Recombinant Mouse RAD50-interacting protein 1 (Rint1)

Code CSB-YP804889MO
MSDS
Size Pls inquire
Source Yeast
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Code CSB-EP804889MO
MSDS
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Source E.coli
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Code CSB-EP804889MO-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP804889MO
MSDS
Size Pls inquire
Source Baculovirus
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Code CSB-MP804889MO
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
Rint1
Uniprot No.
Alternative Names
Rint1; RAD50-interacting protein 1; RAD50 interactor 1; RINT-1
Species
Mus musculus (Mouse)
Expression Region
1-792
Target Protein Sequence
MLAADDIGEV PAAPCCPESG DETKNTDVKS DVNTAAPAGS EQLSQGGSDD ALLSYVSAFI EKEVGSDLKS LKTLGKLIEQ MTESKVKLEE QVLTISSEIP KRIQSALKDA EESKQLLDEF LEQEAPLFSS ISSHLLMAQP WMDDLGAMIT QMEEIERHLA YLKWVSQTEE LSDNIQQYLM TNSVPEAASL LVTMTELDIQ LQESSCTHLL SFMRATVKFW HKILKDKLTS DFEEVLAQLH WPFTSHTQSQ TVGGSRPAGT PELYSSLDTL FCQLLKLQAS DELLTEPKQL PEKYCLPASP PVTLPIQVML APLQKRFRYH FRGSRQTNVM SKPEWYLAQV LMWIGNHTQF LDEKIQPILD KVGSAVNARL EFSRGLVMLI LEKLASDIPC LLYDDSLFCH LVDEVLLFER ELHTVHGYPS TFASCMHILS EETCFQRWLT VERKFALQKM DSMLSSEAAW VSQYKDISDV DEMKVPDCAE VFMTLLLVIT DRYKNLPTAS RKLQFLELQK DLVDDFRIRL TQVMKEETRA ALGFRYCAIL NAVNYISAVL ADWADNVFFL QLQQAALEVF AENNVLSKLQ LGQLASMESS VFDDMINLLE RLKLDMLTRQ VDHVFREVKD SAKLYKKERW LSLPSQSEQA VMSLSSSACP LLLTLRDRLL QLEQQLCFSL FRIFWQMLAE KLDLYIYQEI ILANHFNEGG AAQLQFDMTR NLFPLFSHYC KRPENYFKHV KEACIILNLN IGSALLLKDV LQSVSEHIPA TAALNEVGVY KLAQQDVEIL LNLRTNWPNT GK
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum; the function is proposed to depend on its association in the NRZ complex which is believed to play a role in SNARE assembly at the ER. May play a role in cell cycle checkpoint control. Essential for telomere length control.
Gene References into Functions
  1. RINT1 has a role as a multitasking protein with roles in genomic stability, ER homeostasis, and autophagy PMID: 27367497
  2. these data are more consistent with the hypothesis that RINT1 functions as an oncogene rather than a tumor suppressor gene in the context of colorectal cancer. PMID: 28264000
  3. A crucial role of Rint1 in vivo in genomic stability maintenance, as well as in prevention of endoplasmic reticulum stress and autophagy. PMID: 26383973
  4. These findings suggest that RINT-1 serves as a novel tumor suppressor essential for maintaining the dynamic integrity of the Golgi apparatus and the centrosome, a prerequisite to their proper coordination during cell division. PMID: 17470549
Subcellular Location
Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein.
Protein Families
RINT1 family
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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