Recombinant Mouse Mitogen-activated protein kinase 7 (Mapk7), partial

1. These findings highlight the importance of the Mek5-Erk5-Smurf-Smad-Sox9 axis in mammalian skeletogenesis. PMID: 29986870
2. ERK5 provides a common bypass route in intestinal epithelial cells, which rescues cell proliferation upon abrogation of ERK1/2 signalling, with therapeutic implications in colorectal cancer. PMID: 27187615
3. the data revealed that puerarin inhibited the monocyte adhesion in vitro and in vivo and thus reduced atherosclerotic lesions in apoE-/- mice; the protective effects were mediated by activation of ERK5/KLF2 signaling pathway. PMID: 29723698
4. Extracellular-signal-regulated kinase 5 plays an essential role in the gestational augmentation of beta-cell proliferation. PMID: 29159830
5. This study was undertaken to explore the mechanism whereby ERK5 inhibition instigates pancreatic beta-cell apoptosis via an endoplasmic reticulum stress-dependent signaling pathway. PMID: 28681594
6. the present study demonstrated that ERK5 positively regulates TS-induced urocystic EMT in vivo. These findings indicate the important role of ERK5 in TS-associated carcinogenesis and provide a potential strategy for the search of a novel interventional target in TS-associated bladder tumorigenesis. PMID: 28440402
7. These findings define an antagonistic function of ATM and MAPK7 in the thymocyte response to DNA damage, and suggest that the lack of MAPK7 inhibits thymic lymphoma growth in Atm-/- mice by partially restoring the DNA damage response in thymocytes. PMID: 27793024
8. Erk5 role in the cardiac mitochondria and the Pgc-1alpha regulation PMID: 28887535
9. FOXF1 promotes prostate tumor growth and progression by activating ERK5 signaling PMID: 27165781
10. Erk5 MAP kinase is activated in response to PDGF-BB in the smooth muscle cell line MOVAS in a manner dependent on Mekk2, Mek1/2, Mek5, PI3-kinase and protein kinase C (PKC). PMID: 27339033
11. Using compound selectivity engineering and CRISPR/Cas9 genome editing, distinct functions for Erk5 and Brd4 in pluripotency regulation of mouse embryonic stem cells have been revealed. PMID: 27498864
12. our results offer a preclinical proof of concept for ERK5 as a target to enhance T-cell infiltrates in prostate cancer PMID: 28515147
13. This study indicated that MAN can protect osteoblast against oxidative damage by modulation of ERK5/Nrf2 signaling, which can be new agent for osteoporosis. PMID: 28669729
14. These findings suggest that atherogenic conditions critically regulate platelet CD36 signaling by increasing superoxide radical anion and hydrogen peroxide through a mechanism that promotes activation of MAPK ERK5. PMID: 28336528
15. Fluid shear stress acts on the Galphaq-ERK5 signaling pathway to upregulate Cyclin B1 and CDK1 expression, thereby resulting in MC3T3-E1 cell proliferation. PMID: 27115838
16. Finally, we demonstrated that miR-24 plays the modulational role by directly repressing MAPK7, a key number in the MAPK signaling pathway. These data indicate that miR-24 is a novel positive regulator of adipocyte differentiation by targeting MAPK7, which provides new insights into the molecular mechanism of miRNA-mediated cellular differentiation. PMID: 27103442
17. Data, including data from studies in knockout mice, suggest that Erk5/Mapk7 is required for tobacco smoke-triggered gastric epithelial-mesenchymal transition; can be suppressed by dietary factors (here, supplementation with epigallocatechin-3-gallate); suppression of Erk5/Mapk7 activation reverses tobacco smoke-triggered epithelial-mesenchymal transition in gastric mucosa. PMID: 27447666
18. ERK5 activation is essential for osteoclast differentiation. PMID: 25885811
19. Extracellular signal-regulated kinase 5 promotes acute cellular and systemic inflammation. PMID: 26307013
20. ERK5 negatively regulates cigarette smoke-mediated pulmonary epithelial mesenchymal transformation. PMID: 25965818
21. Our findings define ERK5 as a novel kinase that modulates the levels of TCR/CD3 at the cell surface by promoting CD3zeta degradation and TCR/CD3 recovery after TCR stimulation. PMID: 26302753
22. The ERK5 pathway is essential in the induction of COX-2 gene. PMID: 25976667
23. This study reveals a novel role for the ERK5-MEF2 cascade, linking bFGF-induced PAI-1 expression and subsequent mitogenic processes in lung fibroblasts. PMID: 26032256
24. Data suggest that co-administration of FTI-277 and GGTI-298 provided an alternative pharmacological strategy for activating ERK5 that may be effective as a therapeutic tool for the treatment of vascular diseases but devoid of myotoxicity. PMID: 25829196
