1(+) cells depended primarily on interleukin 15 and common cytokine receptor gamma chain signaling for their development. PMID: 17923504
15. Thus, we present first evidence that NK1.1 surface expression on liver iNKT cells is reversible during L. monocytogenes infection, and that different mechanisms underlie stimulation by TCR and IL-12. PMID: 18024119
16. Bone marrow transplant rejection in congenic mice is regulated by haplotypes of the natural killer (NK) gene complex that encodes multiple NK cell receptors. PMID: 18292550
17. Lactobacillus pentosus strain S-PT84 effectively promoted type 1 immunity through IL-12 and IFN-gamma which were produced by DCs and NK1.1(+) cells. PMID: 18620001

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KEGG: mmu:17059

STRING: 10090.ENSMUSP00000134504

UniGene: Mm.480764