Recombinant Mouse LIM domain transcription factor LMO4 (Lmo4)

1. Multiple roles of Lmo4 during retinal development. PMID: 26579872
2. These results reveal a novel, LMO4-dependent transcriptional program within the basolateral amygdala that is essential to cue-reward learning. PMID: 26134647
3. activation of SLK by haptotactic signals requires its recruitment to the leading edge by LMO4 in a Src-dependent manner. PMID: 25882817
4. Thus, our study reveals an essential requirement for LMO4 to modulate central insulin signaling. PMID: 24937445
5. A novel sensory competent region in the lateral cochlear duct is regulated by LMO4. PMID: 25057208
6. By increasing neuronal activity in the paraventricular hypothalamus, food intake was suppressed in LMO4-deficient mice. PMID: 24381275
7. LMO4 is a novel modulator of adipogenesis. PMID: 23892074
8. The results of this study found that LIM domain only 4 (LMO4) inhibits PTP1B activity by increasing the oxidized inactive form of PTP1B in hypothalamus of mice. PMID: 23904601
9. results identify Lmo4 as a central developmental control over the diversity of motor cortex projection neuron subpopulations, establishing their area-specific identity and specialized connectivity. PMID: 23575831
10. LMO4 modulates the activity of the DEAF NES, causing nuclear accumulation of a construct containing the LMO4-interaction region of DEAF1. PMID: 22723967
11. a selective role for LMO4 in the basolateral complex in modulating learned but not unlearned fear PMID: 22509321
12. This study demonitratd that LMO4 as a key regulator of calcium-induced calcium release in central neurons, providing a mechanism for LMO4 to modulate a wide range of neuronal functions and behavior. PMID: 22442089
13. LMO4 is expressed in the ventromedial hypothalamic nuclei but not in the arcurate nucleus, and consistent with their predominant effects in regulating fate metabolism/energy expenditure and feeding. PMID: 21874351
14. LMO4 and estrogen receptor alpha are associated with the Alk promoter by chromatin immunoprecipitation and Alk is an estrogen-responsive gene in the striatum. PMID: 21976498
15. Results indicate that LMO4 promotes the acquisition of cortical neuronal identities by forming a complex with NGN2 and subsequently activating NGN2-dependent gene expression. PMID: 21652654
16. Our finding of an essential postnatal function of LMO4 in the differentiation of Bhlhb5-expressing inhibitory interneurons in the retina may be a general mechanism whereby LMO4 controls the production of inhibitory interneurons in the nervous system PMID: 20949055
17. Data indicated that there is a genetic interaction between Cited2 and Lmo4 in control of thymus development. PMID: 20549734
18. The LMO4 enhances GCSF-induced Stat3 signaling in neurons, in part by sequestering histone deacetylase. PMID: 19997957
19. Lmo4 controls the development of the dorsolateral otocyst into semicircular canals and cristae through two distinct mechanisms. PMID: 19913004
20. Expression of Lmo4 in a fusion protein in mammary epithelial cells inhibits mammary gland development in mice. PMID: 14676840
21. Results suggest that all four members of the LIM-only family -- LMO1, 2, 3, and 4 -- are important regulators of distinct developmental pathways. PMID: 14966285
22. Data indicate an important role for LMO4 and Deaf-1 in pathways affecting neural tube closure and skeletal patterning, most likely reflecting their presence in a functional complex in vivo. PMID: 14966286
23. LMO4 is essential for proliferation and survival of neural epithelial cells in the rostral neural tube. LMO4 is also expressed in Schwann cell progenitors after these contact neurites, a process mediated in part by neuregulin (Nrg). PMID: 15691703
24. the expression profile of Lmo4 suggests that this cofactor is an important regulator of epithelial proliferation PMID: 15805422
25. Lmo4 acts as a positive regulator of alveolar epithelial proliferation PMID: 15856027
26. LMO4 was confined to the dental epithelium and had spatial temporal expression patterns during tooth morphogenesis. PMID: 16255927
27. These observations identify LMO4 as a calcium-dependent transactivator that plays a key role in patterning thalamocortical connections during development. PMID: 16899735
28. These findings indicate that the Get-1 and LMO4 genes interact functionally to regulate epidermal terminal differentiation. PMID: 16949565
29. Thus, our results suggest that ATP modulates recruitment of RNA-binding proteins to the 3'UTR to stabilize LMO4 mRNA. PMID: 17418808
30. Data reveal that LMO4 is a rapidly induced downstream effector of ATP signaling that promotes neuron survival from hypoxia. PMID: 17524392
31. Study demonstrates that the LIM-only domain protein, LMO4 serves as a functional partner of GRHL3 in its established roles, and define a new cooperative role for these factors in another developmental epidermal migration event, eyelid fusion. PMID: 18619436
32. LMO4 plays essential roles in directing a balanced generation of inhibitory and excitatory neurons in the ventral spinal cord. PMID: 19323994
33. The LIM-homeodomain-related genes Lmo4 and Clim1 are initially expressed by both CPN and subcerebral PN in layer V, and only during mid to late differentiation does expression of Lmo4 and Clim1 become largely segregated into distinct neuronal subtypes. PMID: 19366868

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KEGG: mmu:16911

STRING: 10090.ENSMUSP00000113513

UniGene: Mm.29187