Recombinant Mouse Proline-serine-threonine phosphatase-interacting protein 2 (Pstpip2)

Code CSB-YP859980MO
MSDS
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Source Yeast
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Code CSB-EP859980MO
MSDS
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Source E.coli
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Code CSB-EP859980MO-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP859980MO
MSDS
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Source Baculovirus
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Code CSB-MP859980MO
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
Pstpip2
Uniprot No.
Alternative Names
Pstpip2; Mayp; Proline-serine-threonine phosphatase-interacting protein 2; PEST phosphatase-interacting protein 2; Macrophage actin-associated tyrosine-phosphorylated protein; pp37
Species
Mus musculus (Mouse)
Expression Region
2-334
Target Protein Sequence
TGSLFKGNF WSTDILSTIG YDSIIQHLNN GRKNCKEFED FLKERASIEE KYGKDLLNLS RKKPCGQSEI NTLKRALEVF KQQVDNVAQC HIQLAQTLRE EARKMEEFRE KQKLQRKKTE TIMDAAHKQR NAQFKKAMDA KKNYEQKCRD KDEAEQAVHR SANVANQRQQ EKLFVKLATS KTAVEDSDKA YMLHINMLEK VREDWQSEHI KACEVFEAQE CERINFFRNA LWLHLNQLSQ QCVANDEMYE QVRKSLETCS IEKDIQYFVN QRKTGQTPPA PIMYENFYSP QRNAAPPGKT TGPNPARRGP LPVPKRIPDD PDYSVVEDYS LLYQ
Protein Length
Full Length of Mature Protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Binds to F-actin. May be involved in regulation of the actin cytoskeleton.
Gene References into Functions
  1. PSTPIP2 could play a role in innate immunity and development of autoinflammatory bone disorders, and may be associated with the pathogenesis of SAPHO syndrome. PMID: 25602062
  2. Knockdown of PSTPIP2 inmacrophages enhances the assembly of FBP17, leading to'hyperactivation' of actin nucleation at podosomes and ECM degradation. PMID: 23525018
  3. PSTPIP2 deficiency in mice causes osteopenia and increased differentiation of multipotent myeloid precursors into osteoclasts. PMID: 22923495
  4. our pstpip2 mutant mice provide a new model for investigating the potential mechanisms of inflammatory pain. PMID: 22646813
  5. MAYP directly regulates F-actin bundling and enhances filopodia formation and motility in macrophages. PMID: 15788569
  6. A missense mutation in pstpip2 is associated with the autoinflammatory disorder chronic multifocal osteomyelitis. PMID: 16122996
  7. mutations are associated with spontaneous disease in mouse model of osteomyelitis PMID: 18721907
  8. PSTPIP2 deficiency leads to autoinflammatory disease. PMID: 19608749

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Subcellular Location
Cytoplasm. Membrane; Peripheral membrane protein.
Tissue Specificity
Expressed in macrophage-containing tissues, including bone marrow, spleen, liver, kidney, intestine and brain.
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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