Recombinant Mouse Patatin-like phospholipase domain-containing protein 2 (Pnpla2), partial

1. ATGL in brown adipose tissue is not a prerequisite for cold-induced thermogenesis in vivo. PMID: 28988821
2. Non-cardiac ATGL-mediated modulation of the cardiac lipidome may play an important role in the pathogenesis of chronic heart failure. PMID: 29320510
3. this study shows that long non-coding steroid receptor RNA activator promotes hepatic steatosis through repressing the expression of ATGL PMID: 27759039
4. ATGL deficiency results in male infertility in mice. PMID: 28510703
5. Loss of ATGL induces spontaneous development of pulmonary neoplasia in knockout mouse model. PMID: 27213586
6. ATGL acts as an important upstream signaling node that, via SIRT1, increases autophagy/lipophagy as a means to promote hepatic lipid droplet catabolism. PMID: 28380348
7. CGI-58 regulates hepatic neutral lipid storage and inflammation in the genetic absence of ATGL. PMID: 27396333
8. Enhanced lipolysis in response to mitochondrial uncoupling relies on a form of autophagy as lipid droplets are captured by endolysosomal vesicles which is HSL/ATGL-independent. PMID: 28488768
9. The Atgl is down-regulated by the basal transcription factor Sp1 in preadipocytes and that the magnitude of down-regulation depends on interactions between Sp1 and peroxisome proliferator-activated receptor gamma (PPARgamma). PMID: 28726642
10. TAG synthesis and levels of PUFA-TAGs were lowered by the diacylglycerol acyltransferase (DGAT)1 inhibitor, T863. The lipase inhibitor, Atglistatin, increased the levels of TAG in both WT and ATGL-deficient mouse Hepatic stellate cell (HSC). Both Atglistatin and T863 inhibited the induction of activation marker, alpha-smooth muscle actin, in rat HSCs, but not in mouse HSCs. PMID: 27179362
11. G0S2 protein but not mRNA levels were reduced in the adipose tissue of ATGL-deficient mice, corroborating the involvement of ATGL in the stabilization of G0S2 PMID: 27248498
12. Atgl deficiency induces podocyte apoptosis and leads to glomerular filtration barrier damage. PMID: 28194887
13. These data raise the possibility that ATGL deficiency could impair the renal fatty acid metabolism though inhibiting PPARalphaexpression, which may lead to lipid deposition and cell apoptosis of PCT, and finally contribute to the renal fibrosis and dysfunction PMID: 28400046
14. Markers of mitochondrial content and respiration were increased in adipose tissue from ATGL knockout mice. PMID: 27357546
15. ase. Similar changes of GPNMB and G0S2 expression were present in a human liposarcoma database. These results show that a previously-unknown, fully penetrant epistatic interaction between Pnpla2 and Lipe can cause liposarcoma in mice. DAKO mice provide a promising model for studying early premalignant changes that lead to late-onset malignant disease. PMID: 28459858
16. ANGPTL8 is a stress-response protein that down-regulates expression of ATGL. PMID: 26569053
17. ATGL KO mice had significantly lower fasting plasma free fatty-acids compared to WT. Fasting endogenous glucose production and peripheral glucose metabolism were similar in KO and WT mice. PMID: 26236747
18. Pharmacological inhibition of ATGL may prove useful to prevent HFD-induced obesity and insulin resistance PMID: 26508640
19. A role for Atgl in kidney lipolysis:fasting up-regulates Atgl levels and phosphorylation in mouse kidney. PMID: 25879679
20. data provide mechanistic insights into Jordans' anomaly in neutrophils and suggest that ATGL is a potent regulator of immune cell function and inflammatory diseases. PMID: 26109679
21. Data show that obese adipocyte-specific adipose triglyceride lipase (ATGL) knockout (AAKO) mice had reduced adipocyte lipolysis. PMID: 26196542
22. transcriptional transactivation assays with a luciferase reporter system revealed that Fabps enhance the ability of Atgl/Cgi-58-mediated lipolysis to induce the activity of peroxisome proliferator-activated receptors. PMID: 25953897
23. Data (including data from studies in atherosclerotic knockout mice) suggest CGI58- (abhydrolase domain containing 5-)deficient macrophages store-up triglyceride droplets and have reduced phagocytic capacity, comparable to Atgl-deficient macrophages. PMID: 25316883
24. Data suggest that cardiotrophin-1 up-regulates lipolysis in white adipocytes via 1) induction of perilipin, 2) activation of hormone sensitive lipase (via phosphorylation by PKA), and 3) inactivation of ATGL (via up-regulation of its inhibitor G0S2). PMID: 25351614
25. 4E-BP1/2-null cells express less ATGL and accumulate more fat than control cells, while knock down of Egr1 in 4E-BP1/2-null cells increases ATGL expression and decreases fat storage. PMID: 25814662
