Recombinant Mouse Phospholipid hydroperoxide glutathione peroxidase, mitochondrial (Gpx4), partial

1. paternal acetylated histones and acrosomal nuclear GPx4 are directly involved in fertilization. PMID: 28802016
2. Gpx4 was dispensable for the maintenance of cellular health and function of POMC neurons, even in mice exposed to obesogenic conditions. In contrast, HFHS-fed mice with Gpx4 deletion from AgRP neurons displayed increased body adiposity. Gpx4 deletion from dopaminergic neurons induced anxiety behavior, and diminished spontaneous locomotor activity when DJ-1 was co-deleted. PMID: 28627418
3. After tamoxifen treatment to ablate Gpx4, Gpx4BIKO mice developed impairment in hippocampus dependent spatial learning and memory function which was associated with neurodegeneration. Consistent with its role as a regulator of ferroptosis, cognitive impairment and neurodegeneration in Gpx4BIKO mice was associated with elevated lipid peroxidation, ERK(1/2) activation and overt neuroinflammation. PMID: 28212525
4. The structure of the cytoplasmic isoform of mouse phospholipid hydroperoxide glutathione peroxidase (O70325-2 GPx4) with selenocysteine 46 mutated to cysteine is reported. PMID: 27710939
5. ferroptosis regulator Gpx4 is critical for hepatocyte survival and proper liver function, and that vitamin E can compensate for its loss by protecting cells against deleterious lipid peroxidation. PMID: 27262435
6. These data suggest that systemic inactivation of the Alox15 gene normalizes the reduced fertility of male Sec46Ala-Gpx4(+/-) mice by improving the motility of their sperm. If these data can be confirmed in humans, ALOX15 inhibitors might counteract male infertility related to GPX4 deficiency. PMID: 27634046
7. Phospholipid hydroperoxide glutathione peroxidase is involved in the maintenance of male fertility under cryptorchidism in mice PMID: 26050606
8. dramatic motor neuron degeneration and paralysis induced by Gpx4 ablation suggest that ferroptosis inhibition by GPX4 is essential for motor neuron health and survival in vivo PMID: 26400084
9. The lack of catalytic activity is the major reason for the embryonic lethality of Gpx4 knockout mice. PMID: 25313597
10. Homozygous expression of Gpx4 with a targeted substitution of selenocysteine to serine causes early embryonic death as expected but, unexpectedly, male subfertility in heterozygous mice. PMID: 25922076
11. GPx4 suppresses the increase in the VEGF-A protein level, which occurs during the development of pathological CNV, thus partly explaining the protective effect of GPx4 against CNV. PMID: 24897344
12. Inducible disruption of Gpx4 causes acute renal failure and early death in an Alox15-independent manner PMID: 25402683
13. A membrane glycoprotein GPX4 was shown to play a significant role in gamete interactions. PMID: 24191733
14. Rat Gpx4 is a moonlighting protein that functions both as a peroxidase, as well as a structural protein. PMID: 10464096
15. GPx4-overexpressing mice showed no free fatty acid induced increase in reactive oxygen species and lipid peroxidation PMID: 23695217
16. Activity of cutaneous GPx4 is linked to the regulation of COX-2 and hair follicle morphogenesis and provides insight into the function of individual selenoprotein activity in maintaining cutaneous homeostasis. PMID: 23364477
17. enzymatic epididymal salvage response is sufficient to maintain full fertility of double GPx4 and GPx5 KO males whatever their age, crossed with young WT female mice PMID: 22719900
18. Tam treatment also significantly elevated apoptosis in Gpx4(f/f)/Cre mice. Moreover, tam-treated Gpx4(f/f)/Cre mice showed neuronal loss in the hippocampus region and had increased astrogliosis PMID: 22401858
19. GPx4 is a critical antioxidant enzyme for the maturation and survival of photoreceptor cells. PMID: 22207760
20. the absence of nuclear GPx4 leads to sperm nuclear matrix/chromatin instability that may negatively affect embryo development PMID: 21618532
