Recombinant Mouse Nuclear factor NF-kappa-B p100 subunit (Nfkb2), partial

1. in vivo bioluminescence imaging in a transgenic model of inflammation showed that luciferase activity coincided with endogenous p52/p100 Nfkb2 expression PMID: 29680659
2. our studies for the first time establish p100 as a key tumor suppressor of bladder cancer growth PMID: 27095572
3. hyperresponsive promoter engaged the RelA:p52 dimer generated during costimulation of macrophages through TLR4 and LTbetaR to trigger synthesis of IkappaBalpha at late time points, which prevented the late-acting RelA cross-talk response. PMID: 27923915
4. results suggest that changes in the relative concentrations of RelB, NIK:IKK1, and p100 during noncanonical signaling modulate this transitional complex and are critical for maintaining the fine balance between the processing and protection of p100. PMID: 27678221
5. Results suggest that the RelB/NF-kappaB2 pathway regulates T cell migration to autoimmune targets in Sjogren syndrome through TGFbeta/TGFbetaR-dependent regulation of CXCL12/CXCR4 signaling. PMID: 28804991
6. MKK4 activates non-canonical NFkappaB signaling by promoting NFkappaB2-p100 processing. PMID: 28733031
7. the aberrant proliferative capacity of Brca1(-/-) luminal progenitor cells is linked to the replication-associated DNA damage response, where proliferation of mammary progenitors is perpetuated by damage-induced, autologous NF-kappaB signaling. PMID: 27292187
8. RelB is processed by CO2 in a manner dependent on a key C-terminal domain located in its transactivation domain. Loss of the RelB transactivation domain alters NF-kappaB-dependent transcriptional activity, and loss of p100 alters sensitivity of RelB to CO2 PMID: 28507099
9. we identify in this study a critical role for the combined activity of the RELB and NF-kappaB2 subunits in B cell homeostasis that cannot be compensated for by the canonical NF-kappaB pathway under physiological conditions. PMID: 26851215
10. Mechanistically the LncRNA-HIT siRNA treatments impacted pro-chondrogenic gene expression by reducing H3K27ac or p100 activity, confirming that LncRNA-HIT is essential for chondrogenic differentiation in the limb mesenchyme PMID: 26633036
11. Nfkb2 connected lymphotoxin signal within the intestinal niche in reinforcing epithelial innate inflammatory RelA/NF-kappaB response to Citrobacter rodentium infection, while Nfkb2(-/-) mice succumbed to gut infections owing to stromal defects. PMID: 25905673
12. Data indicate a coupled increase in the expression of renal, relA, NF-kB2, and p53 genes and proteins during folic acid induced acute kidney injury (AKI). PMID: 25559736
13. Loss of c-REL but not NF-kappaB2 prevents autoimmune disease driven by FasL mutation. PMID: 25361085
14. NF-kappaB2/p52 is necessary for the development of colitis, whilst c-Rel-mediated signalling regulates colonic epithelial cell turnover following DNA damage. PMID: 25727407
15. Nuclear translocation of c-Rel was enhanced in p100-deficient cells. p100, and not the processed p52 form, associated with c-Rel in the steady state and dissociated immediately after lipopolysaccharide stimulation in wild-type dendritic cells PMID: 25305492
16. The unique ability of p100/IkappaBdelta to stably interact with all NF-kappaB subunits by forming kappaBsomes demonstrates its importance in sequestering NF-kappaB subunits and releasing them as dictated by specific stimuli for developmental programs. PMID: 25349408
17. that p52 binds to the promoter of the GM-CSF-encoding gene (Csf2) and cooperates with c-Rel in the transactivation of this target gene. PMID: 24899500
18. NF-kappaB p65/p52 signaling mediated the effects of GDNF on Bcl-2 and Bcl-w expressions PMID: 23590664
19. Heterozygous mutations in NFKB2 cause a unique form of early-onset CVID that also presents with central adrenal insufficiency. PMID: 24140114
20. p100 deficiency alone was insufficient for full induction of genes regulated by the alternative NF-kappaB pathway. PMID: 22880094
21. RelB/NF-kappaB2 signaling positively and intrinsically regulates hematopoietic stem/progenitor cell self-renewal. PMID: 22290873
22. the alternative the NF-kappaB pathway via the processing of p52 from p100 negatively regulates osteoblastic differentiation and bone formation by modifying bone morphogenetic protein activity. PMID: 22282470