25. ERK5 functions as a platelet activator in ischemic conditions, and platelet ERK5 triggers myocardial infarct expansion. PMID: 25934838
26. ERK5 activation enhances adult neurogenesis in the olfactory bulb and improves short-term olfactory memory and odor-cued associative olfactory learning. PMID: 25995470
27. Considering that ERK5 is expressed in almost all tumor types, our findings suggest that targeting tumor-associated inflammation via anti-ERK5 therapy may have broad implications for the treatment of human tumors. PMID: 25649771
28. ERK5/KLF4 cascade is a common signaling pathway shared by at least two important mechanisms by which neurons can be protected from cell death. PMID: 25015774
29. study has identified statins and antimalarial drugs as strong ERK5 activators and shown that ERK5 activation is preventive of endothelial inflammation and dysfunction and acute allograft rejection. PMID: 25187658
30. Data indicate that extracellular signal-regulated kinase 5 (ERK5) and c-Jun N-terminal kinase (JNK) are important in the differentiation of C3H10T1/2 cells into cardiomyocyte-like cells induced by bone morphogenetic protein 9 (BMP9) transfection. PMID: 25108436
31. activation of ERK5 MAPK by model Gq-coupled GPCRs does not depend on receptor internalization, beta-arrestin recruitment or receptor phosphorylation but rather is dependent on Galphaq-signalling. PMID: 24358341
32. Activation of ERK5 upregulates macrophage efferocytosis, suppressing atherosclerotic plaque formation. PMID: 25001623
33. findings indicate that ERK5 plays a critical role in TGF-beta1-induced pulmonary fibrosis via enhancing Smad3 acetylation. PMID: 24095924
34. expression of ERK5 during development is critical for pheromone response and associated animal behavior in adult mice PMID: 24130808
35. these results demonstrate integration of ERK5 with NFATc4 nucleo-cytoplasmic shuttling and PKA activation in adipocyte signaling. PMID: 24425864
36. ERK5 regulates multiple aspects of adult olfactory bulb neurogenesis. PMID: 23630619
37. ERK5 MAP kinase is a critical kinase signaling pathway regulating adult neurogenesis in the subventricular zone /olfactory bulb PMID: 23185386
38. EGF-responsive ERK5 is expressed in developing fetal mouse submandibular glands, suggesting that both ERK1/2 and ERK5 signaling cascades might play an important role in the regulation of branching morphogenesis. PMID: 23078124
39. The maintenance of established remote contextual fear memory requires ERK5 MAP kinase and ongoing adult neurogenesis in the hippocampus. PMID: 23189204
40. ERK5 is a novel and critical signaling mechanism underlying prolactin-induced adult neurogenesis PMID: 23223235
41. Our study highlights the importance of the p90RSK/ERK5 module as a critical mediator of endothelial dysfunction in diabetes mellitus and atherosclerosis formation. PMID: 23243209
42. Laminar flow induces Nrf2 activation dependent on ERK5 activation, leading to up-regulation of Nrf2. PMID: 23043106
43. Data suggest ERK5 signaling as a critical regulator of adult hippocampal neurogenesis. PMID: 22645146
44. we demonstrate that ERK5/AP-1/cyclin D1 pathway is involved in the mechanism of osteoblasts proliferation induced by cyclic fluid shear stress, which is superior in promoting cellular proliferation compared with continuous fluid shear stress. PMID: 22286747
45. the mechanisms of mechanosensation by highlighting the link between ERK5 activation and cytoskeletal reorganization in osteoblasts undergoing fluid shear stress PMID: 21954859
46. the regulation of neuronal morphogenesis is proposed as the first physiological function of the ERK3/MK5 signaling module PMID: 22508986
47. ERK5 MAP kinase displays a novel signaling pathway regulating adult neurogenesis in the dentate gyrus and demonstrates a causal relationship between ERK5-regulated adult neurogenesis and the expression of remote memory. PMID: 22573667
48. BMK1 signaling suppresses epithelial-mesenchymal transition. BMK1 elevation augmented E-cadherin-mediated cell-cell adhesion, downregulated mesenchymal markers, and decreased cell motility. PMID: 22282661
49. ERK5 is a novel signaling pathway regulating developmental OB neurogenesis and olfactory behavior. PMID: 22442076
50. PKCzeta is essential for Gq-dependent ERK5 activation in cardiomyocytes and cardiac fibroblasts and indicate a key cardiac physiological role for the Galpha(q)/PKCzeta/ERK5 signaling axis. PMID: 22232556

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KEGG: mmu:23939

STRING: 10090.ENSMUSP00000078087

UniGene: Mm.38172