Recombinant Mouse Neurofilament medium polypeptide (Nefm), partial

1. Gene deletion studies demonstrated for the first time that lack of NFM leads to changes of D1R-mediated long-term potentiation and D1R-mediated behavior PMID: 25869803
2. Data conclude that NF-H and NF-M C-terminal domains do not normally regulate NF transport rates as previously proposed, but instead increase the proteolytic resistance of NF, thereby stabilizing the stationary neurofilament cytoskeleton along axons. PMID: 23028520
3. Computational modeling predicted that an expanded NF-M C terminus extended farther from the neurofilament core independent of lysine-serine-proline (KSP) phosphorylation. PMID: 22553027
4. results obtained in mouse model for leprous neuropathy indicate biochemical alterations in neurofilaments, i.e., hyperphosphorylation of NF-H and NF-M PMID: 20306637
5. Data show that the tail domain of neurofilament subunit NF-M, with seven KSP motifs, is an essential target for the myelination-dependent outside-in signaling cascade that determines axonal caliber and conduction velocity of motor axons. PMID: 14662745
6. results demonstrate NF-M tail-mediated interactions of neurofilaments, independent of NF transport rate, are critical determinants of the size and cytoskeletal architecture of axons and are mediated in part by the highly phosphorylated tail domain of NF-M PMID: 14662746
7. NF-M regulates the association of NFs with kinesin. PMID: 16246456
8. Alpha-internexin coassembles with all 3 neurofilament proteins into a single network of filaments in quadruple-transfected cells. Deleting NF-M alone or together with NF-H in mice reduces alpha-internexin transport & content in axons throughout the CNS. PMID: 17005864
9. data indicate that a blockade of NMDA receptors during development of cortical neurons increases the phosphorylation state and the solubility of NF-M, thereby favoring neurite outgrowth PMID: 18412220
10. Phosphorylation of NF-M lysine-serine-proline (KSP) repeats is not an essential component for the acquisition of normal axonal caliber mediated by myelin-dependent outside-in signaling. PMID: 19193875
11. RE1 silencing transcription factor (REST) plays a contributory role in the neuron-specific expression of the alpha-internexin, NF-H and NF-M genes PMID: 19457133

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KEGG: mmu:18040

STRING: 10090.ENSMUSP00000022638

UniGene: Mm.242832