Recombinant Mouse Oligodendrocyte transcription factor 2 (Olig2)

1. Cuprizone-induced schizophrenia-like symptoms involved olig2 upregulation. The silence of olig2 could prevent changes, likely through regulating MBP, CNPase, and GFAP expressions. PMID: 28989170
2. transient hypoxia at P7 altered the expression of Olig1 and Nkx2.2, resulting in delayed myelination in the external capsule. PMID: 28546087
3. Functionally, deletion of Olig2 alone results in a preferential reduction of Purkinje cells in the cerebellum, which is likely mediated by decreased neuronal generation from their cerebellar ventricular zone progenitors. PMID: 27469598
4. Olig2 is down-regulated in oligodendrocyte progenitor cells infected by Theiler's murine encephalomyelitis virus. PMID: 26631080
5. phosphorylation of the motif itself serves as a template to prime phosphorylation of additional serines and creates a highly charged "acid blob" in the amino terminus of Olig2. PMID: 28355568
6. OLIG2 modulates growth factor signaling in two distinct populations of glioma stem cells, characterized by expression of either the epidermal growth factor receptor (EGFR) or platelet-derived growth factor receptor alpha. PMID: 27626655
7. the dynamic interplay between HMGNs and H1 in chromatin epigenetically regulates the expression of OLIG1&2, thereby affecting oligodendrocyte development and myelination, and mouse behavior. PMID: 27923998
8. Olig2 was significantly upregulated and transcriptionally targeted the Gpr17 locus PMID: 27733608
9. Brg1 represses Olig2 expression and the specification of oligodendrocyte progenitors, but is required for OPC differentiation and oligodendrocyte maturation PMID: 27067865
10. Data show that oligodendrocyte transcription factor 2 (Olig2) deletion causes platelet-derived growth factor receptor (PDGFR) downregulation and reciprocal epidermal growth factor receptor (EGFR) upregulation. PMID: 27165742
11. This study suggests that Olig2 misexpression in neural stem cells elicits neurogenesis defects and neuronal cell death, which may contribute to developmental disorders including Down syndrome PMID: 25747816
12. OLIG2 is a multifunctional regulator of neural stem cell self-renewal PMID: 25294244
13. Olig2 expression is localized to the cochleovestibular ganglia from E12.5 through E14.5 PMID: 25778822
14. Olig2 overexpression accelerates the differentiation of mouse embryonic stem cells into oligodendrocyte progenitor cells in vitro. PMID: 25200136
15. This study demonstrated that that OLIG2 overexpression in oligodendrocyte progenitor cells might be a possible therapeutic mechanism for enhancing myelin repair. PMID: 25564492
16. Results from expression pattern suggests that Olig2 may have an important role in the early stage of Purkinje cell development. PMID: 24594479
17. Prox1 controls binary fate decisions between motor neurons and V2 interneurons in progenitor cells via direct repression of Olig2 gene regulatory elements PMID: 25411508
18. Phosphorylated Olig2 is preferentially localized to a transcriptionally active compartment for regulation of gene expression. PMID: 24948806
19. Olig2 is involved in correct formation of the prethalamus. PMID: 24803655
20. Notch signaling might promote proliferation and differentiation of reactive astrocytes through regulation of nucleo-cytoplasmic translocation of Olig2. PMID: 23396245
21. Olig2/Plp-positive progenitor cells give rise to Bergmann glia in the cerebellum. PMID: 23492777
22. The results of this study suggested a stage-specific regulatory role for Olig2, mediated by Olig1 that conveys opposing functions on the differentiation and maturation of oligodendrocytes. PMID: 23658182
23. This study demonistrated that in chronic demyelinated lesions more Olig2-lineage cells are produced as part of the repair process, but their processes degenerate after maturation. PMID: 23172790
24. Olig2 protein has the ability to permeate the cell membrane without the addition of a protein transduction domain (PTD), similar to other basic helix-loop-helix transcription factors such as MyoD and NeuroD2. PMID: 23022191
25. Study finds that the oligodendrocyte-lineage determination factor Olig2 transcriptionally prepatterns the chromatin-remodeling factor Smarca4/Brg1 to the enhancer elements to control oligodendrocyte differentiation. PMID: 23332759
26. Olig2 is strictly required to maintain the malignancy of oligodendroglioma cells. PMID: 22514120
