Recombinant Mouse Nuclear factor 1 A-type (Nfia)

1. Of these, NFIA emerged as the regulator yielding the strongest molecular and cellular phenotypes. To examine its regulatory function, we profiled the genomic localization of NFIA, identifying it as a key early regulator of terminal brown fat cell differentiation. PMID: 28181539
2. The NFIA identifies a subset of bipolar cells as well as Muller glia and astrocytes. During early postnatal development, NFIA labels astrocytes on the day of birth, AII amacrine cells at postnatal (P) day 5, and Muller glia by P10, when horizontal cells also transiently exhibit NFIA immunofluorescence. PMID: 29071714
3. NFIA expression regulates glioma tumorigenesis and glia-specific enhancers enhancers contribute to glioma formation. PMID: 28892058
4. NFIA activates the cell-type-specific enhancers and facilitates the binding of PPARgamma to control the brown fat gene program. PMID: 28812581
5. Dihydrocapsaicin can significantly decrease proinflammatory cytokines through enhancing NFIA and inhibiting NF-kappaB expression PMID: 27267730
6. Astrocyte induction by Zbtb20 is suppressed by knockdown of NFIA. PMID: 27000654
7. NFI-A disrupts myeloid cell differentiation and maturation in septic mice PMID: 26259914
8. NFIA and NFIB are endogenously expressed in gradients with high caudo-medial to low rostro-lateral expression ... this expression pattern deviates from that of PAX6, suggesting that PAX6 does not drive Nfi expression PMID: 26021864
9. RP5-833A20.1/miR-382-5p/NFIA pathway was essential to the regulation of cholesterol homeostasis and inflammatory reactions. PMID: 25265644
10. Nfia cooperates with sonic hedgehog signaling to initiate medulloblastoma. PMID: 24167280
11. Our data thus suggest that NFI nucleosomal interaction may contribute to the partitioning of distinct chromatin domains and to epigenetic gene expression regulation PMID: 23402308
12. As maturing cerebellar granule neurons become more hyperpolarized, NFATc4 binding declines leading to onset of NFI temporal binding and the NFI switch program PMID: 23407945
13. NFIA and NFIB are expressed in both the developing and the adult olfactory bulb indicative of a regulatory role for these transcription factors in the development of this facet of the olfactory system. PMID: 22886731
14. NFIA is expressed in oligodendrocyte progenitors, but not differentiated oligodendrocytes during mouse embryonic development. PMID: 22807310
15. NFIA is a transcription factor that plays a crucial role in the onset of gliogenesis; we found that its induction is regulated by the transcription factor Sox9 and that this relationship mediates the initiation of gliogenesis PMID: 22500632
16. The studies demonstrate for the first time a requirement for the NFI-A transcription factor in antigen receptor-induced T-cell activation events. PMID: 21602176
17. Nfia plays a central role in nervous system development, driving the expression of astrocyte-specific genes but also suppressing the progenitor cell state to allow differentiation to occur. PMID: 20610746
18. findings suggest that NFI-A, in particular its brain-specific isoform, represses cell adhesion molecule L1 gene expression. PMID: 20003413
19. Abnormal development of forebrain midline glia and commissural projections in Nfia knock-out mice. PMID: 12514217
20. nuclear factor I has a role in the intrinsic control of cerebellar granule neuron gene expression PMID: 15466411
21. brain development, especially oligodendrocyte maturation, is delayed in Nfia-/- mice during the early postnatal period, which at least partly accounts for their phenotype PMID: 17475010
22. The mouse Nfia mutant phenotype and the common features among five human cases indicate that NFIA haploinsufficiency contributes to a novel human central nervous system malformation syndrome that can also include ureteral and renal defects. PMID: 17530927
23. new molecular mechanisms controlling osteoclast differentiation and function by the miRNA system and specifically by miRNA-223, which regulates NFI-A and the M-CSFR levels. PMID: 19059913

Show More

Hide All

KEGG: mmu:18027

STRING: 10090.ENSMUSP00000074899

UniGene: Mm.31274