Product Details

Purity

>85% (SDS-PAGE)

Target Names

Mta1

Uniprot No.

Q8K4B0

Alternative Names

Mta1; Metastasis-associated protein MTA1

Species

Mus musculus (Mouse)

Expression Region

1-715

Target Protein Sequence

MAANMYRVGD YVYFENSSSN PYLIRRIEEL NKTANGNVEA KVVCFYRRRD ISSSLIALAD KHATLSVCYR AGPGADTGEE GEVEEEVENP EMVDLPEKLK HQLRHRELFL SRQLESLPAT HIRGKCSVTL LNETESLKSY LEREDFFFYS LVYDPQQKTL LADKGEIRVG NRYQADITDL LKEGEEDGRD QSKLETKVWE AHNPLVDKQI DQFLVVARSV GTFARALDCS SSVRQPSLHM SAAAASRDIT LFHAMDTLHK NIYDISKAIS ALVPQGGPVL CRDEMEEWSA SEANLFEEAL EKYGKDFTDI QQDFLPWKSL TSIIEYYYMW KTTDRYVQQK RLKAAEAESK LKQVYIPNYN KPNPNQISAS SVKATVVNGT GTPGQSPGAG RACESCYTTQ SYQWYSWGPP NMQCRLCASC WTYWKKYGGL KMPTRLDGER PGPNRNNMSP HGIPARSSGS PKFAMKTRQA FYLHTTKLTR IARRLCREIL RPWHAARHPY MPINSAAIKA ECTARLPEAS QSPLVLKQVV RKPLEAVLRY LETHPRPPKP DPVKSSSSVL SSLTPAKSAP VINNGSPTIL GKRSYEQHNG VDGNMKKRLL MPSRGLANHG QTRHMGPSRN LLLNGKSYPT KVRLIRGGSL PPVKRRRMNW IDAPDDVFYM ATEETRKIRK LLSSSETKRA ARRPYKPIAL RQSQALPLRP PPPAPVNDEP IVIED

Protein Length

full length protein

Tag Info

Tag type will be determined during the manufacturing process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer before Lyophilization

Tris/PBS-based buffer, 6% Trehalose, pH 8.0

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet

Please contact us to get it.

Target Background

Function

Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator. As a part of the histone-deacetylase multiprotein complex (NuRD), regulates transcription of its targets by modifying the acetylation status of the target chromatin and cofactor accessibility to the target DNA. In conjunction with other components of NuRD, acts as a transcriptional corepressor of BRCA1, ESR1, TFF1 and CDKN1A. Acts as a transcriptional coactivator of BCAS3, PAX5 and SUMO2, independent of the NuRD complex. Stimulates the expression of WNT1 by inhibiting the expression of its transcriptional corepressor SIX3. Regulates p53-dependent and -independent DNA repair processes following genotoxic stress. Regulates the stability and function of p53/TP53 by inhibiting its ubiquitination by COP1 and MDM2 thereby regulating the p53-dependent DNA repair. Plays an important role in tumorigenesis, tumor invasion, and metastasis. Plays a role in the regulation of the circadian clock and is essential for the generation and maintenance of circadian rhythms under constant light and for normal entrainment of behavior to light-dark (LD) cycles. Positively regulates the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of its own transcription and the transcription of CRY1. Regulates deacetylation of ARNTL/BMAL1 by regulating SIRT1 expression, resulting in derepressing CRY1-mediated transcription repression. With Tfcp2l1, promotes establishment and maintenance of pluripotency in embryonic stem cells (ESCs) and inhibits endoderm differentiation.

