Recombinant Mouse Muscular LMNA-interacting protein (Mlip)

Code CSB-YP705057MO
MSDS
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Source Yeast
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Code CSB-EP705057MO
MSDS
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Source E.coli
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Code CSB-EP705057MO-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP705057MO
MSDS
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Source Baculovirus
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Code CSB-MP705057MO
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
Mlip
Uniprot No.
Alternative Names
Mlip; CipMuscular LMNA-interacting protein; Cardiac Isl1-interacting protein; CIP; Muscular-enriched A-type laminin-interacting protein
Species
Mus musculus (Mouse)
Expression Region
1-269
Target Protein Sequence
MEFGKHEPGS SLKRNKNLEE GVTFEYSDHM TFSSESKQER VQRILDYPSE VSGRNSQQKE FNTKEPQGMQ KGDLFKAEYV FIVDSDGEDE ATCRQGEQGP PGGPGNIATR PKSLAISSSL ASDVVRPKVR GADLKTSSHP EIPHGIAPQQ KHGLALDEPA RTESNSKASV LDLPVEHSSD SPSRPPQTML GSETIKTPTT HPRAAGRETK YANLSSSSST ASESQLTKPG VIRPVPVKSK LLLRKDEEVY EPNPFSKYLE DNSGLFSEQ
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Required for precocious cardiac adaptation to stress through integrated regulation of the AKT/mTOR pathways and FOXO1. Regulates cardiac homeostasis and plays an important role in protection against cardiac hypertrophy. Acts as a transcriptional cofactor, represses transactivator activity of ISL1 and MYOCD.
Gene References into Functions
  1. Deletion of the CIP-encoding gene accelerated progress from hypertrophy to heart failure in several cardiomyopathy models. PMID: 26436652
  2. Mlip-deficient hearts showed an impaired capacity to adapt to stress (isoproterenol-induced hypertrophy), likely because of deregulated Akt/mTOR activity. PMID: 26359501
  3. studies identify cardiac Isl1-interacting protein (CIP) as a novel regulator of cardiac hypertrophy. PMID: 22343712
  4. MLIP is expressed most highly in striated and smooth muscle, it is likely to contribute to the mesenchymal phenotypes of laminopathies. PMID: 21498514
Subcellular Location
Nucleus. Nucleus envelope. Nucleus, PML body. Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side.
Tissue Specificity
Ubiquitous but more abundantly expressed in heart, skeletal and smooth muscle (at protein level). In brain, expressed by a subpopulation of cells within the hippocampus and cortex. In heart, expressed by ventricular cardiomyocytes. Expression is highly re
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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