23. The p52/RelB noncanonical pathway is critical to sustain CXCL12/SDF1 production in order for cells to migrate toward chromatin architectural protein HMGB1. PMID: 22287708
24. Nuclear factor-kappaB2/p100 promotes endometrial carcinoma cell survival under hypoxia in a HIF-1alpha independent manner. PMID: 21537326
25. findings demonstrate the physiological relevance of the NF-kappaB2 p100 precursor protein in limiting the potentially detrimental effects of constitutive NF-kappaB2 signaling in lymphocytes PMID: 20363924
26. Mice that were deficient in the alternative NF-kappaB pathway subunit p52 showed an impaired T-cell response against lymphocytic choriomeningitis virus infection. PMID: 20565293
27. Results show that TNF limits RANKL- and TNF-induced osteoclast formation in vitro and in vivo by increasing NF-kappaB p100 protein accumulation in osteoclast precursors. PMID: 19770515
28. Nfkb2 knockout mice develop chronic trichuriasis associated with elevated production of antigen-specific IFN-gamma but can recover IL-13 responses and resistance to infection if IL-12 responses are blocked. PMID: 12370384
29. ligation of CD40 on transfected 293 cells is shown to trigger p52 production by stimulating p100 ubiquitylation and subsequent proteasome-mediated proteolysis PMID: 12374738
30. mice injected with BAFF-neutralizing BR3-Fc protein showed reduced basal NF-kappaB2 activation PMID: 12387744
31. NF-kappa B2 p100 has I kappa B-independent apoptotic activity and a unique tumour suppressor role PMID: 12389034
32. role in Peyer's patch development along with RelB and p50, focusing on lymphotoxin and tumor necrosis factor signal transduction PMID: 12505990
33. RelB has an effect on p100 processing, which is possibly regulated in a signal-dependent manner PMID: 12874295
34. controls osteoclatogenesis PMID: 12939342
35. NF-kappaB2 represses RelB in dendritic cells (DC) by a regulatory pathway that may function to prevent DC hyperactivation, with critical consequences for the regulation of adaptive immune responses. PMID: 14707043
36. Results identify a novel type of NF-kappaB-binding site in IkappaB kinase alpha-dependent chemokine gene promoters that is preferentially recognized by RelB:p52 dimers. PMID: 15470505
37. IkappaB kinase alpha has an essential role in the constitutive processing of NF-kappaB2 p100 PMID: 15677466
38. RelB/p52 complexes have roles in mammary gland development and carcinogenesis PMID: 16260626
39. CD14-mediated LPS signaling pathway may play a role in the regulation of NF-kappaB alternative splicing in the lungs after injury PMID: 16480837
40. Akt plays a role in activation of basal and induced non-canonical NF-kappaB activity PMID: 16613850
41. NF-kappaB2 (p100) limits nuclear translocation of NF-kappaB1-RelA and thereby functions as a regulatory 'brake' for the activation of naive T cells. PMID: 16732290
42. NF-kappaB2 downstream of lymphotoxin beta receptor plays an important role in the regulation of central tolerance in an autoimmune regulator-dependent manner PMID: 17039258
43. findings identify a physiological function of NF-kappaB2 in the development of medullary thymic epithelial cells and, thus, the control of self-tolerance induction PMID: 17046818
44. Our genetic evidence confirms that p100 is required and sufficient as a fourth IkappaB protein for noncanonical NF-kappaB signaling downstream of NIK and IKK1 PMID: 17254973
45. Increased p100/p52 disrupts normal mammary gland ductal development by a mechanism which may contribute to human breast cancer. PMID: 17261585
46. activation of NF-kappaB2/p100 plays a crucial role in the Tax1-mediated transformation of T cells PMID: 17715223
47. production of NF-kappaB2 p52 is not tumorigenic but predisposes mice to inflammatory autoimmune disease by repressing Bim expression PMID: 18281283
48. inhibition of TRAF3 results in coordinated activation of both the p50-dependent and p52-dependent NF-kappaB activation pathways PMID: 18292232
49. tightly controlled p100 processing and RelB activation is essential for normal B lymphopoiesis and lymphoid/myeloid lineage decision in bone marrow PMID: 18505785
50. RIG-1 - MAVS interacts with cytoplasmic 100-kDa NF-kappa B2 complexes via a novel retinoic acid-inducible gene-I - NF- kappa B-inducing kinase signaling pathway PMID: 18550535

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KEGG: mmu:18034

STRING: 10090.ENSMUSP00000072859

UniGene: Mm.102365