Recombinant Mouse Mesoderm posterior protein 1 (Mesp1)

1. This approach enabled discovery of subpopulations primed for hematopoietic or cardiac development. These studies demonstrate the heterogeneic nature of Mesp1+ mesoderm. PMID: 27131741
2. YY1 and SP1 independently and cooperatively govern the Mesp1 expression during embryogenesis. PMID: 26384464
3. Data indicate an embryonic stem cell-based system in which mesoderm posterior 1 protein (MESP1) drives a PDGF alpha Receptor (PDGFRA+) population with dual cardiac and skeletal muscle differentiation potential. PMID: 26771351
4. data indicate that the myocardial layer of the heart derive from approximately 250 Mesp1-expressing cardiac progenitors born during gastrulation. PMID: 26725109
5. MESP1, a pioneer cardiac factor, directs the appearance of mesendoderm, the intermediary of the earliest progenitors of mesoderm and endoderm organogenesis. PMID: 26205879
6. Studies indicate that mesodermal posterior 1 (Mesp1) and mesodermal posterior 2 (Mesp2) double-knockout embryos exhibited defective development of the embryonic mesoderm. PMID: 26088191
7. Data indicate that transcription factor Mesp1 interacts physically with cAMP-responsive element binding protein 1 (Creb1) and transcriptionally regulates Ets variant 2 (Etv2) gene expression. PMID: 25694434
8. Embryonic heart development arises from distinct populations of unipotent and bipotent cardiac progenitors that independently express Mesp1 at different time points during their specification. PMID: 25150979
9. This Tcf/Lef-Oct4 composite site mediated synergistic activation of the Mesp1 promoter by Oct4 and canonical Wnt signaling. PMID: 23417899
10. Mesp1 is a context-dependent determination factor, integrating the stage of differentiation and the signaling environment to specify different lineage outcomes. PMID: 23642367
11. These results place Eomes upstream of the Mesp1-dependent programme of cardiogenesis, and at the intersection of mesodermal and endodermal specification, depending on the levels of Activin/Nodal signalling. PMID: 22402664
12. shRNA-based loss of Brachyury(T) causes a dramatic decrease in MesP1 expression accompanied by reduced cardiac markers in differentiating embryonic stem cells PMID: 21632880
13. Data show that Eomes promotes formation of cardiovascular progenitors by directly activating the bHLH transcription factor gene Mesp1 upstream of the core cardiac transcriptional machinery. PMID: 21822279
14. Mesp1 is required to promote the specification of multipotent cardiovascular progenitors (MCPs)and the expression of cardiovascular transcription factors in MCPs. PMID: 21383076
15. approximately 20% of the ventricular cardiac conduction system within the IVS corresponds to Mesp1-nonexpressing cells PMID: 16317723
16. Mesp1 is down-regulated in the later stages of development by increasing levels of Mesp2 in the wild-type embryo. PMID: 16996494
17. appropriate suppression of Notch signaling by Mesp1 and Mesp2 factors is essential for stripe pattern formation leading to segment boundary formation PMID: 17306789
18. MesP1 drives vertebrate cardiovascular differentiation through Dkk-1-mediated blockade of Wnt-signalling PMID: 18297060
19. analysis of the roles of Mesp1 and Mesp2 through knockout mouse models PMID: 18328678
20. Embryonic stem cells are used to identify a key role for Mesp1 for stem-based cardiac regeneration. PMID: 18593549
21. Mesp1 may be capable of generating the recently identified multipotent cardiovascular progenitor from embryonic stem cells in vitro. PMID: 18593559
22. Mesp1 acts as a key regulatory switch during cardiovascular specification, residing at the top of the hierarchy of the gene network responsible for cardiovascular cell-fate determination PMID: 18593560
23. Report forward programming of pluripotent stem cells towards distinct cardiovascular cell types via Nkx2.5 and MesP1 pathways. PMID: 19564151

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KEGG: mmu:17292

STRING: 10090.ENSMUSP00000032760

UniGene: Mm.1404