Recombinant Mouse Protein Wnt-11(Wnt11)

Code CSB-YP026131MO
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Source Yeast
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Code CSB-EP026131MO
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Source E.coli
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Code CSB-EP026131MO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP026131MO
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Source Baculovirus
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Code CSB-MP026131MO
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Wnt11
Uniprot No. P48615
Alternative Names Wnt11; Wnt-11; Protein Wnt-11
Species Mus musculus (Mouse)
Expression Region 25-354
Target Protein Sequence IKWLAL SKTPAALALN QTQHCKQLEG LVSAQVQLCR SNLELMRTIV HAARGAMKAC RRAFADMRWN CSSIELAPNY LLDLERGTRE SAFVYALSAA TISHTIARAC TSGDLPGCSC GPVPGEPPGP GNRWGGCADN LSYGLLMGAK FSDAPMKVKK TGSQANKLMR LHNSEVGRQA LRASLETKCK CHGVSGSCSI RTCWKGLQEL QDVAADLKTR YLSATKVVHR PMGTRKHLVP KDLDIRPVKD SELVYLQSSP DFCMKNEKVG SHGTQDRQCN KTSNGSDSCD LMCCGRGYNP YTDRVVERCH CKYHWCCYVT CRRCERTVER YVCK
Protein Length Full Length of Mature Protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.
Gene References into Functions
  1. These studies revealed a previously unappreciated role for WNT11 for dorsal mesenchymal protrusion (DMP) formation and distinct tissue-specific requirements for WNT11 in outflow tract and DMP development. PMID: 28669819
  2. Wnt4 and Wnt11 cooperatively contribute to mammalian neuromuscular junction formation. PMID: 28348167
  3. Results provide evidence that Wnt11 is involved in the organization of kidney tubules through the planar cell polarity pathway taking part in fine-tuning of nephrogenesis. PMID: 27582005
  4. under tensile stress, miR-154-5p negatively regulates ADSCs osteogenic differentiation through the Wnt/PCP pathway by directly targeting Wnt11 PMID: 25959411
  5. a mechanistic link between E-cadherin loss and subsequent control of Rho-driven anoikis resistance through p120- and Kaiso-dependent expression of Wnt11, is reported. PMID: 25713299
  6. Studied groups of embryoid bodies (EBs) with different starting numbers of ESCs & found differential gene expression patterns for Wnt5a & Wnt11. Wnt11 inc'd the percentage of beating EBs by upregulating expression of cardiac-specific genes. PMID: 25312921
  7. Data show that Wnt5a and Wnt11 are required for proper patterning of the neural tube and somites by regulating notochord formation. PMID: 25813538
  8. These results provide formal genetic proof that the majority of the endocardium and myocardium diverge by mid-gastrulation in the mouse, and suggest a tight spatial and temporal control of Wnt11 expression in the myocardial lineage. PMID: 25448697
  9. Wnt5a/Wnt11 inhibit beta-catenin to promote SHF development through Caspase-dependent Akt degradation PMID: 25482987
  10. The apical and basolateral secretion of Wnt11 and Wnt3a in polarized epithelial cells is regulated by different mechanisms. PMID: 23613470
  11. demonstrates that the combination of Wnt11 and BMP-2 effectively promotes cardiomyogenic differentiation of BM-MSCs in vitro. The synergistic effect of Wnt11 and BMP-2 on the cardiomyogenic differentiation of BM-MSCs is further enhanced in myocardium PMID: 22829700
  12. all the TGF-beta, Wnt11, and JNK targets were activated in a unilateral ureteral obstruction (UUO) model of renal fibrosis in vivo. PMID: 22556418
  13. Transplantation of MSC(Wnt11) improved cardiac function. The release of Wnt11 and other factors from transplanted MSC(Wnt11) is more likely responsible for protection of native CM at risk. PMID: 21463175
  14. Wnt11 is involved in the protection of the host intestinal cells by blocking the invasion of pathogenic bacteria, suppressing inflammation, and inhibiting apoptosis. PMID: 21903761
  15. noncanonical Wnt (Wnt11) enhanced cardiomyocyte differentiation while preventing stabilization of the beta-catenin protein, suggesting active repression of canonical Wnt signals PMID: 21041481
  16. GLI3 repressor controls nephron number by regulating ureteric tip cell expression of Wnt11 and Ret PMID: 19809516
  17. Wnt-11 signalling serves as a critical cell adhesion cue for the organization of the cardiomyocytes in the developing ventricular wall, which is essential for the establishment of a functional heart. PMID: 19622544
  18. Data show that the higher expression of WNT5a in smaller EBs enhanced endothelial cell differentiation, and in contrast, the increased expression of WNT11 enhanced cardiogenesis. PMID: 19805103
  19. Wnt11 and Ret/Gdnf cooperate in coordinating ureteric branching by maintaining a balance of Wnt11-expressing ureteric epithelium and Gdnf-expressing mesenchyme in developing kidney PMID: 12783789
  20. Wnt11-mediated suppression of canonical signaling exists in vivo PMID: 15067007
  21. epithelial Wnt11, mesenchymal Gdnf and stromal Fgf7 signalling is coordinated by sprouty proteins during kidney development, which regulates ureteric branching PMID: 15201220
  22. We propose that Wnt11 plays an important role for cardiac development by embryoid bodies, and may be a key regulator of cardiac muscle cell proliferation and differentiation during heart development. PMID: 15541384
  23. Expression levels of the beta-catenin-independent Wnts, Wnt-4, -5a and -11 were up-regulated transiently during cutaneous wound healing. PMID: 16426441
  24. Within fetal liver kinase (Flk)1-positive cells, Wnt11 may play a critical role in Flk1-positive cell fate determination, at least partially by modulating canonical Wnt/beta-catenin signalling. PMID: 17154359
  25. initiation of metanephric kidney development requires the reduction of BMP4 activity by the antagonist gremlin 1 in the mesenchyme, which in turn enables ureteric bud outgrowth and establishment of autoregulatory GDNF/WNT11 feedback signalling PMID: 17522159
  26. We have found that Wnt11 is a direct target of a canonical beta-catenin pathway in developing heart and that Wnt11 mutants show cardiac outflow tract defects.Wnt signaling requires ATF/CREB for signalling. PMID: 17767158
  27. Negative feedback of fibroblast factors triggers excessive cell proliferation then inhibits the expression of Fgfr1b and activates the expression of Wnt11 to fuse each palate. PMID: 18191119
  28. AT1R-mediated inhibition of the Spry1 gene increases c-Ret tyrosine kinase activity leading to upregulation of its downstream target Wnt11, which induces GDNF in adjacent mesenchyme causing focal bursts of ureteric bud tip cell proliferation PMID: 18650792
  29. Wnt11 signals through beta-catenin, activating Rspo2 expression, which is then required for Wnt11-mediated osteoblast maturation. PMID: 19213727

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Subcellular Location Secreted, extracellular space, extracellular matrix.
Protein Families Wnt family
Database Links

KEGG: mmu:22411

STRING: 10090.ENSMUSP00000064333

UniGene: Mm.22182

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