21. Phospholipid hydroperoxide glutathione peroxidase gene is regulated via an estrogen and estrogen receptor signaling in cultured mouse fetuses PMID: 21717270
22. Data indicate that both catalytic efficiency and the expression level of GPx4 control the balance between cell survival and proliferation. PMID: 21402720
23. Absence of glutathione peroxidase 4 affects tumor angiogenesis through increased 12/15-lipoxygenase activity. PMID: 20234819
24. Data conclude that GPx4 is a selenoenzyme modulating interneuron function and parvalbumin expression. PMID: 19890015
25. These data suggest a role of GPx4 in neurodegenerative diseases through its function in removal of lipid hydroperoxides. PMID: 19769463
26. in three models of oxidative damage-induced retinal degeneration, increased expression of Gpx4 provided strong protection of retinal structure and function PMID: 18823256
27. analysis of mRNA in testis and other tissues PMID: 12152197
28. tissue distribution of alternatively spliced snGPx PMID: 12427732
29. observations establish glutathione peroxidase 4 as an essential antioxidant enzyme in mice and suggest that it performs broad functions as a component of the mammalian antioxidant network PMID: 12566075
30. Early embryonic lethality caused by targeted disruption of the PHGPx gene. PMID: 12745070
31. Functional characterization of cis- and trans-regulatory elements involved in expression of phospholipid hydroperoxide glutathione peroxidase. PMID: 12888488
32. mouse embryonic fibroblasts from Gpx4(+/-) mice are more sensitive to oxidative stress PMID: 14572612
33. Gpx4 plays a role in vivo in the mechanism of apoptosis induced by oxidative stress that most likely occurs through oxidative damage to mitochondrial phospholipids such as cardiolipin PMID: 15496407
34. TGR and GPx4 can serve as a novel disulfide bond formation system and contain a catalytic selenocysteine consistent with the role of selenium in male reproduction PMID: 15901730
35. nPHGPx, by acting as a protein thiol peroxidase in vivo, contributes to the structural stability of sperm chromatin PMID: 16107710
36. Gpx4 haploid insufficiency reduced Gpx4 activities and/or selenium concentrations, but had no effect on pro-oxidant-induced protein oxidation in various tissues. PMID: 16246897
37. phospholipid hydroperoxide glutathione peroxidase isoforms have roles in murine embryogenesis PMID: 16684775
38. Therefore, our results indicate that decreased ATP production under oxidative stress is primarily due to reduced mitochondrial membrane potential and overexpression of Gpx4 maintains mitochondrial membrane potential under oxidative stress. PMID: 17395155
39. These results indicate that PHGPx exhibits a cell- and tissue-specific expression pattern in mice. PMID: 17503194
40. Mitochondrial PHGPx expression is tightly regulated in pachytene spermatocytes, with any increase in PHGPx expression resulting in damage to spermatogenesis and eventual loss of haploid cells PMID: 17540721
41. lifelong reduction in Gpx4 increased life span and reduced/retarded age-related pathology most likely through alterations in sensitivity of tissues to apoptosis PMID: 17895430
42. adult lung fibroblasts deficient in GPx4 may have upregulated compensatory mechanisms to deal with the highly oxidized environment in which they developed. PMID: 18206984
43. Neuron-specific GPx4 depletion caused neurodegeneration in vivo and ex vivo, highlighting the importance of this pathway in neuronal cells. PMID: 18762024
44. mitochondrial GPx4 confers the vital role of selenium in mammalian male fertility PMID: 19417079
45. Transgenic mouse models for the vital selenoenzymes cytosolic thioredoxin reductase, mitochondrial thioredoxin reductase and glutathione peroxidase 4. PMID: 19433132
46. Liver apoptosis and Cyt c release are suppressed in Tg(GPX4+/0) mice but exacerbated in Gpx4+/- mice PMID: 19447173
47. depletion of GPx4 in spermatocytes causes severe abnormalities in spermatozoa PMID: 19783653

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KEGG: mmu:625249

UniGene: Mm.332810