26. ATGL acts as retinyl ester hydrolase in hepatic stellate cells promoting the degradation of retinyl ester stores in addition to its established function as Triglyceride lipase. PMID: 25732851
27. ATGL overexpression in C2C12 myotubes increased lipolysis, which was associated with increased peroxisome proliferator-activated receptor (PPAR)- partial differential activity, transcriptional upregulation of some PPAR partial differential target genes, and enhanced mitochondrial capacity. PMID: 25852007
28. Adipocyte rather than skeletal myocyte ATGL-mediated lipolysis plays a greater role during acute exercise in part because of compensatory mechanisms that maintain lipolysis in muscle, but not adipose tissue, when ATGL is absent. PMID: 25783895
29. The anti-lipolytic activity of the HCV core protein alters ATGL binding to CGI-58 and enhances the association of both proteins with lipid droplets. PMID: 25381252
30. L-FABP is not required to channel ATGL-hydrolyzed FAs to mitochondria for beta-oxidation or the nucleus for PPAR-alpha regulation PMID: 24610891
31. ESR1 regulates ATGL and perilipin-mediated lipid metabolism and droplet size in femurs from mice. PMID: 23296636
32. Data (including data from studies using site-directed mutagenesis of ATGL/PNPLA2) suggest threonine-372 is phosphorylation site that plays critical role in regulating subcellular distribution and lipolytic activity of ATGL/PNPLA2 in white adipocytes. PMID: 24801391
33. ATGL promotes the expression of genes related to mitochondrial oxidative metabolism (activate the PPARa-PGC-1a complex). PMID: 24096872
34. Desnutrin-catalyzed lipolysis activates PPAR delta, rather than PPAR alpha, which in turn is critical for expression of genes involved in mitochondrial function, and thus ATP production, required for glucose-stimulated insulin secretion. PMID: 24268737
35. Systemic knockout of adipose triglyceride lipase (ATGL), the pivotal enzyme of triglyceride lipolysis, results in a murine phenotype that is characterized by progredient cardiac steatosis and severe heart failure PMID: 24657704
36. These findings unravel a novel protective role of ATGL against hepatic inflammation which could have important implications for metabolic and inflammatory liver diseases. PMID: 24002947
37. acquired cardiomyocyte-specific ATGL deficiency is sufficient to promote fibrotic and hypertrophic cardiomyopathy and impair myocardial fatty acid oxidation in the absence of markedly reduced PPARalpha signalling PMID: 23708736
38. It added genetic stress due to knockout (KO) of adipocyte triglyceride lipase (ATGL), the rate limiting enzyme in lipid droplets(LD) lipolysis. PMID: 23740967
39. These results suggest that reduced ATGL and CGI-58 expression and increased TG synthesis may exacerbate myocardial steatosis and oxidative stress, thereby promoting cardiac apoptosis in diabetic mice. PMID: 23886955
40. chronic reduction in myocardial TAG content by cardiomyocyte specific ATGL overexpression is able to prevent doxorubicin induced cardiac dysfunction. PMID: 23704323
41. data suggest that ATGL(-/-)mSMC have a distinct phenotype that may be related to vascular pathogenesis PMID: 23583398
42. Data suggest that increased expression of Atgl in myocardium is adaptive response to accumulation of myocardial triglycerides in diabetes; study included mice with either heterozygous ATGL deficiency or cardiomyocyte-specific ATGL overexpression. PMID: 23349479
43. the role of ATGL in modulating PPARalpha-dependent processes also in the small intestine PMID: 23220585
44. FSP27 acts to constitutively limit the lipid droplet presence of ATGL, perilipin 1 plays an essential role in mediating the response of ATGL action to beta-adrenergic hormones. PMID: 23204327
45. functional muscle lipolysis depends on both CGI-58 and ATGL PMID: 23413028
46. data suggest that hepatic ATGL knockdown enhances glucose tolerance by increasing hepatic glucose utilization and uncouples impairments in insulin action from hepatic TAG accumulation PMID: 22993196
47. analysis ofsubstrate and stereo/regioselectivity of adipose triglyceride lipase, hormone-sensitive lipase, and diacylglycerol-O-acyltransferases PMID: 23066022
48. Studies suggest that beta-adrenergic activation can result in PKA-mediated phosphorylation of ATGL Ser(406), to moderately increase ATGL-mediated lipolysis. PMID: 22733971
49. investigation of role of Atgl in skeletal muscle of Atgl knockout (KO) mice: Mitochondrial oxidative phosphorylation is unaltered in Atgl KO mice. Electrostimulation yields reduced force production/higher relaxation in Atgl KO mice. PMID: 22496349
50. genetic control of ATGL-mediated lipolysis modulates adipose triglyceride level and resistance to obesity and diabetes PMID: 22383686

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KEGG: mmu:66853

STRING: 10090.ENSMUSP00000127149

UniGene: Mm.29998