Recombinant Mouse Lymphatic vessel endothelial hyaluronic acid receptor 1 (Lyve1), partial

1. Study in metastatic MDA-MB-231 xenograft models shows that LYVE-1 is involved in primary tumor formation and metastasis, and it may be a promising molecular target for cancer therapy. PMID: 30058195
2. lymphatic vessel endothelial hyaluronan receptor-1 (LYVE1) is identified as a marker of yolk sac (YS) endothelium and definitive hematopoietic stem and progenitor cells. PMID: 27880904
3. Dendritic cells (DCs) docked to the basolateral surface of lymphatic vessels and transited to the lumen through hyaluronan-mediated interactions with the lymph-specific endothelial receptor LYVE-1. Targeted deletion of the gene Lyve1, antibody blockade or depletion of the DC hyaluronan coat not only delayed lymphatic trafficking of dermal DCs but also blunted their capacity to prime CD8(+) T cell responses in LNs. PMID: 28504698
4. the LYVE-1-expressing cells might be involved in the uptake of hyaluronan and other waste products as well as foreign particles circulating in the blood and lymph while participating in the subsequent degradation in relay with adjacent macrophage populations. PMID: 27356606
5. Immunostaining analyses in VEGF-A transgenic skin suggested that the ectodomain shedding of LYVE-1 occurred in lymphatic vessels undergoing chronic inflammation. These results indicate that the ectodomain shedding of LYVE-1 might be involved in promoting pathological lymphangiogenesis. PMID: 26966180
6. Endogenous hyaluronan on the surface of macrophages can engage LYVE-1, facilitating their adhesion and transit across lymphatic endothelium. PMID: 26823460
7. MT1-MMP directly cleaves LYVE-1 on lymphatic endothelial cells to inhibit LYVE-1-mediated lymphangiogenic responses and restrains the production of VEGF-C. PMID: 26926389
8. Data (including data from studies in knockout mice) suggest Lyve1 mediates adhesion of group A Streptococci (GAS) to lymphatic vesicular endothelium via capsular hyaluronan; this appears to be critical factor for lymphatic trafficking of GAS in vivo. PMID: 26352587
9. Data show that the expression of lymphatic vessel endothelial hyaluronan receptor 1 (LYVE 1) was similar with vascular endothelial growth factor C (VEGF-C), but its peak appeared 1-2 d later than that of VEGF-C. PMID: 25270205
10. LMW-HA may play a critical role in the processes required for lymphangiogenesis through interactions with its receptor LYVE-1 and triggering intracellular signal cascades. PMID: 24667755
11. Studied the specific targeting property of lymphatic vessel endothelial hyaluronan receptor-1 binding polyethylene glycol-coated ultrasmall superparamagnetic iron oxide (LYVE-1-PEG-USPIO) nanoparticles to mouse lymphatic endothelial cells. PMID: 23818783
12. Reelin-deficient mice showed abnormal collecting lymphatic vessels, characterized by a reduced number of SMCs, abnormal expression of lymphatic capillary marker lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1), and impaired function PMID: 22665518
13. report intact CD31(+) corneal lymphatic capillary endothelial cells that do not express LYVE-1. The number of LYVE-1(-) gaps initially increased until 8 wk of age but was significantly reduced in aged mice. PMID: 22090317
14. Adrenomedullin and SB431542 enhance the induction of LYVE-1-positive endothelial cells during late phase differentiation. PMID: 21782867
15. CRSBP-1 ligands induce disruption of VE-cadherin-mediated intercellular adhesion and opening of intercellular junctions in lymphatic endothelial cell. PMID: 21444752
16. Expression of lymphatic endothelium-specific hyaluronan receptor LYVE-1 in the developing mouse kidney PMID: 21181199
17. the expression of lymphatic vessel endothelial hyaluronan receptor-1 is dramatically reduced early in Lama2-deficient muscle pathogenesis PMID: 20876525
18. This study provides the first evidence that the hyaloid vascular system contains a LYVE-1(+) cellular component in both physiological and pathologic conditions. PMID: 20688736
19. LYVE-1 is not exclusive to the lymph vessels PMID: 11719431
20. Lymphatic endothelial cells in the intestine of T1a/podoplanin -/- mice had high levels of Lyve-1 protein in the luminal and abluminal plasma membranes. PMID: 12853470
21. Ang signaling regulates LYVE-1-positive lymphatic vessel formation through Tie2 PMID: 15705793
22. The CRSBP-1 ligands PDGF-BB and HA enhance interstitial-lymphatic flow in wild-type mice but not in CRSBP-1-null animals PMID: 17070806
23. LYVE-1 is not obligatory for normal lymphatic development and function and suggest either the existence of compensatory receptors or a role more specific than that previously envisaged. PMID: 17101772
24. The occurrence of LYVE-1-expressing lymphatic compartments and the alteration of CCL21 expression in the lymphatics may be involved in defective thymocyte differentiation and migration, and play a significant role in insulitic and diabetic processes. PMID: 17176958
25. The recruitment, infiltration and accumulation of bone marrow-derived LYVE-1-expressing macrophages are crucial for the formation of the dense vascular network in adipose tissue. PMID: 17272806
26. describe the development of hepatic sinusoids in mice based on the expression of hyaluronan receptors Stab2 and Lyve-1 PMID: 17626278
27. analysis of inflammation-induced uptake and degradation of the lymphatic endothelial hyaluronan receptor LYVE-1 PMID: 17884820
28. Data show that LYVE-1 is expressed on blood vessels of the yolk sac during embryogenesis, on intra-embryonic arterial and venous endothelium at early embryonic stages, and on endothelial cells of the lung and endocardium throughout embryogenesis. PMID: 18570254
29. Our findings support an important role of CD44 expressed by CD4(+) and CD8(+) for development of ileitis mediated by TNF overproduction. PMID: 18854186
30. complexity in the regulation of LYVE-1 function and raise the possibility that this receptor, like CD44, may become active after appropriate unmasking in vivo. PMID: 19033446
31. These data suggest that LYVE-1 and CD44 are not required for the formation or function of lymphatics, but do not rule out a role for LYVE-1 in inflammation. PMID: 19170073
32. Immunostaining for the specific lymphatic markers LYVE-1 revealed an extensive lymphatic vessel system in dental tissues. Unexpected cell staining for the above lymphatic markers was found in the pulp of both molars and incisors in mice. PMID: 19196316

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KEGG: mmu:114332

STRING: 10090.ENSMUSP00000033050

UniGene: Mm.396078