27. The findings indicated that NG2+ polydendrocytes in the embryonic and early postnatal brain exhibit developmental fate switch from oligodendrocytes to astrocytes in vivo upon removal of Olig2. PMID: 22627280
28. The Olig2 can induce desired neuronal lineages from most expressing neural progenitor cells by a mechanism resembling developmental binary cell-fate switching. PMID: 21624811
29. analysis of conserved and non-conserved functional elements at the Olig1 and Olig2 locus PMID: 21206754
30. Data show that Olig2 affects a key posttranslational modification of p53 in both normal and malignant neural progenitors and thereby antagonizes the interaction of p53 with promoter elements of multiple target genes. PMID: 21397859
31. In the phosphorylated state, Olig2 maintains antineural (i.e., promitotic) functions that are reflected in human glioma cells and in a genetically defined murine model of primary glioma. PMID: 21382551
32. We conclude that S147 phosphorylation of OLIG2, possibly by protein kinase A, is required for motor neuron but not oligodendrocyte precursor genesis and propose that dephosphorylation triggers the switch. PMID: 21382552
33. the percentage of virus-infected cells with Na(+) currents was increased by inhibition of the repressor function of Olig2 and by overexpression of Pax6 PMID: 21051674
34. Olig1 and Olig2, two genes that are triplicated in Down syndrome were overexpressed in a widely used model of Down syndrome PMID: 20639873
35. Olig2 is expressed in the ventral thalamus of developing mice PMID: 11960707
36. Olig2 is an essential transcriptional regulator in motoneuron and oligodendrocyte development PMID: 12121626
37. Both Olig2 and MASH1 are required topromoter Shh-mediated forebrain GABAergic neuronal/oligodendrocyte lineage restrictionand exhibit complementary & cooperative factor interactions. PMID: 12461181
38. the OLIG2 protein in the nuclei of neural precursor cells disappears in accordance with astrocytic differentiation during culture with leukemia inhibitory factor PMID: 14576772
39. Nkx6.1 controls oligodendrocyte development in the developing spinal cord, possibly by regulating Olig gene expression in the ventral neuroepithelium PMID: 14602683
40. Interference with Olig2 in neurospheres revealed its role in self-renewal during expansion and for the generation of neurons and oligodendrocytes during differentiation. PMID: 15080895
41. Olig2+ progenitor cells have features of glial cells but are able to divide rapidly for at least 1 month while still expressing Olig2. The cells differentiate into astrocyte-like and oligodendrocyte-like cells when switched to serum-containing medium. PMID: 15139016
42. AKT-stimulated export of OLIG2 from the nucleus of neural stem cells is essential for astrocyte differentiation. PMID: 15452140
43. Olig2/Ngn2 ratio in motor neuron progenitor cells serves as a gate for timing proper gene expression during the development. PMID: 15655114
44. results indicate that Olig2 serves a critical role in pan-glial versus neuronal fate decisions in subventricular zone (SVZ) progenitors, making it the first intrinsic fate determinant shown to operate in the early postnatal SVZ PMID: 16093378
45. the introduced overexpression of Olig2 could induce the development of fully mature oligodendrocytes expressing the transcription factor Nkx2.2 and all major myelin-specific proteins PMID: 16253982
46. Olig2 is a repressor of neurogenesis in cells reacting to brain injury. PMID: 16330768
47. Olig2(+) progenitors do not maintain neurogenic potential into the period of gliogenesis and therefore do not self-renew PMID: 16432183
48. These results suggest that olig2 is involved in the maintenance of the undifferentiated state of retinal progenitor cells. PMID: 16514356
49. When the Olig2-expressing cells at E12.5 were permanently modified to express the lacZ or EGFP gene, the cells marked by reporter gene expression were widely distributed in the basal forebrain by E18.5, some of which expressed neuronal markers. PMID: 16537079
50. motoneurons and oligodendrocyte progenitors are derived from the Olig2+ progenitors in the restricted domain of the ventral ventricular zone of the embryonic spinal cord PMID: 16581057

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KEGG: mmu:50913

STRING: 10090.ENSMUSP00000036797

UniGene: Mm.37289