Recombinant Mouse Protein lin-28 homolog A (Lin28a)

1. LIN28A inhibits lysosomeassociated membrane glycoprotein 1 protein expression in embryonic stem and bladder cancer cells. PMID: 29749495
2. Overexpression of Lin28a, an RNA-binding protein that regulates organismal growth and metabolism, in articular chondrocyte progenitor cells upregulated Erk signaling and increased articular cartilage thickness. PMID: 30042178
3. The apoptotic protection by Lin28a inhibition is likely through the activation of TrkA signaling pathway. PMID: 29245067
4. In the absence of Eprn, Lin28a expression is reduced which results in persistence of let-7 microRNAs, and the up-regulation of de novo methyltransferases Dnmt3a/b is delayed. Dnmt3a/b deletion retards ES cell transition, correlating with delayed Nanog promoter methylation and phenocopying loss of Eprn or Lin28a. PMID: 28820723
5. miR-145 modulation of Sox2-Lin28/let-7 network is crucial for neurogenesis progression. PMID: 26849971
6. the specific interaction between zinc knuckle domain of LIN28 and pre-let-7 is necessary and sufficient to induce oligouridylation. PMID: 28297670
7. The results reveal a key role of Wnt-Lin28-let7 miRNA signaling in regulating proliferation and neurogenic potential of Muller glial cells in the adult mammalian retina. PMID: 27681429
8. LIN28 specifically marks undifferentiated spermatogonia in mice. The LIN28-expressing undifferentiated spermatogonia exist as two subpopulations: Ngn3-GFP-negative (high stem cell potential) and Ngn3-GFP-positive (high differentiation commitment) PMID: 19563657
9. Overexpression of LIN28A, which is a hallmark of human ETMRs, augments Sonic-hedgehog (Shh) and Wnt signaling in embryonal tumors with multilayered rosettes precursor cells through the downregulation of let7-miRNA, and LIN28A/let7a interaction with the Shh pathway was detected at the level of Gli mRNA. PMID: 28892064
10. During ESC differentiation, Lin28 transient induction is dependent on Otx2 and Hmga2 and prevents an inappropriate excessive rise of Hmga2 levels.- PMID: 27920151
11. LIN28A and LIN28B play cooperative roles in regulating reprogramming, naive/primed pluripotency, and stem cell metabolism. PMID: 27320042
12. MAPK/ERK directly impacts LIN28, defining an axis that connects signalling, post-transcriptional gene control, and cell fate regulation. PMID: 27992407
13. Sirt1 knockdown abolished the protective effects of Lin28a against cardiac remodeling and dysfunction after MI, and Lin28a failed to increase the numbers of GFP-LC3-positive punctae and decrease aggresome and p62 accumulation in Sirt1-knockdown neonatal cardiomyocytes subjected to hypoxia-induced injury. PMID: 27693787
14. data point toward a complex system of regulation by Lin28a, Lin28b, and let-7, in which Lin28b and let-7 can impact both puberty and growth in a sex-specific manner PMID: 26698568
15. Lin28A binds active promoters and recruits Tet1 to regulate gene expression via epigenetic DNA modifications. PMID: 26711009
16. Lin28a protects against DCM through PKA/ROCK2 dependent pathway. PMID: 26626075
17. Lin28B upregulation in a mouse model does not affect neuroblast proliferation, ganglion size, and Let-7 expression during early postnatal development PMID: 26674877
18. Data show that the RNA-binding protein lin28a/microRNA let-7a axis regulated glucose metabolism in part through the insulin-PI3K-mTOR pathway. PMID: 25688987
19. Lin28a protects against hypoxia/reoxygenation induced cardiomyocytes apoptosis by alleviating mitochondrial dysfunction under high glucose/high fat conditions PMID: 25313561
20. Lin28a overexpression efficiently and specifically reduces let-7 miRNAs and up-regulates let-7 target genes. PMID: 23940373
21. Lin28 binds to guanine-rich miRNAs and mRNAs that contain G-quartet structural features and remodels these structures. PMID: 26045559
22. Lin28a and Lin28b have overlapping functions in temporally regulating neural progenitor cell proliferation during early brain development. PMID: 25922525
23. LIN28 accelerates tumor formation and enhances proliferation and invasiveness. PMID: 25956904
24. Down-regulation let-7 by transforming growth factor-beta1-induced Lin28 upregulates collagen expression in glomerular mesangial cells from diabetic mice. PMID: 25354942
25. LIN28A marks the spermatogonial progenitor population and regulates its cyclic expansion. PMID: 24715688
