Recombinant Mouse Microtubule-associated proteins 1A/1B light chain 3A (Map1lc3a)

1. During the liver stage of a malaria infection, plasmodium UIS3 binds host microtubule-associated protein 1 light chain 3 (LC3) through a non-canonical interaction with a specialized surface on LC3 where host proteins with essential functions during autophagy also bind. UIS3 acts as a autophagy inhibitor by competing with host LC3-interacting proteins for LC3 binding. PMID: 29109477
2. The LC3-decorated vacuoles are bound by an apparently undamaged single membrane, and fail to associate with the molecules implicated in selective autophagy, such as ubiquitin or adaptors. PMID: 28317932
3. With increasing age, expression of the autophagy proteins ATG5 and LC3 in meniscus and articular cartilage was significantly reduced by 24 months. PMID: 28801209
4. the conjugation of ubiquitin-like LC3 homologs to the phospholipids of membranes may change the destiny of the membranes beyond degradation through lysosomal fusion PMID: 27172324
5. analysis of soluble SQSTM1 complexes and soluble complexes formed between SQSTM1 oligomers and LC3 using a combination of fluorescence microscopy-based biophysical approaches in living cells PMID: 27442348
6. paxillin interacts with processed LC3 through a conserved LIR motif in the amino-terminal end of paxillin and that this interaction is regulated by oncogenic SRC activity. PMID: 27184837
7. These results suggest that the Golgi complex may serve as a membrane platform for noncanonical autophagy where V-ATPase is a key player. PMID: 27512951
8. LC3 was down regulated in the hypothalamus of diabetic mice. PMID: 28456145
9. LC3 overexpression in 3T3-L1 preadipocytes stimulates adipocyte differentiation via direct modulation of RKIP-dependent ERK1 activity. PMID: 27470585
10. These findings demonstrate that LC3 contributes to melanogenesis by increasing ERK-dependent MITF expression, thereby providing a mechanistic insight into the signaling network that links autophagy to melanogenesis. PMID: 26814135
11. LC3 is exploited by coxsackievirus in both autophagy-dependent and -independent manners in vivo PMID: 26090585
12. LC3 overexpression thus exerts neuroprotection through increasing alpha7nAChR expression for eAbeta binding and further enhancing autophagic activity for Abeta clearance in vitro and in vivo. PMID: 25686800
13. we describe basic protocols to measure the levels of endogenous LC3 and p62 by immunoblotting in cultured mammalian cells PMID: 25484342
14. Clusterin facilitates stress-induced lipidation of LC3 and autophagosome biogenesis to enhance cancer cell survival. PMID: 25503391
15. Data indicate that Rubicon (Kiaa0226) and NOX2 (gp91phox) are involved in microtubule-associated protein LC3-associated phagocytosis. PMID: 26098576
16. starvation activates the autophagic PI3K, which in turn induces the recruitment of COPII to the endoplasmic reticulum-Golgi intermediate compartment to bud LC3 lipidation-active vesicles as one potential membrane source of the autophagosome. PMID: 25432021
17. With increasing age, the expression of LC3 in articular cartilage decreased. PMID: 25708836
18. Japanese encephalitis virus replication is negatively regulated by autophagy and occurs on LC3-I- and EDEM1-containing membranes PMID: 25046112
19. Deleting Atg7 or Atg5 or blocking LC3 lipidation or ATG5-ATG12 conjugation decreases ERK phosphorylation. PMID: 24240988
20. FYVE and coiled-coil domain containing 1 (FYCO1), a protein previously implicated in autophagosome trafficking, is recruited directly by LC3 to Dectin-1 phagosomes. PMID: 24442442
21. The LC3-associated phagocytosis (LAP) pathway, which is distinct from macroautophagy, targets L. monocytogenes during the early stage of infection within host macrophages. PMID: 23584039
22. PRIP is a novel LC3-binding protein that acts as a negative modulator of autophagosome formation. PMID: 23399561
23. DNA-immune complexes recruit TLR9 and autophagy protein LC3 to phagosomes through Fc-gamma receptor signaling. LC3-associated phagocytosis (LAP), which is distinct from conventional autophagy, is required for IFN-alpha secretion but not for TLR9-mediated TNF secretion. LAP mediates trafficking of TLR9 into a specialized IFN-signaling compartment that initiates IFN-alpha production. PMID: 23219390
24. The effect of chronic infection with Heligmosomoides polygyrus on autophagy is associated with decreased expression and processing of LC3, a key component of the autophagic machinery. PMID: 22732589
25. The LC3 participates in polarized secretion of lysosomal contents into the extracellular space by directing lysosomes to fuse with the plasma membrane. PMID: 22055344
26. Autophagy machinery is recruited to pathogen-containing phagosomes, termed LC3-associated phagocytosis (LAP), which results in degradation of phagocytosed cargo. LAP occurs upon uptake of apoptotic, necrotic, and RIPK3-dependent necrotic cells. PMID: 21969579
27. Data show that luminal P-PERK and LC3 levels are reduced in PERK-deficient mammary glands, whereas they are increased in human breast ductal carcinoma in situ. PMID: 21709020
28. inhibition of proteasomal degradation results in increased oligomerization and activation of caspase-8 on intracellular membranes; enhanced caspase-8 oligomerization and activation are promoted through interaction with SQSTM1/p62 and (LC3) PMID: 21628531
29. Mycobacterium marinum lacking the region of difference 1 (RD1) is unable to recruit LC3, indicating that a functional ESX-1 secretion system is an absolute requirement for this process. PMID: 21447143
30. BopA and bipD mutants both showed a higher level of co-localization with LC3 and the lysosomal marker LAMP1. PMID: 21412437
31. MURF2 expression parallels that of the autophagy-associated proteins LC3, p62/SQSTM1 and nbr1 PMID: 21185285
32. p62 localizes to the endoplasmic reticulum (ER)-associated autophagosome formation site independently of LC3 localization to membranes. PMID: 21220506
33. This study identifies the host cellular pathway hijacked for supplying coronavirus replication membranes and describes an autophagy-independent role for nonlipidated LC3-I. PMID: 20542253
34. Data report embryonic expression patterns for LC3alpha and LC3beta, with some overlap but notable differences in the brain, and in tissues of non-neuronal origin. PMID: 18069693
35. these results indicate that the LC3 conjugation system is critically involved in lipid metabolism via lipid droplet formation. PMID: 19285958
36. LC3 was colocalized with the H2-DM-positive lysosomal compartments in both cortical and medullary thymic epithelial cell lines PMID: 19915056

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KEGG: mmu:66734

STRING: 10090.ENSMUSP00000029128

UniGene: Mm.196239