Recombinant Mouse Paired box protein Pax-7 (Pax7)

1. It inhibits adipogenesis. PMID: 29900636
2. Transfection experiments showed that the PAX7 splice-site mutation putatively causes nonsense-mediated mRNA decay affecting onlyPAX7 isoform 3. PMID: 28779497
3. The DUX4 homeodomains mediate inhibition of myogenesis and are functionally exchangeable with the Pax7 homeodomain. PMID: 28935672
4. Pax7 activates Zac1 to regulate GPR39 expression in myocytes. PMID: 29079520
5. Barx2 and Pax7 regulate the canonical Wnt target gene Axin2, which mediates critical feedback to terminate the transcriptional response to Wnt signals. PMID: 27144473
6. Stat3 regulates self-renewal of adult muscle satellite cells during injury-induced muscle regeneration through various partners, such as Pax7. PMID: 27524611
7. Lkb1 activates the Notch signaling pathway, which subsequently increases Pax7 expression and promotes self-renewal and proliferation while inhibiting differentiation. Mechanistic studies reveal that Lkb1 regulates Notch activation through AMPK-mTOR pathway in myoblasts. PMID: 27131604
8. Pax7 binding induces dramatic, localized remodeling of chromatin characterized by the acquisition of histone marks associated with enhancer activity and induction of chromatin accessibility in both muscle precursors and lineage-committed myoblasts. Conversely, removal of Pax7 leads to rapid reversal of these features on a subset of enhancers. PMID: 28441415
9. the absence of functional Pax7 in differentiating embryonic stem cells modulates cell cycle facilitating their proliferation. PMID: 27610933
10. findings demonstrate a key role for the lingual epithelial signals in supporting the integrity of the lamina propria and muscular tissue during tongue development and that a Wnt/Notch/Pax7 genetic hierarchy is involved in this development. PMID: 28438836
11. results support the concept that lack of functional Pax7 promotes proliferation of differentiating ESCs and for this reason more of them can turn into myogenic lineage. PMID: 28017376
12. the absence of functional Pax7 does not prevent the in vitro myogenic differentiation of embryonic stem cells. PMID: 26649785
13. These results underscore DNA demethylation as a key mechanism driving myogenesis and identify specific Pax7-mediated DNA demethylation signatures to acquire and maintain the muscle-cell identity. PMID: 27075038
14. miR-431 transgenic mice are a unique genetic model for investigating the cellular features and biological functions of Pax7(Lo) satellite cells during muscle development and regeneration. PMID: 26151913
15. Caspase 3 cleavage of Pax7 has a role in inhibiting self-renewal of satellite cells PMID: 26372956
16. Brg1 functions as a positive regulator for cellular proliferation and survival of primary myoblasts via pax7. PMID: 26036967
17. Loss of Pax7 expression is associated with craniofacial abnormalities. PMID: 25800090
18. Low RAGE activity in embryonal rhabdomyosarcoma cells results in high PAX7 levels that sustain migration and invasiveness. PMID: 25123133
19. PAX7+ subset of A(single) spermatogonia functions as robust testis stem cells that maintain fertility in normal spermatogenesis in healthy mice and mediate recovery after severe germline injury, such as occurs after cancer therapy. PMID: 25133429
20. antagonism between Barx2 and Pax7 in regulation of Wnt signaling may help mediate the switch from myoblast proliferation to differentiation. PMID: 24753152
21. Data conclude that Pax7 acts at different levels in a nonhierarchical regulatory network controlling muscle-satellite-cell-mediated muscle regeneration. PMID: 23933088
22. Pax7 responds to NF-kappaB by impairing the regenerative capacity of myogenic cells in the muscle microenvironment to drive muscle wasting in cancer. PMID: 24084740
23. Pax7 expression is an absolute prerequisite for the normal function of satellite cells during regenerative myogenesis at any age. PMID: 24065826
24. Arginine methylation of Pax7 by Carm1 functions as a molecular switch controlling the epigenetic induction of Myf5 during satellite stem cell asymmetric division and entry into the myogenic program. PMID: 22863532
25. Pax7 lineage contributions to the mammalian neural crest. PMID: 22848431
26. a role of Notch signaling in actively promoting the self-renewal of muscle stem cells through direct regulation of Pax7 PMID: 22493066
27. Pax7 acts by remodeling chromatin and allowing Tpit binding to a new subset of enhancers for activation of melanotrope-specific genes PMID: 23070814
28. The data demonstrated distinct attributes of Pax7 function and provided insight into the nonredundancy of Pax3 and Pax7 in muscle development. Both Pax3 and Pax7 bound identical DNA motifs, with Pax7 having a higher binding affinity. PMID: 22609161
29. Transcript levels of the transcription factor Pax7 that is expressed in muscle progenitors were enhanced by cyclin D3 expression in myoblasts. PMID: 21898542
30. As expected, both adhesive behavior/Pax7(+)/laminin(-) and non-adhesive behavior/Pax7(-)/laminin(+) myogenic cells consistently appeared in the adhesive and non-adhesive behavior cell culture. PMID: 21274567
31. miR-206 and -486 are induced during myoblast differentiation and downregulate Pax7 by directly targeting its 3' untranslated region PMID: 21041476
32. Our results provide the first evidence for a population of Pax7-expressing embryonic progenitors that contribute to multiple olfactory epithelium lineages. PMID: 20631180
33. Here, we define the 5' end of the cDNA for murine Pax7 and identify the transcriptional start site PMID: 14559212
34. Pax7 is necessary and sufficient to induce the myogenic specification of CD45(+)Sca1(+) stem cells resident in adult skeletal muscle PMID: 15138500
35. essential function of Pax7 for renewal and maintenance of muscle stem cells PMID: 15282552
36. Data show that Pax7 is able to drive transcription in quiescent and activated satellite cells, and continues to do so in those cells that subsequently cease proliferation and withdraw from immediate differentiation. PMID: 16608873
37. These results implicate Pax7 as an important determinant of polarity within the mouse superior colliculus, and suggest a role in retinotopic mapping. PMID: 17091300
38. A cross-inhibitory interaction between Pax7 and members of the muscle regulatory factor family modulates cell fate decisions resulting in proliferation, differentiation, and self-renewal, necessary for skeletal muscle maintenance and repair. PMID: 17548510
39. increased expression of Pax7 promotes satellite cell self-renewal. PMID: 17949710
40. Data show Pax7 induces chromatin modifications that stimulate transcriptional activation of target genes to regulate entry into the myogenic developmental programme. PMID: 18066051
41. Direct functional role played by Pax7 during embryonic development. PMID: 18198279
42. during superior collicular development, Pax7 is required to maintain a subpopulation of dorsal, mesencephalic neurons and partially regulates, spatiotemporally, Pax3 expression within the CNS PMID: 18513381
43. Pax7-expressing cells (satellite cells) in the limb, head, and diaphragm muscles are homogeneous in size and granularity and uniformly labeled by certain cell surface markers, including CD34 and CD29 PMID: 18802040
44. DUX4 expression interferes with Pax7 in satellite cells, and inappropriately regulates Pax targets, including myogenic regulatory factors, during regeneration PMID: 18833193
45. Pax7-dependent myogenic progenitor cells are of prime importance for striated muscle formation PMID: 19301402
46. Id3 is a direct transcriptional target for Pax7 in quiescent satellite cells. PMID: 19458195
47. Pax7 directly targets and regulates specific myogenic and neurogenic genes. PMID: 18198279

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KEGG: mmu:18509

STRING: 10090.ENSMUSP00000030508

UniGene: Mm.218760