26. Our data imply dual repression of Let-7 during oocyte-embryo transition in the mouse model, the selective suppression of Let-7 biogenesis by Lin28 homologs superimposed on previously reported global suppression of miRNA activity. PMID: 24829024
27. Proper regulation of Lin28 and P-TEFb is required to shield ESCs from premature differentiation so that sufficient numbers of cell division can be achieved prior to differentiation to maintain proper organismal sizes. PMID: 24768001
28. Lin28a regulates neuronal differentiation and controls miR-9 production. PMID: 24722317
29. identification of three U-specificity zones that explain how Dis3l2 recognizes, binds and processes uridylated pre-let-7 in the final step of the Lin28-let-7 pathway PMID: 25119025
30. Data implicate fetal expression of Lin28a/b in the regulation of life-long effects on metabolism and growth. PMID: 23666760
31. observed Wilms tumor only when Lin28 is aberrantly expressed in multiple derivatives of the intermediate mesoderm, implicating the cell of origin as a multipotential renal progenitor PMID: 24732380
32. Data suggest that LIN28A plays functional role in regulating trophoblast differentiation/placentation; loss of LIN28A in human trophoblasts is sufficient to induce differentiation, but loss of Lin28a does not induce mouse trophoblast differentiation. PMID: 24006280
33. Lin28a enhances tissue repair in some adult tissues by reprogramming cellular bioenergetics. PMID: 24209617
34. downregulation of let-7 and miR-200 levels initiates and maintains oncostatin M-induced epithelial-to-mesenchymal transition phenotypes, and HMGA2 acts as a master switch of oncostatin M-induced epithelial-to-mesenchymal transition. PMID: 23318420
35. Findings demonstrate a novel role for Lin28 in prostate cancer development and activation of the androgen receptor axis. PMID: 23790802
36. Lin28b and Lin28a expression significantly decrease in C57BL/6 mice prior to puberty. PMID: 23138112
37. divergent patterns of cellular distribution and mRNA expression of Lin28 and Lin28b in the testis during postnatal maturation and their alteration in a model of congenital hypogonadotropic hypogonadism PMID: 23337528
38. Aire promotes the self-renewal of embryonic stem cells through the activation of Lin28 and the inhibition of the let-7 microRNA family. PMID: 22540148
39. LIN28 is an essential factor of nucleologenesis during early embryonic development. PMID: 23172912
40. LIN28A recognizes AAGNNG, AAGNG, and less frequently UGUG, which are located in the terminal loop of a small hairpin. LIN28A is localized to the periendoplasmic reticulum (ER) area and inhibits translation of mRNAs that are destined for the ER, reducing the synthesis of transmembrane proteins, ER or Golgi lumen proteins, and secretory proteins. PMID: 23102813
41. miR-125b/Lin28 axis is an important regulator of early lineage specification and cardiomyocyte differentiation of ESCs. PMID: 22277001
42. LIN28A specifically marks undifferentiated spermatogonia in mice PMID: 19563657
43. The miR-125b target Lin28A is an important regulator of hematopoiesis and a primary target of miR-125b in the hematopoietic system. PMID: 22366319
44. Study reports crystal structures of mouse Lin28 in complex with sequences from let-7d, let-7-f1, and let-7g precursors; two folded domains of Lin28 recognize two distinct regions of the RNA and are sufficient for inhibition of let-7 in vivo. PMID: 22078496
45. When overexpressed in mice, both Lin28a and LIN28B promotes resistance to high-fat-diet induced diabetes; conversely, muscle-specific loss of Lin28a or overexpression of let-7 results in insulin resistance and impaired glucose tolerance. PMID: 21962509
46. Musashi1 cooperates in abnormal cell lineage protein 28 (Lin28)-mediated let-7 family microRNA biogenesis in early neural differentiation. PMID: 21378162
47. miRNAs let-7, mir-125, mir-9, and mir-30 directly repress LIN28 expression in embryonic stem and cancer cells PMID: 20947512
48. Data provide model of human phenotypes associated with genetic variation in the Lin28-Let-7 pathway. PMID: 20512147
49. The role of LIN28 in cell fate succession in vertebrate cells is analogous to its activity as a developmental timing regulator in C. elegans. PMID: 20179095
50. microRNA regulation is a conserved feature of the Lin-28 gene in diverse animals. PMID: 12798299

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KEGG: mmu:83557

STRING: 10090.ENSMUSP00000050488

UniGene: Mm.302567