Gene References into Functions

MTA1 participates in the formation of pulmonary capillaries via stabilization of HIF-1alpha. This finding sheds new light on the function of MTA1 in lung development. PMID: 28808223
Findings illustrate how cancer cells utilize a chromatin remodeling factor to engage a core survival pathway to support its cancerous phenotypes, and reveal new facets of MTA1-SGK1 axis by a physiologic signal in cancer progression. PMID: 28504714
the augmentation of endogenous MTA1 expression during neuronal ischemic injury acts additionally to an endocrinous cascade orchestrating intimate interactions between ERalpha and BCL2 pathways. PMID: 26728277
Findings highlight MTA1 as a key upstream regulator of prostate tumorigenesis and cancer progression. PMID: 26943043
Inhibition of MTA1 expression by in vivo siRNA treatment exacerbated the pathology of LPS-induced acute lung injury, by selectively promoting the expression of NF-kappaB-regulated inflammatory cytokines. PMID: 26891867
MTA1 was regulated by HIF-1alpha in hypoxia circumstance to suppress osteoblast differentiation. PMID: 25644400
MTA1 levels were increased in monosodium urate crystal-induced inflammation. PMID: 25889736
The inhibition of MTA1 gene could depress the growth and metastasis of laryngeal squamous cell carcinoma in nude mice. PMID: 26359099
Data suggest that nuclear metastasis-associated protein 1 (MTA1) is a good marker for cancer differentiation diagnosis and a potential target for the treatment of cancers. PMID: 24970816
this study reports the potential signaling events related to up-regulation of metastasis associated protein 1 (Mta1), a master chromatin modifier, during mono-(2-ethylhexyl) phthalate (MEHP)-induced Sertoli cells injury. PMID: 25153068
MTA1 has an important role in the maintenance of circadian rhythmicity. PMID: 24089055
the MTA1/NFkappaB/FasL circuit may serve as an important defensive/repairing mechanism to help to control the germ cell quality after Sertoli cell injury. PMID: 24120950
MTA1 is a major contributor to prostate tumor malignant progression. PMID: 23469203
Data indicate that metastasis tumor antigen 1 (MTA1)-dependent stimulation of STAT3 transcription through action on the MTA1/STAT3/Pol II coactivator complex. PMID: 23580571
The changes of the expression sites and quantity of MTA1 in the DEN-induced carcinogenesis of mouse liver indicate that MTA1 may play an important role in the whole process of liver carcinogenesis. PMID: 22863583
Metastasis-associated protein 1/histone deacetylase 4-nucleosome remodeling and deacetylase complex regulates phosphatase and tensin homolog gene expression and function. PMID: 22700976
The fine coordination between MTA1 and p53 in pachytene spermatocytes upon hyperthermal stimulation, was investigated. PMID: 22022494
findings suggest that MTA1 status plays an important role in conferring an optimal cytokine response in mice following infection with Opisthorchis viverrini and is a major player in parasite-induced cholangiocarcinoma in humans PMID: 21725997
The metastasis-associated protein-1 gene encodes a host permissive factor for schistosomiasis, a leading global cause of inflammation and cancer. PMID: 21488078
Gene profiling of MTA1 identifies novel gene targets and functions. PMID: 21364872
findings reveal an obligatory coregulatory role of MTA1 in the regulation of TG2 expression and of the MTA1-TG2 pathway, at least in part, in LPS modulation of the NF-kappaB signaling in stimulated macrophages PMID: 21156794
Data suggest that the expression of MTA1 protein could be regulated by androgen pathway and closely associated with the postnatal development of the epididymis, and that this gene may play a potential role in sperm maturation and fertility. PMID: 21082030
MTA1 regulation of MyD88 may constitute at least one of the mechanisms by which MTA1 stimulates LPS-induced NF-kappaB signaling in stimulated macrophages. PMID: 20702415
there is a p53-independent function of MTA1 in DNA damage response via modulation of the p21 WAF1-proliferating cell nuclear antigen pathway PMID: 20071335
Results suggest an inherent role of the MTA1-p53-p53R2 pathway in DNA damage response in cancer cells. PMID: 19837670
In mature mice, MTA1 expression was seen in cell types that constantly undergo proliferation or self-renewal, such as testis and cell types not constantly engaged in proliferation or self-renewal, such as brain, liver and kidney PMID: 19524276
Assignment of the metastasis-associated gene (Mta1) to mouse chromosome band 12F and the metastasis-associated gene 2 (Mta2) to mouse chromosome band 19B by fluorescence in situ hybridization PMID: 11856890
Mta1 interacts with endophilin 3, the site of interaction is suggested to be the SH-3-binding domain of Mta1 and SH-3 domain of endophilin 3. PMID: 15978591
The cDNAs of the splicing variants were inserted into green fluorescent protein (GFP) expression vector and the subcellular localization of the GFP-Mta1 fusion proteins were analyzed. PMID: 16445996
structure and antiestrogenic activity of the unique C-terminal, NR-box motif-containing region of MTA1 PMID: 16807247
Mta1 appears during postnatal testis development and this expression may be crucial for spermatogenesis. PMID: 17401724
role for the MTA1 as an upstream modifier of Six3 and indicate that Six3 is a direct stimulator of rhodopsin expression. PMID: 17666527
These results demonstrate the importance of FOG-2/MTA/RbAp interactions for FOG-2-mediated transcriptional repression and further define the molecular interactions between the FOG repression motif and the NuRD complex. PMID: 18067919
Mta1 may operate as a negative modifier of apoptosis by interacting with p53 during gametogenesis. PMID: 18282480
Data describe the expression of metastasis associated protein 1 (MTA1) in the brain of aging mice and its interaction with the estrogen receptor alpha transactivation domain. PMID: 18679832
This study was undertaken to explore the potential role of MTA1 in mouse liver. PMID: 18769059
MTA1 is required for optimum DNA double-strand break repair after ionizing radiation. PMID: 19805145

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Subcellular Location

Nucleus. Nucleus envelope. Cytoplasm. Cytoplasm, cytoskeleton. Note=Associated with microtubules. Primarily localized in the cytoplasm in embryonic tissues. Localization at the nuclear envelope is TPR-dependent.

Tissue Specificity

Widely expressed but not in skeletal muscle. Highly expressed in the brain, liver, kidney and cardiac muscle and in mammary tumors.

Database Links

STRING: 10090.ENSMUSP00000105348

UniGene: Mm.212577

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Code	CSB-YP817005MO
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Code	CSB-MP817005MO
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Recombinant Mouse Metastasis-associated protein MTA1 (Mta1)

Product Details

Customer Reviews and Q&A

Target Background

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